A new adenovirus serotype of bovine origin

Darbyshire, J.H.; Dawson, Patrick; Lamont, P. H.; Ostler, DC; Pereira, H. G.

doi:10.1016/0021-9975(65)90038-1

Cited by 57 publications

(23 citation statements)

References 11 publications

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“…This is the first isolation of bovine adenovirus ever reported in Japan. Two serological types, 1 and 2, of bovine adenovirus have been isolated from feces of cattle by Klein and associates [14,15] in the United States, and type 3 was described by Darbyshire et al [6] in England. More recently, adenovirus strains were recovered from cattle in Hungary [1,3], and were grouped into two further types, 4 and 5 [4].…”

Section: Discussionmentioning

confidence: 99%

“…More recently, adenovirus strains were recovered from cattle in Hungary [1,3], and were grouped into two further types, 4 and 5 [4]. These viruses have been included in the group of adenovirus on the basis of the formation of characteristic intranuclear inclusion bodies, the production of a group-specific adenovirus antigen; however, their chemical and physical characterization has been inadequate [1,3,6]. In conformance with these recognized adenoviruses, our isolates produced intranuclear inclusion bodies in cultured bovine testicular cells, and group-specific adenovirus antigen.…”

Section: Discussionmentioning

confidence: 99%

“…The two isolates, Nagano-6 and Ehime, Nagano virus is similar to bovine adenovirus types 4 and 5 in that they all grow in bovine testicle cells but not in bovine kidney cells [1,3]; types 1, 2 and 3 have been reported to grow in both types of cell cultures [6,[13][14][15]. Nagano virus was found to agglutinate rat erythrocytes very poorly, but not erythrocytes of sheep, goat, cattle, horse, guinea pig, hamster, chicken, and mouse.…”

Section: Discussionmentioning

confidence: 99%

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Bovine Adenovirus

Tanaka

Inaba

Ito

et al. 1968

Japanese Journal of Microbiology

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Two adenovirus strains were isolated in calf testicle cell cultures from blood specimens of cattle in Japan. This is the first isolation of bovine adenovirus reported in Japan. The isolates were antigenically similar to each other and distinct from the hitherto described serotypes 1, 2 and 3 of bovine adenovirus. Unfortunately, bovine adenovirus types 4 and 5 were not available for comparison, and hence, until the matter is settled, the virus will be called "Bovine adenovirus type Nagano". Nagano virus was identified as adenovirus on the bases of the inhibitory effect of 5-iodo-2'-deoxyuridine on virus replication, ether-resistance, effect of temperature and pH on infectivity, and fine structure of the virus particle. The virus grew and formed intranuclear inclusion bodies, a characteristic of adenovirus, in bovine testicle cells but not in bovine kidney cells. The virus agglutinated rat erythrocytes very poorly, but not sheep, goat, cattle, horse, guinea pig, hamster, chicken, and mouse cells. The virus produced adenovirus group-specific antigen in cell cultures. Sero-negative calves were readily infected with the virus by the intravenous, subcutaneous, oral or intranasal routes of inoculation. The infected animals produced antibodies and showed a mild clinical reaction comprised of rhinorrhea, diarrhea and a degree of pyrexia; low-titered viremia of short duration and leukopenia were also observed. A serologic survey indicated wide-spread dissemination of the virus among Japanese cattle, but further studies are needed to determine the etiologic significance of the virus in the natural disease in cattle.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Bovine Adenovirus

Tanaka

Inaba

Ito

et al. 1968

Japanese Journal of Microbiology

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“…10) and 2 (No. 19) [7,8] were obtained from American Type Culture Collection and type 3 (WBRI) [4] was obtained from Dr. J. H. Derbyshire, Central Veterinary Laboratory, Weybridge, England. The Los Angeles strain of infectious bovine rhinotracheitis virus [9] was used as infected BT culture fluid with a titer of 106.0 TCID50/0.1 ml.…”

Section: Methodsmentioning

confidence: 99%

Bovine Adenovirus

Inaba

Tanaka

Sato

et al. 1968

Japanese Journal of Microbiology

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Nine strains of an adenovirus serotype were recovered in bovine testicle cell cultures from Japanese cattle suffering with an acute febrile illness accompanied by rhinorrhea and diarrhea. The isolated virus was shown to have the physicochemical properties of the adenovirus group such as the nucleic acid type, the size and ultrastructure of the virion, and the resistance to ether and chloroform. The isolated virus produced eosinophilic intranuclear inclusion bodies characteristic of adenoviruses and the group specific antigen of adenovirus in bovine testicle cell culture. According to the results of crossneutralization tests the isolated virus represents a serological type distinct from bovine adenovirus types 1, 2 and 3 and from the Nagano virus. The isolated virus agglutinated erythrocytes of cattle, sheep, goat, 'guinea pig, rat, hamster and mouse, but not those of vervet monkey, horse, goose and chicken. HI test using cattle erythrocytes corroborated the results of serological typing by neutralization tests.

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“…Madin-Darby bovine kidney (MDBK) cells were maintained in medium α-MEM with 10 % newborn calf serum (BRL). BAV3 (strain WBR-1) (Darbyshire et al, 1965) was kindly provided by B. Derbyshire, University of Guelph, Guelph, Canada.…”

Section: Methodsmentioning

confidence: 99%

Transcription units of E1a, E1b and pIX regions of bovine adenovirus type 3.

Zheng¹,

Graham

Prevec

1999

Journal of General Virology

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The major mRNA species in the E1 region of the genome of bovine adenovirus type 3 (BAV3) have been defined by using a combination of PCR, 5h RACE, Northern analysis and DNA sequencing. Independent transcription initiation sites were identified for each of the E1a, E1b and protein IX (pIX) transcription units, but all mRNA species terminated at the same poly(A) addition site immediately downstream of the pIX open reading frame. Thus, the BAV3 E1 region, which consists of the E1a and E1b genes together with that for pIX, functions as a nested overlapping transcription unit. One major mRNA species encoding the E1a protein was found and two mRNAs encoding E1b species, the smaller of which encodes the E1b 17K protein alone and the larger encodes both 17K and 47K E1b proteins, were identified. One mRNA species encodes pIX. The E1a transcript, encoding the predicted 214 residue E1a protein, has four exons. The smaller E1b mRNA has two exons, the second of which corresponds to the last exon of E1a. No introns were detected in the larger E1b mRNA that encodes both the E1b 17K and 47K proteins nor in the mRNA encoding pIX. The relative times of appearance of the mRNAs from the E1-pIX gene region following infection of bovine cells with BAV3 was determined.

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A new adenovirus serotype of bovine origin

Cited by 57 publications

References 11 publications

Bovine Adenovirus

Bovine Adenovirus

Bovine Adenovirus

Transcription units of E1a, E1b and pIX regions of bovine adenovirus type 3.

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