Association of vitamin D deficiency with occurrence of pre eclampsia among inpatients of tertiary care centre, Gorakhpur, Uttar Pradesh, India

Singh, Aradhana; Mishra, Sweta; Aditya, Vani; Srivastava, Reena

doi:10.18203/2320-1770.ijrcog20161280

Cited by 5 publications

(5 citation statements)

References 25 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There was no statistically significant difference in the vitamin D status in the preeclampsia and the control groups (p=0.94). Similarly, Singh et al [31] in India, reported from their published work that about 82.8% of preeclamptic and 31.25% of non preeclamptic patients were found deficient in vitamin D. Vitamin D levels were sufficient in only 17.2% of preeclamptic and 68.75% of non preeclamptic patients. However, they did not make any comment if this difference is statistically significant.…”

Section: Discussionmentioning

confidence: 86%

Association between serum hypovitaminosis D and preeclampsia: A nested case-control study

Okoro¹,

Udigwe²,

Eleje³

et al. 2023

Magna Sci. Adv. Res. Rev.

View full text Add to dashboard Cite

Background: Preeclampsia is a major complication of pregnancy and a major cause of perinatal and maternal morbidity and mortality. Vitamin D deficiency has been implicated in the aetiology and pathophysiology of preeclampsia. However, there is no uniformity in the findings of previous studies on the association between vitamin D and preeclampsia. Aims and Objectives: The study is aimed at determining the association between preeclampsia and maternal vitamin D deficiency. Materials and Methods: This nested case-control study was conducted among 158 pregnant women (78 preeclamptic women and 80 controls) with singleton pregnancies. Case participants were women with preeclampsia. The controls were matched pregnant women without preeclampsia. Their serum vitamin D levels were determined. Statistics: Continuous data was analysed using T-test. The statistical significance was inferred at p- value ≤0.05. Results: The prevalence of hypovitaminosis D in our study was 7.0% overall. The proportion of women with hypovitaminosis D was not significantly different between preeclampsia group and control group (7.7% vs 6.3% respectively; p=0.76). The mean serum concentration of vitamin D in the preeclamptic group was lower than that in the control group, however, the difference was not statistically significant (118.8±17.4nmol/L vs 129.0±19.7nmol/L, p=0.17). There was a weak association between gestational age and the level of serum vitamin D in both groups (r= 0.062 and r= -0.13 respectively). Conclusions: Hypovitaminosis D is not significantly associated with preeclampsia when compared with control. However, there was a weak association between gestational age and the level of serum vitamin D in both groups.

show abstract

Section: Discussionmentioning

confidence: 86%

Association between serum hypovitaminosis D and preeclampsia: A nested case-control study

Okoro¹,

Udigwe²,

Eleje³

et al. 2023

Magna Sci. Adv. Res. Rev.

View full text Add to dashboard Cite

show abstract

“…[16] Among the cases, 36 had severe preeclampsia, of which 24 women were noted with Vitamin D levels <20 ng/mL. This was established by Singh et al [1] However, a prospective case-control study by Arumaikannu et al stated that severe Vitamin D deficiency was not associated with severity of preeclampsia. [17] However, Akkar et al, in their prospective study, observed that maternal serum paraoxonase 1 level and Neutrophil to Lymphocyte Ratio distinguish severe preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

“…According to the WHO, it is reported to be seven times higher in developing countries (2.8% of live births) than in developed countries. [1] Various factors such as maternal internal milieu, immunological factors leading to endothelial disorder, angiogenesis factors, syncytiotrophoblastic microparticles, inflammatory mediators, and oxidative stress, play a role in the pathogenesis of preeclampsia. In addition, a poor diet with low calcium, magnesium, selenium, Vitamin A, and Vitamin C during pregnancy contributes to preeclampsia.…”

Section: Introductionmentioning

confidence: 99%

25(OH) Vitamin D Status among Females with Preeclampsia/Eclampsia: A Long-term Plight Readdressed

