The potency of selected ethnomedicinal plants from East Kalimantan, Indonesia as antidiabetic agents and free-radical scavengers

Ramadhan, Rico; Phuwapraisirisan, Preecha; Amirta, Rudianto; DARMAWAN, MUHAMMAD FADIL BAGAS; UL-HAQ, KAUTSAR; Kusuma, Irawan Wijaya; Suwito, Hery; Abdulgani, Nurlita; MUKHDLOR, AHMAD; SAPARWADI, SAPARWADI

doi:10.13057/biodiv/d230458

Cited by 6 publications

(6 citation statements)

References 24 publications

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“…This result is correlated with its traditional use as antidiabetic. A similar study also conducted by Ramadhan (2022) confirmed the ethnopharmacological use of selected plants from East Kalimantan might have potential as an antidiabetic and natural antioxidant. This study has limitations on the interpretation of the pharmacological activity and phytochemical compounds of all cited plants.…”

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confidence: 59%

Ethnomedicinal study, phytochemical characterization, and pharmacological confirmation of selected medicinal plant on the northern slope of Mount Wilis, East Java, Indonesia

et al. 2022

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Abstract. Bhagawan WS, Suproborini A, Putri DLP, Nurfatma A, Putra RT. 2022. Ethnomedicinal study, phytochemical characterization, and pharmacological confirmation of selected medicinal plant on the northern slope of Mount Wilis, East Java, Indonesia. Biodiversitas 23: 4303-4313. The traditional usage of plants in ethnomedicine is a valuable resource for human primary healthcare. The effectiveness of herbal medicines and the creation of new drugs are proven by pharmacological and phytochemical verification. This study documented the traditional ethnomedicine knowledge (TEK) on the northern slope of Mount Wilis community in utilizing medicinal plants and revealed the ethnopharmacology relevance of selected medicinal plants. Data on TEK and its practices were collected through in-depth and semi-structured interviews with informants who were selected using purposive sampling and snowball sampling techniques. The phytochemical compounds of the selected medicinal plant were identified using the UPLC-Qtof-MS/MS instrument, while their pharmacological activity was measured in antibacterial tests. The results showed that the community continued to apply TEK that had been passed down by the previous generation through a method called Gethok Tular. The medicinal plant species in the study area were diverse, 82 species from 39 families with various modes of preparation were used to treat seven disease categories. Tithonia diversivolia had the highest use value of 0.65 and it contained 23 phytochemical compounds. In addition, this plant has high pharmacological potential for antibacterial agents.

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confidence: 59%

Ethnomedicinal study, phytochemical characterization, and pharmacological confirmation of selected medicinal plant on the northern slope of Mount Wilis, East Java, Indonesia

et al. 2022

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“…The α-glucosidase inhibitory activity of Diospyros sp. extract was examined using the chromogenic method described by Ramadhan et al (2022) with slight modification. Briefly, various concentrations of extract (20 μL) were added with a phosphate buffer with pH 6.8, followed by 50 μL of α-glucosidase.…”

Section: In Vitro Antidiabetic Activity α-Glucosidase Inhibition Assaymentioning

confidence: 99%

Phytochemical analysis in conjunction with in vitro a-glucosidase inhibitory and antioxidant activities of three Diospyros species from East Kalimantan, Indonesia

