A New Alternative Synthesis of Salicylaldazine via Microwave Irradiation Method

Kassim, Karimah; Hamali, Muhamad Azwan; Yamin, Bohari Mohd.

doi:10.1155/2019/9546373

Cited by 11 publications

(6 citation statements)

References 14 publications

(17 reference statements)

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“…Sub-fraction MF-14 was assessed to a repeated chromatographic analysis by eluting the column with distilled n-hexane and ethyl acetate (100:0 to 13:87), yielding isolated salicylalazine (1.60 g). The structure of salicylalazine was identified by various spectroscopic techniques and compared with recently reported data [ 9 , 19 ].…”

Section: Methodsmentioning

confidence: 99%

In Vivo and In Vitro Biological Evaluation and Molecular Docking Studies of Compounds Isolated from Micromeria biflora (Buch. Ham. ex D.Don) Benth

et al. 2022

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Micromeria biflora, a traditional medicinal plant, is extensively used for treating various painful conditions, such as nose bleeds, wounds, and sinusitis. A phytochemical investigation of the chloroform fraction of Micromeria biflora led to the isolation of salicylalazine. Salicylalazine was assessed in vivo for analgesia, muscle relaxation, sedative, and anti-inflammatory properties, as well as in vitro for COX-1/2 inhibition activities. It was assessed against a hot plate-induced model at different doses. The muscle relaxant potential of salicylalazine was evaluated in traction and inclined screening models, while sedative properties were determined using an open-field model. The anti-inflammatory potential of salicylalazine was assessed in histamine and carrageenan-induced paw edema screening models. Salicylalazine exhibited significant analgesic potential in a dose-dependent manner. In both screening models, an excellent time-dependent muscle-relaxation effect was observed. Salicylalazine demonstrated excellent sedation at high doses. Its anti-inflammatory activity was determined through the initial and late phases of edema. It exhibited anticancer potential against NCI-H226, HepG2, A498, and MDR2780AD cell lines. In vitro, salicylalazine showed preferential COX-2 inhibition (over COX-1) with an SI value of 4.85. It was less effective in the initial phase, while, in the later phase, it demonstrated significant effects at 15 and 20 mg/kg doses compared with the negative control. Salicylalazine did not exhibit cytotoxicity in the MTT assay, preliminarily indicating its safety.

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Section: Methodsmentioning

confidence: 99%

In Vivo and In Vitro Biological Evaluation and Molecular Docking Studies of Compounds Isolated from Micromeria biflora (Buch. Ham. ex D.Don) Benth

et al. 2022

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“…Kassim et al, 27 synthesized two diazine Schiff-base ligands HL a and HL b derived from thiocarbohydrazine and salicylaldehyde derivatives using microwave assisted synthesis approach. The general pathway for the synthesis of the two ligands that they used is shown Figure 1.…”

Section: Schiff Bases With Biological Activitymentioning

confidence: 99%

A review of Titanium, Vanadium and Chromium transition metal Schiff base complexes with biological and catalytic activities

Assey

Mgohamwende

2020

PPIJ

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Schiff bases are compounds obtained from the condensation reaction of a primary amine and aldehyde or ketone. They can be coordinated with metals especially the transition metals to form Schiff base complexes. The objective of this work is to review the synthesis, biological as well as catalytic activities of both Schiff base ligands and their transition metal complexes of titanium, vanadium as well as chromium. The methodology used for looking for the references were through the internet. Biological activities that were considered in this review were mainly those of antibacterial and antifungal. For the antibacterial, both gram positive and gram negative strain were considered. The results obtained from the study indicated that the Schiff base complexes, Schiff bases as well as metal ions for the metals titanium, vanadium and chromium were used by different researchers to investigate antimicrobial activities against bacteria, fungi as well as anti-tumour activity against breast cancer. The antimicrobial literature studies showed that the metal ions were having lower inhibition capacity than the ligands but the complexes showed the highest inhibition capacity against the microbial. The use of Mono-and dioxide-vanadium (V) complexes showed anticancer activity against MCF-7 (breast cancer) cells. The cis-Dioxido vanadium (V) complexes were also investigated for catalytic activity on the oxidation of cyclohexane and gave conversion of 12% and selectivity of up to 85%. The paper is divided into five sections which include introduction, methodology used in looking for references, results and discussion, acknowledgements and references. The results obtained from the review show that the Schiff base complexes were more effective when screened as anti-microbial compounds than their ligands. The complexes also showed effectiveness when screened for their catalytic activity on organic chemistry reactions.

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“…Various literature reports about the synthesis of Schiff bases are available. These reports show that the transition-metal complexes of Cu(II), Co(II), Fe(II), Ni(II), and V(II) were produced from bidentate Schiff bases, which exhibit good antibacterial activity. , The various organic transformations using a microwave-assisted reaction − are reported. In this work, we report a microwave-assisted synthesis of Schiff bases using anacardic acid present in cashew shell extract, which acts as an acid catalyst.…”

Section: Introductionmentioning

confidence: 99%

Microwave-Assisted Rapid and Green Synthesis of Schiff Bases Using Cashew Shell Extract as a Natural Acid Catalyst

et al. 2022

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The Schiff bases were prepared with aromatic aldehyde and aromatic amine using cashew shell extract as a catalyst under microwave irradiation. This reaction is rapid, efficient, and solvent-free and involves the one-pot synthesis of Schiff bases under microwave irradiation. The synthesized Schiff bases were characterized by Fourier transform infrared (FTIR) spectroscopy, 1H nuclear magnetic resonance (NMR) spectroscopy, 13C NMR spectroscopy, and gas chromatography–mass spectrometry (GC–MS). The advantages of the preparation of Schiff bases under microwave irradiation are high yield, shorter reaction time, easy, elimination of side products, and quick product isolation. The synthesized Schiff base derivatives are well known for their biological activity like antibacterial and antifungal activity.

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A New Alternative Synthesis of Salicylaldazine via Microwave Irradiation Method

Cited by 11 publications

References 14 publications

In Vivo and In Vitro Biological Evaluation and Molecular Docking Studies of Compounds Isolated from Micromeria biflora (Buch. Ham. ex D.Don) Benth

In Vivo and In Vitro Biological Evaluation and Molecular Docking Studies of Compounds Isolated from Micromeria biflora (Buch. Ham. ex D.Don) Benth

A review of Titanium, Vanadium and Chromium transition metal Schiff base complexes with biological and catalytic activities

Microwave-Assisted Rapid and Green Synthesis of Schiff Bases Using Cashew Shell Extract as a Natural Acid Catalyst

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