Nagarajan

2024

Apollo Medicine

View full text Add to dashboard Cite

Background: Preeclampsia is a life-threatening multisystem disorder of pregnancy which has been observed in 2%–10% of pregnancies. The prevalence of Vitamin D deficiency ranges from 15% to 80%. Deficiency of Vitamin D is associated with the development of preeclampsia. This study was done to find out the prevalence of Vitamin D deficiency among preeclamptic/eclamptic and normal pregnant females, to establish Vitamin D deficiency as a causal factor of preeclampsia, and to elucidate the relation between 25 (OH) Vitamin D status and the severe preeclampsia. Materials and Methods: Blood samples were collected from 50 normotensives (controls) and 50 hypertensive pregnant females with preeclampsia/eclampsia (cases), and 25 (OH) Vitamin D level was measured by chemiluminescence Immunoassay. Results: Among the preeclamptic/eclamptic group, 32 (64%) were noted with Vitamin D deficiency and 18 (36%) with Vitamin D insufficiency. In the control group, 30 (60%) pregnant women showed Vitamin D deficiency, 19 (38%) with Vitamin D insufficiency, and a sufficient level of Vitamin D was observed in one woman (2%). Conclusion: Although it is difficult to demonstrate the correlation between Vitamin D levels and preeclampsia, there is a widespread global prevalence of Vitamin D deficiency during pregnancy. Hence, Vitamin D supplementation can be included routinely in the antenatal care program in India.

show abstract

“…Ullah et al (2013)29 in his study concluded that the odds of developing preeclampsia and eclampsia increased upto 5 times in women with Vitamin D insufficiency. Similarly, Singh A et al (2016)30 and Mehmood et al (2016)31 (p-value=0.045) also found that most of the…”

mentioning

confidence: 81%

Association of Deficiency of Maternal Vitamin D Levels with Severity of Preeclampsia

Jindal

Sharma

2019

EpidemInt

View full text Add to dashboard Cite

Preeclampsia remains to be an important cause of maternal morbidity and mortality in both the developing and developed world. It is imperative to devise preventive strategies to reduce the burden of this disease. Vitamin D deficiency has emerged as an important inflammatory mediator in its pathogenesis. Objective: To find an association between the severity of preeclampsia and vitamin D deficiency amongst women attending a tertiary hospital in northern India. Material & Methods: this was a prospective comparative observational study. 125 women of preeclampsia and 125 controls were enrolled in the study after due written consent. The women of preelampsia were further divided into preeclampsia with or without severe features. After history, examination and relevant routine investigations, both groups underwent testing for vitamin D. Statistical analysis was conducted with the statistical package for the social science software version SPSS 20.0. The comparison of normally distributed continuous variables between the two groups was performed using Student's t test and for more than two groups comparison done through ANOVA test. For all statistical tests, a p value less than 0.05 was taken to indicate a significant difference/ association. Result: 80% subjects of study group were significantly more vitamin D deficient as compared to 68% of controls (p-value=0.03). Patients with preeclampsia with severe features had significantly lower levels of Vitamin D as compared to controls indicating that increased vitamin D deficiency was associated with increased severity of preeclampsia. None of the cases with severe preeclampsia had normal levels of Vitamin D. This was statistically significant (p-value=0.046). Conclusion: Severe pre-eclampsia was significantly associated with Vit D deficiency. Prevention of Vitamin D deficiency could be beneficial to prevent pre-eclampsia but community intervention studies are required.

show abstract

Association of vitamin D deficiency with occurrence of pre eclampsia among inpatients of tertiary care centre, Gorakhpur, Uttar Pradesh, India

Cited by 5 publications

References 25 publications

Association between serum hypovitaminosis D and preeclampsia: A nested case-control study

Association between serum hypovitaminosis D and preeclampsia: A nested case-control study

25(OH) Vitamin D Status among Females with Preeclampsia/Eclampsia: A Long-term Plight Readdressed

Association of Deficiency of Maternal Vitamin D Levels with Severity of Preeclampsia

Contact Info

Product

Resources

About