RAMADHAN,

ROSYIDAH,

FIRDAUS

et al. 2023

Biodiversitas

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Abstract. Ramadhan R, Rosyidah N, Firdaus YFH, Kurnia IT, Lestari DA, Phontree K, Phuwapraisirisan P, Riyadi L, Rahman A, Abdulgani N, Maretna SA, Fadhila KN. 2023. Phytochemical analysis in conjunction with in vitro a-glucosidase inhibitory and antioxidant activities of three Diospyros species from East Kalimantan, Indonesia. Biodiversitas 24: 4783-4790. Locals who live in forested areas have long relied on Non-Timber Forest Products (NTFPs) for their traditional ceremonies, food, and medicine. As non-timber forest products, medicinal plants are of interest since they are used by locals in East Kalimantan regions, Indonesia, for local traditional medicine. In the search for new potential antidiabetics and antioxidants created from natural resources, the authors concentrated on medicinal plants traditionally used in East Kalimantan and ethnopharmacological data. The purpose of this study is to evaluate the dual roles of non-timber forest products, such as three Diospyros L. species, in a-glucosidase inhibition, antioxidant (free radical scavenging activity against DPPH and ABTS), and CUPRAC in-vitro activities. This study showed that the strongest a-glucosidase inhibitory activity was found in ethyl acetate and ethanol residue extracts of Diospyros celebica Bakh., with IC50 values of 4.5804±0.14 ug/mL and 3.8236±0.19 ug/mL respectively, which were more potent than quercetin as a positive standard. Additionally, the antioxidant test revealed that leaf extracts of three Diospyros species from East Kalimantan are excellent sources of natural antioxidants, as demonstrated by the SC50 values. The findings of this study support and validate the use of leaf extracts of three Diospyros species in traditional East Kalimantan medicine.

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“…East Kalimantan is renowned for its biodiversity and natural resources, including aromatic plants and medicinal plants. The potential of East Kalimantan's medicinal plants and essential oils has been extensively researched, including its potential to be developed as antioxidants, antibacterials, anticancer agents, and other substances (Kuspradini et al 2019;Ramadhan et al 2022). However, using plants as essential oils that originate from East Kalimantan has been widely practiced.…”

Section: Introductionmentioning

confidence: 99%

Potential antibacterial and antioxidant activities of ten essential oils from East Kalimantan, Indonesia

Aryani

Kusuma

MELIANA³

et al. 2023

Biodiversitas

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Abstract. Aryani F, Kusuma IW, Meliana Y, Sari NM, Kuspradini H. 2023. Potential antibacterial and antioxidant activities of ten essential oils from East Kalimantan, Indonesia. Biodiversitas 24: 665-672. This study aimed to evaluate ten aromatic essential oils' antibacterial and antioxidant activity. Ten aromatic herbs were distilled using the water and steam distillation method. The essential oils obtained was tested for its physical properties, color, refractive index, and specific gravity. The refractive index was measured using a refractometer. On the other hand, specific gravity was measured using a pycnometer. Antioxidant activity testing using the free radical DPPH (2,2-diphenyl-1-picrylhydrazyl) and ascorbic acid was used as the control. Antibacterial activity testing using the agar diffusion method and pathogenic bacteria, namely Salmonella typhi, Escherichia coli, Propionibacterium acnes, and Staphylococcus aureus. Chloramphenicol was used as a positive control and acetone as a negative control. The results obtained essential oils with a slightly yellowish to brownish-yellow color. The highest refractive index and specific gravities were Syzygium aromaticum oil, and the smallest was Litsea elliptica and Eucalyptus pellita oils. The results of the antioxidant activity test carried out at a concentration of 500 µg/mL range from 4.82 % to 85.06 % inhibition and showed that the highest inhibition was Cymbopogon citratus and Syzygium aromaticum by 55.76 % and 85.06%, respectively. Antibacterial activity of ten essential oils showed a varied inhibition zone (0-60 mm) against S. typhi, E. coli, P. acnes, and S. aureus. The oil from Cymbopogon citratus and Citrus hystrix had the highest activity against S. typhi (60 and 21.67 mm, respectively), E. coli (60 and 20.33 mm, respectively), P. acnes (60 and 31.11 mm, respectively) and S. aureus (60 mm and 17.89 mm, respectively). The research results showed that the essential oils in this study had the potency for development as a natural antibacterial and antioxidants agents.

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The potency of selected ethnomedicinal plants from East Kalimantan, Indonesia as antidiabetic agents and free-radical scavengers

Cited by 6 publications

References 24 publications

Ethnomedicinal study, phytochemical characterization, and pharmacological confirmation of selected medicinal plant on the northern slope of Mount Wilis, East Java, Indonesia

Ethnomedicinal study, phytochemical characterization, and pharmacological confirmation of selected medicinal plant on the northern slope of Mount Wilis, East Java, Indonesia

Phytochemical analysis in conjunction with in vitro a-glucosidase inhibitory and antioxidant activities of three Diospyros species from East Kalimantan, Indonesia

Potential antibacterial and antioxidant activities of ten essential oils from East Kalimantan, Indonesia

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