A multifunctional extract from corn steep liquor: antioxidant and surfactant activities

Colloids and Surfaces B: Biointerfaces

Shokry

Cruz

et al. 2019

The permeation of ten model drugs through silicone membrane was analysed to investigate the effect of the presence of a biosurfactant obtained from corn steep liquor. The ten selected pharmaceutical compounds were chosen to include a diverse range of physicochemical properties, such as variable hydrophobicities, pKa's, molecular masses and degrees of ionisation. When compared with compound permeation alone, the additional inclusion of biosurfactant in the donor phase altered the rate and extent of permeation. It significantly enhanced permeation for five of the compounds, whereas it decreased permeation for four of the compounds and remained approximately the same for the tenth compound. These effects were observed at both biosurfactant concentrations considered, namely 0.005 mg/mL, i.e. below the critical micellar concentration (CMC) and 0.500 mg/mL, i.e. above the CMC of the biosurfactant. Upon analysing permeation change with respect to physicochemical properties of the compounds, it was determined that compounds with a relative molecular mass below 200 resulted in an increase in permeation with biosurfactant present, and those above 200 resulted in a decrease in permeation with biosurfactant present. This effect was therefore attributed to the formation of a drug-biosurfactant interaction that enhanced permeation of smaller compounds, yet retarded permeation for those with a higher molecular mass. These in vitro findings can be considered an indication of potential novel formulation options that incorporate biosurfactant to create transdermal products that have bespoke permeation profiles.

Section: Characterisation Of Biosurfactant Extractsupporting

confidence: 86%

The effect of the presence of biosurfactant on the permeation of pharmaceutical compounds through silicone membrane

Colloids and Surfaces B: Biointerfaces

Shokry

Cruz

et al. 2019

“…In previous studies it has been demonstrated the presence of biosurfactants in CSW (Rodríguez-López et al, 2016;Vecino et al, 2014Vecino et al, , 2015a. This industrial stream is characterized by a high viscosity (it contains 50% of solids), low concentration of sugars and high concentration of lactic acid, which has been employed by many researchers as nutritional supplement in the production of microbial metabolites (Guerra-Rodríguez & Vázquez, 2013).…”

Section: Resultsmentioning

confidence: 99%

“…Regarding the composition of the biosurfactant extracted from CSW, it was characterized as a lipopeptide, composed by C16 and C18 fatty acids, comprising oleic, linoleic and stearic fatty acids which are linked to a small fraction of an organic nitrogen chain composed by amino acids (Rincón-Fontan, Rodríguez-López, Rodríguez-López, Vecino, Barbosa-Pereira, Moldes, & Cruz, 2016;Vecino, Rodríguez-López, Cruz, & Moldes, 2015b). Therefore, Rincón-Fontán et al (2017) reported that this biosurfactant possesses a molecular weight similar to the lipopeptides produced by B.subtillis.…”

Section: Introductionmentioning

confidence: 99%

Isolation and characterization of a microorganism that produces biosurfactants in corn steep water

López-Prieto

Martínez-Padrón

et al. 2019

CyTA - Journal of Food

In this work a Bacillus strain with capacity to produce biosurfactants was isolated from commercial corn steep water (CSW). The identification of this bacterium was based on phenotypic characteristics. This is a Gram-positive Bacillus, macroscopically catalase-negative, that possesses high mobility and forms terminal endospore. The colonies formed by the isolated Bacillus strain are characterized by a creaming, dull and glistening phenotype with a small point-like elevation in the center. Regarding its antimicrobial activity, the isolated Bacillus strain was effective against Candida albicans and Staphylococcus aureus observing, in the presence of pathogenic strains, a phenotype dissociation, switching the colonies from a whitish to yellowish pigmentation. The isolated microorganism, contrarily to other Bacillus strains, has the ability to produce extracellular and cell-bound biosurfactants. The analyses revealed that both biosurfactant extracts are similar to the lipopeptide biosurfactant produced by Bacillus subtilis. Aislamiento y caracterización del microorganismo responsable de la producción de biosurfactantes en licores de lavado de maíz RESUMEN ARTICLE HISTORY

“…Furthermore, the fatty acids profile of the biosurfactant extracts was analyzed by GC-MS-MS (gas chromatography coupled to a mass spectrometer) on a Model Scion 451 GC (Bruker) equipped with a PTV 1019 universal capillary injector, coupled to a mass spectrometer, controlled by System Control software. Prior to analysis, the biosurfactant extracts were submitted to a derivatization process following the procedure described by Rodríguez-López et al [36]. Afterwards, 1 mL of sample was injected using a splitless mode.…”

Section: C) Fatty Acid Composition Determined By Gc-ms-msmentioning

confidence: 99%

Vineyard pruning waste as an alternative carbon source to produce novel biosurfactants by Lactobacillus paracasei

Vecino

Journal of Industrial and Engineering Chemistry

Gudiña

et al. 2017

Self Cite

Cellulosic sugars extracted from vineyard pruning waste (VPW) were used as a low-cost carbon source for biosurfactant production by Lactobacillus paracasei. The results obtained showed that when glucose from VPW was used, the biosurfactant was a glycolipopeptide, whereas when it was replaced by lactose the biosurfactant produced was a glycoprotein. Additionally, it was found that the extraction process, either with phosphate-buffer or phosphate-buffer saline, influenced the biosurfactant chemical structure and emulsion capacity. Overall, these results highlight the possibility of producing biosurfactants "à la carte" with the same strain but changing the carbon source, increasing its potential in different industrial applications.