A new 4-arylflavan from the pericarps of <i>Horsfieldia motleyi</i> displaying dual inhibition against α-glucosidase and free radicals

Ramadhan, Rico; Kusuma, Irawan Wijaya; Amirta, Rudianto; Worawalai, Wisuttaya; Phuwapraisirisan, Preecha

doi:10.1080/14786419.2017.1378204

Cited by 11 publications

(12 citation statements)

References 16 publications

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“…The ABTS •+ scavenging activity of the ten ethnomedicinal extracts was determined based on the method developed by Ramadhan et al (2018) with some modifications. The free radical ABTS was generated by the reaction between ABTS in water and 2.45 mM potassium persulfate, and it was stored in a dark room for 12 hours.…”

Section: Abts Radical Inhibitory Activitymentioning

confidence: 99%

The potency of selected ethnomedicinal plants from East Kalimantan, Indonesia as antidiabetic agents and free-radical scavengers

et al. 2022

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Abstract. Ramadhan R, Phuwapraisirisan P, Amirta R, Darmawan MFB, Ul-Haq K, Kusuma IW, Suwito H, Abdulgani N, Mukhdlor A, Saparwadi. 2022. The potency of selected ethnomedicinal plants from East Kalimantan, Indonesia as antidiabetic agents and free-radical scavengers. Biodiversitas 23: 2225-2231. Ten ethnomedicinal plant extracts from East Kalimantan flora, traditionally used to treat blood sugar levels and other diabetes-related diseases, were examined in vitro for their antidiabetic and free radical scavenging activities by inhibiting rat alpha-glucosidase and several free radicals such as DPPH, ABTS, and Nitric oxide respectively. Out of the ten plant species investigated for their antidiabetic activity against maltase and sucrase rat alpha-glucosidase, three exhibited the strongest ?-glucosidaseinhibitory activity with maltose as a substrate, namely extracts of Garcinia nervosa, Syzygium caudatilimbum, and Shorea balangeran with IC50 values of 0.046; 0.037; 0.045 mg/mL. Meanwhile, quercetin as a positive control appeared to have a comparable IC50value. Furthermore, among the ten extracts, Syzygium caudatilimbum, Shorea balangeran, and Ixora javanica showed good inhibition against sucrase rat alpha-glucosidase. Moreover, the antioxidant test showed that the ten methanol extracts of plants from East Kalimantan have an antioxidant activity indicated by IC50values. The present study confirms that the ethnopharmacological use of selected plants from East Kalimantan might have potential as an antidiabetic and natural antioxidant.

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Section: Abts Radical Inhibitory Activitymentioning

confidence: 99%

The potency of selected ethnomedicinal plants from East Kalimantan, Indonesia as antidiabetic agents and free-radical scavengers

et al. 2022

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“…Both flavonoid such as apigenin, morin, myricetin and non-flavonoid compounds such as calystegines may show α-glucosidase inhibitory activity (AGL ocković et al, 2013;Zeng et al, 2016 . For example, α-glucosidase α-Glu) inhibitors such as acarbose, miglitol and voglibose are able to suppress postprandial hyperglycemia, a prominent and early symptom of type 2 diabetes (Basha and Prasada Rao, 2017;Bailey, 2003;Potipiranun et al, 2017;Ramadhan et al, 2017). Most often natural α-glucosidase inhibitors show fewer and milder side effects (abdominal distention, flatulence and possibly diarrhea) than synthetic ones (Adisakwattana et al, 2009;Su et al, 2018;Wang et al, 2017;Vinholes et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Impact of vinification procedure on fruit wine inhibitory activity against α-glucosidase

et al. 2018

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α-Glucosidase inhibitory activity (AGL) of fruit wine samples made from blueberry, black chokeberry, blackberry, raspberry and sour cherry cultivars grown in Serbia was studied using an microvinification procedure. More precisely, both sugar and enzyme were added to the fruit must 2 before fermentation for half of the samples. This increased the extraction of phenolic compounds.All the samples showed higher bioactivity compared to acarbose, the compound used as a positive control. Blueberry (IC 50 ~27 ± 1 µg/ml) and black chokeberry (IC 50 ~28 ± 1 µg/ml) wine samples had the highest values regardless of the vinification method. In addition to this, chlorogenic and caffeic acids were recognised as their key AGL bioactives. Taken all together, the fruit wine samples or their lyophilised extracts may be considered as complementary medicine supplements of potential interest for the control of postprandial hyperglycemia.

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“…Acarbose, miglitol and voglibose are well known α-glucosidase inhibitors capable of suppressing postprandial hyperglycaemia [37][38][39][40]. Indeed, the overall effect of α-glucosidase inhibition may prevent the development of diabetes [41].…”

Section: Discussionmentioning

confidence: 99%

Low-Energy Strawberry Fruits of Joly Cultivar, the First Step Towards a Novel, Food-Based Solution for the Obese Population

et al. 2019

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This study aimed to produce low-energy strawberries of the Joly cultivar by breeding them under different growing conditions. The efficacy of such a process was screened by the means of common physico-chemical parameters underpinned with the findings of elementary chemical analysis. The preferred strawberry breed line (treated with microbiological fertiliser of choice) showed both a decreased energy value (130 ± 6 kJ/100 g or 31.07 kcal) and an increased water content (91.0 ± 7.3 g/100 g). Due to a rich content of phenolic compounds (Total Phenolic Content /TPC/ 4184 ± 39 mg GAE/kg; Total Anthocyanin Content /TAC/ 394 ± 4 mg C3GE/kg), it also exhibited potent antioxidant activity (0.110 ± 0.008 %/μL, HPMC /Hydroxo-Perhydroxyl Mercury(II) Complex/) assay; EC50 = 2.01 ± 0.10 µg and ARP = 0.50 ± 0.05 µg−1, DPPH assay). Finally, the polyphenolic extract of the same breed line showed high anti-α glucosidase activity (IC50 = 19 ± 1 µg/mL), being more than four-fold active compared to acarbose (IC50 = 78 ± 4 µg/mL), the anti-diabetic drug used as a positive control. Taken all together, the utilisation of microbiological fertiliser (Bacillus sp.) in tunnels might be recommended for the breeding of low-energy strawberries of the Joly cultivar (the starting point for developing of novel functional foods targeting the obese population) in the same or similar agricultural conditions, if further studies confirm its likely potential and credibility.

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A new 4-arylflavan from the pericarps of Horsfieldia motleyi displaying dual inhibition against α-glucosidase and free radicals

Cited by 11 publications

References 16 publications

The potency of selected ethnomedicinal plants from East Kalimantan, Indonesia as antidiabetic agents and free-radical scavengers

The potency of selected ethnomedicinal plants from East Kalimantan, Indonesia as antidiabetic agents and free-radical scavengers

Impact of vinification procedure on fruit wine inhibitory activity against α-glucosidase

Low-Energy Strawberry Fruits of Joly Cultivar, the First Step Towards a Novel, Food-Based Solution for the Obese Population

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