A narrative overview of utilizing biomaterials to recapitulate the salient regenerative features of dental-derived mesenchymal stem cells

Ansari, Sahar; Sevari, Sevda Pouraghaei

doi:10.1038/s41368-021-00126-4

Cited by 14 publications

(5 citation statements)

References 180 publications

(137 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Biomaterial-based platforms can be engineered to provide spatial and temporal control over autophagic processes, promoting tissue regeneration or selectively targeting autophagy in diseased cells. These advances pave the way for personalized medicine approaches, tailoring autophagy modulation strategies to individual patient needs [ 201 ]. In the field of cancer therapy, biomaterials offer exciting prospects for autophagy modulation.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Autophagy and Biomaterials: A Brief Overview of the Impact of Autophagy in Biomaterial Applications

Pirmoradi,

Shojaei,

Ghavami

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

Macroautophagy (hereafter autophagy), a tightly regulated physiological process that obliterates dysfunctional and damaged organelles and proteins, has a crucial role when biomaterials are applied for various purposes, including diagnosis, treatment, tissue engineering, and targeted drug delivery. The unparalleled physiochemical properties of nanomaterials make them a key component of medical strategies in different areas, such as osteogenesis, angiogenesis, neurodegenerative disease treatment, and cancer therapy. The application of implants and their modulatory effects on autophagy have been known in recent years. However, more studies are necessary to clarify the interactions and all the involved mechanisms. The advantages and disadvantages of nanomaterial-mediated autophagy need serious attention in both the biological and bioengineering fields. In this mini-review, the role of autophagy after biomaterial exploitation and the possible related mechanisms are explored.

show abstract

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Autophagy and Biomaterials: A Brief Overview of the Impact of Autophagy in Biomaterial Applications

Pirmoradi,

Shojaei,

Ghavami

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…Biomaterials are one of the essential components in making scaffolds. By combining scaffolds with different stem cells, tissue bioengineering offers promising results in regenerating damaged tissues [ 152 ].…”

Section: Biomaterials and Scaffolds Used With Dscsmentioning

confidence: 99%

Stem cells and common biomaterials in dentistry: a review study

Mosaddad

Rasoolzade

Namanloo

et al. 2022

J Mater Sci: Mater Med

View full text Add to dashboard Cite

Stem cells exist as normal cells in embryonic and adult tissues. In recent years, scientists have spared efforts to determine the role of stem cells in treating many diseases. Stem cells can self-regenerate and transform into some somatic cells. They would also have a special position in the future in various clinical fields, drug discovery, and other scientific research. Accordingly, the detection of safe and low-cost methods to obtain such cells is one of the main objectives of research. Jaw, face, and mouth tissues are the rich sources of stem cells, which more accessible than other stem cells, so stem cell and tissue engineering treatments in dentistry have received much clinical attention in recent years. This review study examines three essential elements of tissue engineering in dentistry and clinical practice, including stem cells derived from the intra- and extra-oral sources, growth factors, and scaffolds.

show abstract

“…Numerous ECM analogs have been developed that mimic the physiological 3D microenvironment to support cellular function, including synthetic scaffolds derived from polymeric substrates and natural biopolymers [13,14]. Although these ECM analogs have been extensively studied for applications in tissue engineering, they lack the complex biochemical properties and three-dimensional structure of the native ECM.…”

Section: Introductionmentioning

confidence: 99%

Influence of Extracellular Matrix Components on the Differentiation of Periodontal Ligament Stem Cells in Collagen I Hydrogel

Ivanov,

Kuznetsova,

Popova

et al. 2023

Cells

View full text Add to dashboard Cite

Regeneration of periodontal tissues requires an integrated approach to the restoration of the periodontal ligament, cementum, and alveolar bone surrounding the teeth. Current strategies in endogenous regenerative dentistry widely use biomaterials, in particular the decellularized extracellular matrix (dECM), to facilitate the recruitment of populations of resident cells into damaged tissues and stimulate their proliferation and differentiation. The purpose of our study was to evaluate the effect of the exogenous components of the extracellular matrix (hyaluronic acid, laminin, fibronectin) on the differentiation of periodontal ligament stem cells (PDLSCs) cultured with dECM (combinations of decellularized tooth matrices and periodontal ligament) in a 3D collagen I hydrogel. The immunohistochemical expression of various markers in PDLSCs was assessed quantitatively and semi-quantitatively on paraffin sections. The results showed that PDLSCs cultured under these conditions for 14 days exhibited phenotypic characteristics consistent with osteoblast-like and odontoblast-like cells. This potential has been demonstrated by the expression of osteogenic differentiation markers (OC, OPN, ALP) and odontogenic markers (DSPP). This phenomenon corresponds to the in vivo state of the periodontal ligament, in which cells at the interface between bone and cementum tend to differentiate into osteoblasts or cementoblasts. The addition of fibronectin to the dECM most effectively induces the differentiation of PDLSCs into osteoblast-like and odontoblast-like cells under 3D culture conditions. Therefore, this bioengineered construct has a high potential for future use in periodontal tissue regeneration.

show abstract

A narrative overview of utilizing biomaterials to recapitulate the salient regenerative features of dental-derived mesenchymal stem cells

Cited by 14 publications

References 180 publications

Autophagy and Biomaterials: A Brief Overview of the Impact of Autophagy in Biomaterial Applications

Autophagy and Biomaterials: A Brief Overview of the Impact of Autophagy in Biomaterial Applications

Stem cells and common biomaterials in dentistry: a review study

Influence of Extracellular Matrix Components on the Differentiation of Periodontal Ligament Stem Cells in Collagen I Hydrogel

Contact Info

Product

Resources

About