A Nested Case-Control Study of Midgestation Vitamin D Deficiency and Risk of Severe Preeclampsia

Baker, Arthur M.; Haeri, Sina; Camargo, Carlos A.; Espinola, Janice A.; Stuebe, Alison M.

doi:10.1097/ogx.0b013e3182153c74

Cited by 30 publications

(51 citation statements)

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“…In three studies, women who developed preeclampsia were found to have lower levels of vitamin D than women who did not with levels less than 50 nmol/l associated with a five-fold increased risk of severe preeclampsia. [9][10][11] In our study findings revealed that maternal vitamin D deficiency in pregnancy is not significantly associated with elevated risk for preeclampsia. Out of 21 patients that had gestational hypertension, only 8 had vitamin D deficiency.…”

Section: Pre-eclampsiamentioning

confidence: 51%

A study of vitamin D levels and associated deficiency in pregnancy and its effect on maternal and fetal outcome

Dave

Verma

Jain

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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Background: From conception the embryo is dependent on the mother for all nutritional requirements until birth. Vitamin D deficiencies have adverse effect on pregnancy outcome result in poor growth, prematurity, NTD, even congenital anomalies. The aim and objectives of the study was to assess the prevalence of deficiencies among pregnant woman attending M.Y. Hospital and assess the correlation with the pregnancy complications.Methods: Total 110 patients were studied for vitamin d levels and associated obstetrical complications and risk factors over a period of six months. 53 pregnant women were found to be deficient with vitamin D.Results: 53 pregnant women out of total of 110 were deficient in vitamin D levels. Maximum patients belonged to group (21-30yr) of age. Vitamin D deficiency was more in housewives (65.3%) and in urban(86.8%). Low birth weight<2.5kg were born 50(45.5%) and 2 IUD. 2 were diagnosed NTD in USG reports. 80% low birth weight babies were born in vitamin D deficient women.Conclusions: Our study fails to show a causal relation between low vitamin D level and adverse maternal and fetal outcome in terms of preeclampsia, cesarean delivery, oligo and diabetes. There was a relation between vitamin D deficiency and low birth weight babies.

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Section: Pre-eclampsiamentioning

confidence: 51%

A study of vitamin D levels and associated deficiency in pregnancy and its effect on maternal and fetal outcome

Dave

Verma

Jain

et al. 2016

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

show abstract

“…This is comparable to the study done by Baker et al who found that mid gestation maternal 25(OH)D concentration was lower in women who subsequently developed severe preeclampsia compared with controls. 29 The present study revealed a significant association between preeclampsia and vitamin D deficiency. Vitamin D deficiency was significantly higher in pregnant women with preeclampsia compared with the control group (95.5% vs 68.7%), which is consistent with a metaanalysis showing a significant association between 25(OH)D deficiency.…”

Section: Discussionmentioning

confidence: 60%

Hypovitaminosis D in pregnancy and its correlation with preeclampsia and gestational diabetes mellitus

Kumari

Mitra

Tiwari

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: Hypovitaminosis D has been associated with a number of adverse pregnancy outcomes, and has been recognised as a public health concern. The objective of this study was to determine the impact of Vitamin D deficiency on maternal complications like gestational diabetes mellitus (GDM) and preeclampsia (PE) among pregnant women.Methods: This was a case control study undertaken at antenatal clinics and indoor of BRD Medical College, Gorakhpur, Uttar Pradesh, India. Two maternal blood samples, one at <20 weeks and other at term along with cord blood at delivery were taken. Patients were classified into preeclampsia (n=60), gestational diabetes mellitus (n=35) and control group (n=180) after abstracting past medical records at delivery. Vitamin D was estimated by 25- Hydroxyvitamin D125 RIA kit and categorized according to ACOG criteria. Statistical analysis was done by using chi square test, binary logistic regression and Pearson’s correlation coefficient to compare between two variables. P<0.05 was considered statistically significant.Results: Out of 275 women included in the study, 78% of women were Vitamin D deficient. Mean serum vitamin D was significantly lower among preeclamptic women 11.53±6.22 ng/ml and GDM women 12.62±6.69 ng/ml as compared to controls 24.25±14.44 ng/ml (median=18.2 ng/ml) (P<0.05). Vitamin D deficiency was significantly higher in pregnant women GDM (94.28% vs 68.3%) and preeclampsia (96.67% vs 68.3%) when compared to uncomplicated group.Conclusions: Maternal vitamin D deficiency is highly prevalent in early pregnancy and is significantly associated with elevated risk for GDM and preeclampsia.

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“…This is similar to study done by Baker et al who found that mid gestation maternal 25(OH) vitamin D concentration was lower in women who subsequently developed severe preeclampsia compared with controls. 23 In a case-cohort study it was found that maternal vitamin D deficiency may be a risk factor for severe pre eclampsia, but it is not associated with pre eclampsia overall or its mild subtypes. 9 No significant difference was found in vitamin D status among both mild and severe subtypes of pre eclampsia.…”

Section: Resultsmentioning

confidence: 99%

“…Because there is no universally acceptable definition of vitamin D deficiency, we used cut off points suggested recently by some studies. 23,24,26 Serum samples were drawn at similar gestational ages in both the groups.…”

Section: Methodsmentioning

confidence: 99%

Association of vitamin D deficiency with occurrence of pre eclampsia among inpatients of tertiary care centre, Gorakhpur, Uttar Pradesh, India

Singh

Mishra

Aditya

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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A Nested Case-Control Study of Midgestation Vitamin D Deficiency and Risk of Severe Preeclampsia

Cited by 30 publications

References 0 publications

A study of vitamin D levels and associated deficiency in pregnancy and its effect on maternal and fetal outcome

A study of vitamin D levels and associated deficiency in pregnancy and its effect on maternal and fetal outcome

Hypovitaminosis D in pregnancy and its correlation with preeclampsia and gestational diabetes mellitus

Association of vitamin D deficiency with occurrence of pre eclampsia among inpatients of tertiary care centre, Gorakhpur, Uttar Pradesh, India

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