This study presents the analysis and design of a single phase power factor correction (PFC) scheme using a DC-DC single ended primary inductance converter with genetic algorithm (GA)-tuned proportional integral (PI) controllers. A systematic off-line design approach using GA for optimising the parameters of the PI controller is proposed and the performance is compared with the conventional Z-N tuned PI controller. The steady-state and transient responses of the converter subjected to a change in the load, set point and line variations are investigated. The performance analysis of the proposed converter in continuous conduction mode is made for the above-mentioned methods using Matlab/Simulink-based simulation studies and experimental set up. Results reveal that the GA-tuned PI controller yields superior performance to the Z-N tuned PI controller in terms of power factor, percentage total harmonic distortion, regulated output voltage for the variations in line, load and efficient tracking of output voltage for a change in the reference voltage.