Multicomponent Selective Thioetherification of KSAc: Easy Access to Symmetrical/Unsymmetrical 4‐Alkylthio‐3‐halo‐2(5H)‐furanones

Abstract

An easy two‐/three‐component selective thioetherification of KSAc for the synthesis of a series of symmetrical/unsymmetrical 4‐alkylthio‐3‐halo‐2(5H)‐furanones has been described. The reaction without any metal catalyst or additive is carried out in air atmosphere at room temperature for 5 h, only using potassium thioacetate as an odourless sulfur source and a base simultaneously. The broad substrate scope and high yield make it important for the studies on both constructing C−S bond based on non‐aryl Csp2−X bond and synthesizing new 2(5H)‐furanone functional molecules.

DBDMH-Promoted Methylthiolation in DMSO: A Metal-Free Protocol to Methyl Sulfur Compounds with Multifunctional Groups

“…Thus, herein, on the basis of our group's previous research on various functionalization reactions of 3,4-dihalo-2(5H)-furanones for bioactive compounds [50,51], we developed a simple, mild and transition metal-free method to realize the greener methyl-Scheme 2. Green synthesis from 3,4-dihalo-2(5H)-furanone and various sulfur-containing reagents [32,40,41,43].…”

“…Thus, herein, on the basis of our group's previous research on various functionalization reactions of 3,4-dihalo-2(5H)-furanones for bioactive compounds [50,51], we developed a simple, mild and transition metal-free method to realize the greener methylthiolation of 3,4-dihalo-2(5H)-furanones by further optimizing the conditions of the methylthiolation reaction from 3,4-dihalo-2(5H)-furanone and DMSO (Scheme 2, this work).…”