Recent advances in 3CL&amp;lt;sup&amp;gt;pro&amp;lt;/sup&amp;gt; inhibitors from Chinese herbs

Hu, Qing; Zhu, Guanghao; Xiong, Yuan; Zhang, Yani; Zhang, Yiwen; Huang, Ping; Ge, Guangbo

doi:10.1360/ssv-2021-0394

Cited by 1 publication

(2 citation statements)

References 112 publications

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“…It’s active ingredients such as isoquercitrin can bind with tryptophan residues of MERS-CoV 3CLpro and inhibit the activity. Polygonin and resveratrol have high affinity with SARS-CoV-2 3CLpro, SARS-CoV 3CLpro and MERS-CoV 3CLpro, and are potential broad-spectrum inhibitors of coronavirus [ 71 ].…”

Section: Introductionmentioning

confidence: 99%

“…Promotion of Th1-type cell expression and enhances immunity [ 21 , 75 ] Ethanolic extract of Scutellaria baicalensis Scutellaria baicalensis Baicalin and baicalein Inhibited SARS-CoV-2 3CLpro activity and SARS-CoV-2 replication [ 76 ] Salvia Miltiorrhiza Extract Salvia Miltiorrhiza Tanshinones (dihydrotanshinones, etc.) Inhibit TLR4/NF-κB mediated inflammatory response and play an anti-acute lung injury role and inhibit the activity of SARS-CoV 3CLpro and prevent virus replication [ 71 , 73 ] …”

Section: Introductionmentioning

confidence: 99%

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Advances in natural product anti-coronavirus research (2002-2022)

Chen

Ding

2023

Chin Med

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COVID-19 is a severe acute respiratory syndrome caused by coronavirus that has triggered acute respiratory infections in countries around the world. In the last 20 years, there have been several outbreaks of coronaviruses, which have had a tremendous impact on productive life and globalization. Since coronaviruses are mutagenic and highly susceptible to mutation, there are no specific drugs against coronaviruses. Medicines made from natural products gains worldwide attention, and the mechanism and effectiveness of natural products for the treatment of coronavirus-related diseases have received much attention after the global pandemic of COVID-19 in 2020. The vitro research results and clinical data from various countries have shown protective effects of good effects against coronaviruses. This review summarizes representative natural products for the treatment of coronavirus-related diseases in the past 20 years, and demonstrates the promising prospects of natural products against coronavirus-related diseases by listing herbal formulas, Chinese patent medicines and natural small molecule compounds and their therapeutic mechanisms, providing references for subsequent related studies.

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Section: Introductionmentioning

confidence: 99%