A Near-IR Reversible Fluorescent Probe Modulated by Selenium for Monitoring Peroxynitrite and Imaging in Living Cells

Yu, Fabiao; Li, Peng; Li, Guangyue; Zhao, G.; Chu, Tianshu; Han, Keli

doi:10.1021/ja202582x

Cited by 538 publications

(277 citation statements)

References 38 publications

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“…Han and co-workers [27][28][29][30] have shown that intermolecular interactions can have a significant effect on the photophysical and photochemical properties of chromophores. Hbonding to a range of chromophores is found to be significantly strengthened upon photoexcitation and has a significant effect on absorption and fluorescence spectra.…”

Section: Resultsmentioning

confidence: 99%

Interpreting the near-infrared reflectance of a series of perylene pigments

2013

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. and combination modes of fundamental IR vibrations appear to be more important in explaining the observed variations in NIR reflectance/absorbance. Aromatic groups lead to a small number of intense NIR bands, while alkyl groups generally lead to a greater number of less intense NIR bands. However, neighbouring group effects and/or a molecular dipole moment can substantially alter the intensity of these bands.

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Section: Resultsmentioning

confidence: 99%

Interpreting the near-infrared reflectance of a series of perylene pigments

2013

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“…The integration of multiresponse to multi-species by a single probe can demonstrate the redox homeostasis process more clearly. [32][33][34][35][36][37][38][39] Moreover, the multiresponse probes can benefit from inaccurate calibration. And they can also avoid potobleaching rates of individual probes, uneven probe loading, nonhomogeneous distribution uncontrollable localization, larger invasive effects, metabolisms, and interference of spectral overlap.…”

Section: Introductionmentioning

confidence: 99%

Near-Infrared Fluorescence Probe for in Situ Detection of Superoxide Anion and Hydrogen Polysulfides in Mitochondrial Oxidative Stress

et al. 2016

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H 2 S plays important physiological and pathological roles in cardiovascular system and nervous system. But recent evidences imply that hydrogen polysulfides (H 2 S n ) are the actual signaling molecules in cells. Although H 2 S n have been demonstrated to be responsible for mediating tumor suppressors, ion channels, and transcription factors, more of their biological effects are still need to be elaborated. On one hand, H 2 S n have been suggested to be generated from endogenous H 2 S upon reaction with reactive oxygen species (ROS). On the other hand, H 2 S n derivatives are proposed to be a kind of direct antioxidant against intracellular oxidative stress. This conflicting results should be attributed to the regulation of redox homeostasis between ROS and H 2 S n . Superoxide anion (O 2 •− ) is undoubtedly the primary ROS existing in mitochondria. We reason that the balance of O 2•− and H 2 S n are pivotal in physiological and pathological processes. Herein, we report two near-infrared fluorescent probes Hcy-Mito and Hcy-Biot for the detection of O 2•− and H 2 S n in cells and in vivo. Hcy-Mito is conceived to be applied in mitochondria, and Hcy-Biot is designed to target tumor tissue. Both of the probes were successfully applied for visualizing exogenous and endogenous O 2•− and H 2 S n in living cells and in tumor mice models. The results demonstrate that H 2 S n can be promptly produced by mitochondrial oxidative stress. Flow cytometry assays for apoptosis suggest that H 2 S n play critical roles in antioxidant systems.

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“…14 In addition, it is essential to introduce a fast excited state process to modulate the fluorescence of selenide and selenoxide. In our previous studies, 15 we have utilized photoinduced electron transfer (PET) and developed a reversible probe based on selenide and selenoxide successfully. In this study, we selected 1,8-naphthalimide as a signal transducer and designed a reversible fluorescent probe (NI-Se, Fig.…”

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A reversible fluorescent probe for detecting hypochloric acid in living cells and animals: utilizing a novel strategy for effectively modulating the fluorescence of selenide and selenoxide

et al. 2013

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Based on a novel strategy for modulating the fluorescence of selenide and selenoxide, we have designed and developed a reversible fluorescent probe for hypochloric acid. And the synthesis, characterization, fluorescence properties, as well as the biological applications in living cells and animals, have all been described. † Electronic supplementary information (ESI) available: Additional fluorescent confocal images, fluorescence spectra assays, TDDFT calculations, details of the synthesis, 1 H NMR, 13 C NMR, 77 Se NMR, MS spectra of compounds discussed in this communication. See

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A Near-IR Reversible Fluorescent Probe Modulated by Selenium for Monitoring Peroxynitrite and Imaging in Living Cells

Cited by 538 publications

References 38 publications

Interpreting the near-infrared reflectance of a series of perylene pigments

Interpreting the near-infrared reflectance of a series of perylene pigments

Near-Infrared Fluorescence Probe for in Situ Detection of Superoxide Anion and Hydrogen Polysulfides in Mitochondrial Oxidative Stress

A reversible fluorescent probe for detecting hypochloric acid in living cells and animals: utilizing a novel strategy for effectively modulating the fluorescence of selenide and selenoxide

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