A review of Titanium, Vanadium and Chromium transition metal Schiff base complexes with biological and catalytic activities

Abstract

Schiff bases are compounds obtained from the condensation reaction of a primary amine and aldehyde or ketone. They can be coordinated with metals especially the transition metals to form Schiff base complexes. The objective of this work is to review the synthesis, biological as well as catalytic activities of both Schiff base ligands and their transition metal complexes of titanium, vanadium as well as chromium. The methodology used for looking for the references were through the internet. Biological activities that were considered in this review were mainly those of antibacterial and antifungal. For the antibacterial, both gram positive and gram negative strain were considered. The results obtained from the study indicated that the Schiff base complexes, Schiff bases as well as metal ions for the metals titanium, vanadium and chromium were used by different researchers to investigate antimicrobial activities against bacteria, fungi as well as anti-tumour activity against breast cancer. The antimicrobial literature studies showed that the metal ions were having lower inhibition capacity than the ligands but the complexes showed the highest inhibition capacity against the microbial. The use of Mono-and dioxide-vanadium (V) complexes showed anticancer activity against MCF-7 (breast cancer) cells. The cis-Dioxido vanadium (V) complexes were also investigated for catalytic activity on the oxidation of cyclohexane and gave conversion of 12% and selectivity of up to 85%. The paper is divided into five sections which include introduction, methodology used in looking for references, results and discussion, acknowledgements and references. The results obtained from the review show that the Schiff base complexes were more effective when screened as anti-microbial compounds than their ligands. The complexes also showed effectiveness when screened for their catalytic activity on organic chemistry reactions.

Synthesis and crystal structure of di-μ-methoxo-bis(oxido{N′-[3-(oxidoimino)butan-2-ylidene]benzohydrazonato-κ3 O,N,O′}vanadium(V))

“…Interest in the coordination complexes of vanadium is primarily due to their variety of roles in biological processes such as nitrogen fixation, haloperoxidation, phosphorylation, insulin mimicking, anti-microbial and anti-fungal activities, and for their possible use as efficient catalysts in various organic reactions (Noblı ´a et al, 2004;Plass et al, 2007;Zabin & Abdelbaset, 2016;Tsave et al, 2016;Tanabe & Nishibayashi, 2019;Assey & Mgohamwende, 2020). Oxovanadium(V) (VO 3+ ) and dioxovanadium(V) (VO 2 + ) catalyzed reactions include C-C bond formation, hydrogenation, dehydrogenation, sulfide oxidation, C-C/C-O bond cleavage, alcohol/aldehyde/ketone oxidation, deoxydehydration (Langeslay et al, 2019).…”

Nano-sized warriors: zinc chromium vanadate nanoparticles as a dual solution for eradicating waterborne enterobacteriaceae and fighting cancer

“…Recent studies have indicated that complexes of metals such as chromium, cobalt, copper, vanadium, manganese, and zinc have huge potential as antimicrobial, anticancer, antioxidant, and antidiabetic properties ( Senthil Raja et al, 2012 ; Al-Hazmi et al, 2020 ). In this regard, Vanadium and chromium play crucial roles and are known for their significant bioactivities like antimicrobial, anticancer, and antiviral ( Crans et al, 2018 ; 2019 ; Selman et al, 2018 ; Assey and Mgohamwende, 2020 ; Suma et al, 2020 ). Vanadium can exist in many oxidation states; therefore, vanadium complexes are attractive to researchers for their promising biological activities.…”

“…Vanadium can exist in many oxidation states; therefore, vanadium complexes are attractive to researchers for their promising biological activities. Several reports are on synthesizing vanadium complexes with different ligands to determine their magnetic, antidiabetic, antioxidant, and catalytic properties ( Crans et al, 2019 ; Assey and Mgohamwende, 2020 ). However, vanadium and chromium-based complexes’ antibacterial and anticancer activity is rarely studied ( Singh and Gupta, 2008 ; Al-Hazmi et al, 2020 ).…”

“…In this context, exploring metal-based nanoparticles, such as Zinc Chromium vanadate nanoparticles (VCrZnO4 NPs), holds excellent promise. VCrZnO4 NPs exceptional physical and chemical properties make them suitable candidates for antibacterial and anticancer applications ( Crans et al, 2018 ; Assey and Mgohamwende, 2020 ; Suma et al, 2020 ). By bridging the knowledge gap and advancing our understanding of the biological activities of vanadium and chromium-based complexes, this study presents an innovative approach for synthesizing VCrZnO4 NPs using a one-pot solvothermal reaction with tetramethylammonium hydroxide (TMAOH) as both a reducing agent and a structure-directing agent.…”

Synthesis, crystal structure, and antidiabetic property of hydrazine functionalized Schiff base: 1,2-Di(benzylidene)hydrazine

“…The functionalization of hydrazine improves the efficiency of the materials and may create new properties in it. Among various functionalizations, one with Schiff base is trending due to the diverse properties of Schiff base including antibacterial [13,14], antifungal [15][16][17], antioxidant [18][19][20], antiviral [21], antitumor [22], anti-inflammatory [23,24], biomimics [25], luminescence [26] and catalytic activity [27][28][29]. A brief literature survey shows that Biswas et al has successfully designed a Schiff base functionalized with hydrazine and employed it for the synthesis of nanoaggregates that showed blue emission properties [30].…”