A Multivariate Analysis of Risk Factors for Pneumonia Following Cardiac Transplantation

Mj, Corensek; Rw, Stewart; Tf, Keys; Ac, Mehta; Mc, McHenry; Goormastic, M.

doi:10.1097/00007890-198812000-00014

Cited by 23 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4,13,14 In the present study, we did not observe cytomegalovirus infection in our heart transplant recipients, most probably due to our effective prophylaxis regimen.…”

Section: Discussioncontrasting

confidence: 39%

“…In this study, there were 3.6 deaths due to pulmonary infections per 100 heart transplant recipients; 3.3%, 6%, and 7.6% patients died in other recent series. 3,4,14 The overall mortality in heart transplant recipients with pneumonia is from 23% to 25% (23% in our study); this rate varies widely depending on the cause. 3,4,14 Aspergillus pneumonia has the worst prognosis.…”

Section: Discussionmentioning

confidence: 60%

“…3,4,14 The overall mortality in heart transplant recipients with pneumonia is from 23% to 25% (23% in our study); this rate varies widely depending on the cause. 3,4,14 Aspergillus pneumonia has the worst prognosis. The mortality rate associated with this pulmonary infection was 50% in a review involving 64 patients.…”

Section: Discussionmentioning

confidence: 60%

“…12 Pulmonary infections in heart transplant recipients frequently are polymicrobial (24%-58%) in other studies. 4,13,14 Aspergillus species were the most common cause of pulmonary infections in our population (23% isolates). The incidence of Aspergillus pneumonia was 3.6 cases per 100 heart transplants, similar to the incidence reported in recent studies.…”

Section: Discussionmentioning

confidence: 85%

“…The incidence of Aspergillus pneumonia was 3.6 cases per 100 heart transplants, similar to the incidence reported in recent studies. 3,14,15 The changes in immunosuppressive treatment and the degree of environmental exposure, which are the main risk factors for the development of pulmonary aspergillosis, could explain the occurrence of Aspergillus infection.…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Long-Term Pulmonary Infections in Heart Transplant Recipients

Küpeli̇

Ulubay²,

Es³

et al. 2015

Exp Clin Transplant

View full text Add to dashboard Cite

Objectives: Pulmonary infections are life-threatening complications in heart transplant recipients. Our aim was to evaluate long-term pulmonary infections and the effect of prophylactic antimicrobial strategies on time of occurrence of pulmonary infections in heart transplant recipients. Materials and Methods:Patients who underwent heart transplantation between 2003 and 2013 at Baskent University were reviewed. Demographic information and data about immunosuppression and infectious episodes were collected. Results: In 82 heart transplant recipients (mean age, 33.85 y; 58 male and 24 female), 13 recipients (15.8%) developed pulmonary infections (mean age, 44.3 y; 9 male and 4 female). There were 12 patients who had dilated cardiomyopathy and 1 patient who had myocarditis before heart transplantation; 12 patients received immunosuppressive therapy in single or combination form. Pulmonary infections developed in the first month (1 patient), from first to third month (6 patients), from third to sixth month (1 patient), and > 6 months after transplantation (5 patients). Chest computed tomography showed consolidation (unilateral, 9 patients; bilateral, 4 patients). Multiple nodular consolidations were observed in 2 patients and a cavitary lesion was detected in 1 patient. Bronchoscopy was performed in 6 patients; 3 patients had Aspergillus fumigatus growth in bronchoalveolar lavage fluid, and 2 patients had Acinetobacter baumannii growth in sputum. Treatment was empiric antibiotics (6 patients), antifungal drugs (5 patients), and both antibiotics and antifungal drugs (2 patients); treatment period was 1-12 months in patients with invasive pulmonary aspergillosis. Conclusions: Pulmonary infections are the most common cause of mortality in heart transplant recipients. A. fumigatus is the most common opportunistic pathogen. Heart transplant recipients with fever and cough should be evaluated for pulmonary infections, and invasive pulmonary aspergillosis should be suspected if these symptoms occur within the first 3 months. Immediately starting an empiric antibiotic is important in treating pulmonary infections in heart transplant recipients.

show abstract

“…4,13,14 In the present study, we did not observe cytomegalovirus infection in our heart transplant recipients, most probably due to our effective prophylaxis regimen.…”

Section: Discussioncontrasting

confidence: 39%