A multicenter, randomized, double-blind comparison of the efficacy and safety of irbesartan and enalapril in adults with mild to moderate essential hypertension, as assessed by ambulatory blood pressure monitoring: The MAPAVEL study

Coca, António; Calvo, Carlos; García-Puig, Juan; Gil‐Extremera, Blas; Aguilera, Mònica; Sierra, Alejandro de la; Martín-Hidalgo, Alberto; Marín, Rafael

doi:10.1016/s0149-2918(02)85010-x

Cited by 36 publications

(26 citation statements)

References 25 publications

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“…Seventeen studies described in 19 papers (33,45,51,58,60,72,76,79,80,83,(87)(88)(89)(90)(91)(92)(93)(94)(95) reported quantitative information on persistence or adherence. We operationally defined adherence as the consistency with which medica- The first group is observational studies and the second group is randomized, controlled trials.…”

Section: Adherence and Persistencementioning

confidence: 99%

Systematic Review: Comparative Effectiveness of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers for Treating Essential Hypertension

et al. 2008

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Section: Adherence and Persistencementioning

confidence: 99%

Systematic Review: Comparative Effectiveness of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers for Treating Essential Hypertension

et al. 2008

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“…ARBs and ACE inhibitors have been shown to be beneficial in patients with hypertension, myocardial infarction, diabetes mellitus and/or renal disease or chronic heart failure ( Table 1). The results of clinical trials and meta-analyses indicate that ARBs are as effective as ACE inhibitors in patients with hypertension [46][47][48][49][50][51][52][53][54][55][56][57][58][59], chronic heart failure [60] (although there was a trend towards a lower incidence of sudden death and resuscitated arrests with captopril vs losartan in the ELITE II trial) [26,60], or acute myocardial infarction [32,34]. However, while ACE inhibitors have been shown to be effective in the secondary prevention of coronary disease in patients with stable coronary artery disease and/or high cardiovascular risk (e.g.…”

Section: Methods Of Raas Blockade: Arbs and Ace Inhibitorsmentioning

confidence: 99%

Efficacy of Angiotensin Receptor Blockers in Cardiovascular Disease

Maggioni

2006

Cardiovasc Drugs Ther

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The cardiovascular continuum describes the progression of pathophysiologic events from cardiovascular risk factors to symptomatic cardiovascular disease (CVD) and life-threatening events. Pharmacologic intervention early in the continuum may prevent or slow CVD development and improve quality of life. The renin-angiotensin-aldosterone system (RAAS) is central to the pathophysiology of CVD at many stages of the continuum. Numerous clinical trials of angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) have shown that RAAS blockade provides benefits to patients across the continuum. ARBs are as effective as ACE inhibitors in the treatment of hypertension; however tolerability and adherence to therapy appear to be improved with ARBs. Large clinical trials have shown that ARBs may provide therapeutic benefits beyond blood pressure control in patients with diabetes, heart failure or at risk of heart failure following a myocardial infarction. In addition, ARBs have been shown to provide protective effects in patients with impaired renal function or left ventricular hypertrophy. Additional clinical trials are ongoing to further characterize the role of ARBs in CVD management.

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“…[1]. Многочисленные ис-следования подтвердили высокую антигипертензивную эффективность БРА, не уступающую таковой у иАПФ [2][3][4][5][6]. Но при этом БРА отличаются более высоким уров-нем безопасности по сравнению с иАПФ, т.к.…”

Section: рациональная фармакотерапия в кардиологии 2012;8(1) сравнитеunclassified

The Comparative Study of Efficacy and Tolerability of Generic and Original Valsartan as a Monotherapy or in Combination With Hydrochlorothiazide and Bisoprolol in Patients With Arterial Hypertension of 1-2 Degree and Metabolic Syndrome

Martsevich

Lukina

Дмитриева

et al. 2012

Racionalʹnaâ farmakoterapiâ v kardiologii

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A multicenter, randomized, double-blind comparison of the efficacy and safety of irbesartan and enalapril in adults with mild to moderate essential hypertension, as assessed by ambulatory blood pressure monitoring: The MAPAVEL study

Cited by 36 publications

References 25 publications

Systematic Review: Comparative Effectiveness of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers for Treating Essential Hypertension

Systematic Review: Comparative Effectiveness of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers for Treating Essential Hypertension

Efficacy of Angiotensin Receptor Blockers in Cardiovascular Disease

The Comparative Study of Efficacy and Tolerability of Generic and Original Valsartan as a Monotherapy or in Combination With Hydrochlorothiazide and Bisoprolol in Patients With Arterial Hypertension of 1-2 Degree and Metabolic Syndrome

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