A NaHCO<sub>3</sub> Promoted Three‐component Cyclization: Easy Access to Benzodisulfide Heterocycles

An easy two‐/three‐component selective thioetherification of KSAc for the synthesis of a series of symmetrical/unsymmetrical 4‐alkylthio‐3‐halo‐2(5H)‐furanones has been described. The reaction without any metal catalyst or additive is carried out in air atmosphere at room temperature for 5 h, only using potassium thioacetate as an odourless sulfur source and a base simultaneously. The broad substrate scope and high yield make it important for the studies on both constructing C−S bond based on non‐aryl Csp2−X bond and synthesizing new 2(5H)‐furanone functional molecules.

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Multicomponent Selective Thioetherification of KSAc: Easy Access to Symmetrical/Unsymmetrical 4‐Alkylthio‐3‐halo‐2(5H)‐furanones

Zhou

Fang

Yang

et al. 2023

Asian J Org Chem

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Synthesis of (E)‐β‐Iodovinyl Sulfones via HI‐mediated Vicinal Iodosulfonylation of Alkynes with Sodium Sulfinates

Chen,

Zeng,

et al. 2024

Asian J Org Chem

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Iodine-Promoted Disproportionate Coupling Reaction of Arylsulfonyl Hydrazides: A Simple and Green Access to Thiosulfonates

Chen,

et al. 2024

Synthesis

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An environmentally friendly iodine-promoted disproportionate coupling reaction of aryl sulfonyl hydrazides has been proposed. This strategy can synthesize thiosulfonate with medium to excellent yield, and features a green system, wide applicability of substrate and easy availability of raw materials. The preliminary mechanistic study reveals that iodine plays an important role in the radical reaction process.

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A NaHCO₃ Promoted Three‐component Cyclization: Easy Access to Benzodisulfide Heterocycles

Cited by 4 publications

References 47 publications

Multicomponent Selective Thioetherification of KSAc: Easy Access to Symmetrical/Unsymmetrical 4‐Alkylthio‐3‐halo‐2(5H)‐furanones

Multicomponent Selective Thioetherification of KSAc: Easy Access to Symmetrical/Unsymmetrical 4‐Alkylthio‐3‐halo‐2(5H)‐furanones

Synthesis of (E)‐β‐Iodovinyl Sulfones via HI‐mediated Vicinal Iodosulfonylation of Alkynes with Sodium Sulfinates

Iodine-Promoted Disproportionate Coupling Reaction of Arylsulfonyl Hydrazides: A Simple and Green Access to Thiosulfonates

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A NaHCO3 Promoted Three‐component Cyclization: Easy Access to Benzodisulfide Heterocycles

Cited by 4 publications

References 47 publications

Multicomponent Selective Thioetherification of KSAc: Easy Access to Symmetrical/Unsymmetrical 4‐Alkylthio‐3‐halo‐2(5H)‐furanones

Multicomponent Selective Thioetherification of KSAc: Easy Access to Symmetrical/Unsymmetrical 4‐Alkylthio‐3‐halo‐2(5H)‐furanones

Synthesis of (E)‐β‐Iodovinyl Sulfones via HI‐mediated Vicinal Iodosulfonylation of Alkynes with Sodium Sulfinates

Iodine-Promoted Disproportionate Coupling Reaction of Arylsulfonyl Hydrazides: A Simple and Green Access to Thiosulfonates

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Product

Resources

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A NaHCO₃ Promoted Three‐component Cyclization: Easy Access to Benzodisulfide Heterocycles