This paper provides an experimental investigation into the use of leading edge serrations as a means of reducing the broadband noise generated due to the interaction between the aerofoil's leading edge (LE) and impinging turbulence. Experiments are performed on a flat plate in an open jet wind tunnel. Grids are used to generate isotropic homogeneous turbulence. The leading edge serrations are in the form of sinusoidal profiles of wavelengths, λ, and amplitudes, 2h. The frequency and amplitude characteristics are studied in detail in order to understand the effect of LE serrations on noise reduction characteristics and are compared with straight edge baseline flat plates. Noise reductions are found to be insignificant at low frequencies but significant in the mid frequency range (500 Hz to 8 kHz) for all the cases studied. The flat plate results are also compared to the noise reductions obtained on a serrated NACA-65 aerofoil with the same serration profile. Noise reductions are found to be significantly higher for the flat plates with a maximum noise reduction of around 9 dB compared with about 7 dB for the aerofoil. In general, it is observed that the sound power reduction level (∆PWL) is sensitive to the amplitude, 2h of the LE serrations but much less sensitive to the serration wavelength, λ. Thus, this paper sufficiently demonstrates that the LE amplitude act as a key parameter for enhancing the noise reduction levels in flat plates and aerofoils.

Maternal midgestation vitamin D deficiency was associated with increased risk of severe preeclampsia. Vitamin D deficiency may be a modifiable risk factor for severe preeclampsia.

An aerofoil leading-edge profile based on wavy (sinusoidal) protuberances/tubercles is investigated to understand the mechanisms by which they are able to reduce the noise produced through the interaction with turbulent mean flow. Numerical simulations are performed for non-lifting flat-plate aerofoils with straight and wavy leading edges (denoted by SLE and WLE, respectively) subjected to impinging turbulence that is synthetically generated in the upstream zone (freestream Mach number of 0.24). Full threedimensional Euler (inviscid) solutions are computed for this study thereby eliminating self-noise components. A high-order accurate finite-difference method and artefact-free boundary conditions are used in the current simulations. Various statistical analysis methods, including frequency spectra, are implemented to aid the understanding of the noise-reduction mechanisms. It is found with WLEs, unlike the SLE, that the surface pressure fluctuations along the leading edge exhibit a significant source cut-off effect due to geometric obliqueness which leads to reduced levels of radiated sound pressure. It is also found that there exists a phase interference effect particularly prevalent between the peak and the hill centre of the WLE geometry, which contributes to the noise reduction in the mid-to high-frequency range.

Objective To document perinatal outcomes following use of the 'Solomon technique' in the selective photocoagulation of placental anastomoses for severe twin-twin transfusion syndrome (TTTS). Methods (adjusted odds ratio (aOR), 11.35 (95% CI,; P = 0.0007) and overall neonatal survival rate (aOR, 4.65 (95% CI,

Objective To determine associations between fetal lung and liver herniation volumes measured by magnetic resonance imaging (MRI) and mortality/need for extracorporeal membrane oxygenation (ECMO) in cases of isolated congenital diaphragmatic hernia (CDH

Background Vitamin D deficiency may contribute to impaired glucose metabolism. There are sparse data regarding vitamin D and the development of gestational diabetes (GDM). The objective of this study was to assess if first-trimester vitamin D deficiency is more prevalent in women later diagnosed with GDM compared with women with uncomplicated pregnancies. Methods We conducted a nested case-control study of pregnant women who had previously given blood for routine genetic multiple marker screening and subsequently delivered at a tertiary hospital between November 2004 and July 2009. From an overall cohort of 4225 women, 60 cases of GDM were matched by race/ethnicity with 120 women delivering at term (≥37 weeks) with uncomplicated pregnancies. Banked maternal serum was used to measure maternal 25-hydroxyvitamin D [25(OH)D]. Results The prevalence of first-trimester maternal vitamin D deficiency (defined as 25(OH)D <50 nmol/L) was comparable among women with GDM compared with controls (5/60 vs 8/120, p = 0.90). The median 25(OH)D level for all subjects was 89 nmol/L (interquartile range, 73–106 nmol/L). Seventy three percent (117/160) of the cohort had 25(OH)D levels ≥75 nmol/L. Conclusions In a cohort of pregnant women with mostly sufficient levels of serum 25(OH)D, vitamin D deficiency was not associated with GDM. Further studies are warranted with larger cohorts, especially in populations with lower levels of vitamin D.

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We assessed if first-trimester vitamin D deficiency is more prevalent in women who experienced a spontaneous preterm birth compared with women who delivered at term. We conducted a nested case-control study of pregnant women who had previously given blood for first-trimester combined screening for trisomy 21 and subsequently delivered at a tertiary hospital between November 2004 and July 2009. From an overall cohort of 4225 women, 40 cases of spontaneous preterm birth (≥23 0/7 and ≤34 6/7 weeks) were matched by race/ethnicity with 120 women delivering at term (≥37 0/7 weeks) with uncomplicated pregnancies. Banked maternal serum was used to measure maternal 25-hydroxyvitamin D [25(OH)D]. The prevalence of first-trimester maternal vitamin D deficiency [25(OH)D <50 nmol/L] was comparable among women who subsequently delivered preterm compared with controls (7.5% versus 6.7%, p=0.90). The median 25(OH)D level for all subjects was 89 nmol/L (interquartile range, 73 to 106 nmol/L). Seventy-three percent (117/160) of the cohort had sufficient vitamin D levels [25(OH)D ≥75 nmol/L]. In a cohort of pregnant women with mostly sufficient levels of first-trimester serum 25(OH)D, vitamin D deficiency was not associated with spontaneous preterm birth.