A new abietane diterpenoid from the roots of Tripterygium regelii

Abstract

A new abietane diterpenoid, tripterregeline A (1), together with six known diterpenoids (2-7), were isolated from the roots of Tripterygium regelii. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparison with data reported in the literature. All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Compounds 1-7 showed significant inhibitory effects against various human cancer cell lines with IC values ranging from 0.58 to 21.06 μM.

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“…Lastly, Triptobenzene D was measured by proton signals at chemical shifts of 0.83 (m, 6H), 0.97 (m, 1H), 1.10 (m, 1H), 1.20 (m, 5H), 1.41 (s), 1.45 (s), 1.53 (s, 1H), 1.59 (s, 1H), 1.88 (s, CH3), 1.93 (d, J = 5.7 Hz, 1H), 2.46 (pent, J = 1.8 Hz, 2H), 3.12 (d, J = 2.4 Hz, 3H), 4.09 (d, J = 5.2 Hz, 1H), 6.69 (m, 0H), 7.01 (m, 0H), 7.06 (s), dan 7.09 (s). Triptobenzene D is one of the diterpenoids that can be isolated from Tripterygium wilfordii [ 8 ] and the Celastraceae plant [ 37 ].…”

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“…Plants 2022, 11, x FOR PEER REVIEW Tripterregeline A 121 was isolated from the roots of Tripterygium regeli traceae), which is naturally distributed throughout East Asia. Tripterregeline A evaluated for its cytotoxicity against the HL-60, SMMC-7721, A549, MCF-7, and cell lines and showed stronger inhibitory activities than those of cisplatin, with IC ranging from 0.58 to 5.82 μM [74] (Figure 50).…”

“…Trigohowimine A 122 showed significant cell growth inhibitory activities the HL-60, SMMC-7721, A54, MCF-7, and SW480 cell lines, with IC50 values of 0 5.64, 6.26, and 8.53 μM, respectively, better than the positive control cisplatin [75 50). [74] and trigohowimine A 122 [75].…”