A multi-walled carbon nanotubes based molecularly imprinted polymers electrochemical sensor for the sensitive determination of HIV-p24

Ma, Yu; Shen, Xiaolei; Zeng, Qiang; Wang, Haishui; Wang, Lishi

doi:10.1016/j.talanta.2016.11.043

Cited by 104 publications

(59 citation statements)

References 37 publications

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“…HIV is a member of retroviruses, it is disseminated mainly by contaminated blood transfusions, unprotected sex, and others. Ma et al [64] developed an electrochemical biosensor based on multi-walled carbon nanotubes modified MIPs for the detection of HIV-p24. They proved that MIPs have a specific recognition capacity for HIV-p24.…”

Section: Detection Of Infectious Diseases Caused By Virusesmentioning

confidence: 99%

Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases

Cui

Zhou

2020

Sensors

137

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Owing to their merits of simple, fast, sensitive, and low cost, electrochemical biosensors have been widely used for the diagnosis of infectious diseases. As a critical element, the receptor determines the selectivity, stability, and accuracy of the electrochemical biosensors. Molecularly imprinted polymers (MIPs) and surface imprinted polymers (SIPs) have great potential to be robust artificial receptors. Therefore, extensive studies have been reported to develop MIPs/SIPs for the detection of infectious diseases with high selectivity and reliability. In this review, we discuss mechanisms of recognition events between imprinted polymers with different biomarkers, such as signaling molecules, microbial toxins, viruses, and bacterial and fungal cells. Then, various preparation methods of MIPs/SIPs for electrochemical biosensors are summarized. Especially, the methods of electropolymerization and micro-contact imprinting are emphasized. Furthermore, applications of MIPs/SIPs based electrochemical biosensors for infectious disease detection are highlighted. At last, challenges and perspectives are discussed.

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Section: Detection Of Infectious Diseases Caused By Virusesmentioning

confidence: 99%

Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases

Cui

Zhou

2020

Sensors

137

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“…Great effort has also been directed towards the development of electrochemical devices capable of early detection of immune deficiency diseases, such as acquired immune deficiency syndrome (AIDS) caused by the HIV-retrovirus. Ma et al [42] proposed a device composed by a GCE modified with MWCNT and molecularly imprinted polymers (MIPs) based on CTS for the determination of HIV-p24 protein in real human serum samples ( Figure 6). Using DPV and the developed sensor (HIV-p24/CTS/MWCNT/GCE), a low limit of detection (0.083 pg cm −3 ), good selectivity, repeatability, reproducibility, stability, and accuracy were reached for the proposed electroanalysis; validation was performed by comparative studies with enzyme-linked immunosorbent assay (ELISA).…”

Section: Overview Of Mwcnt Applications In Electrochemical Sensorsmentioning

confidence: 99%

“…Figure 6. Detailed procedure diagram for fabrication of the HIV-p24/CTS/MWCNT/GCE sensor (adapted by permission from Reference [42]).…”

Section: Overview Of Mwcnt Applications In Electrochemical Sensorsmentioning

confidence: 99%

New Generation of Electrochemical Sensors Based on Multi-Walled Carbon Nanotubes

Oliveira

Morais

2018

Applied Sciences

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Multi-walled carbon nanotubes (MWCNT) have provided unprecedented advances in the design of electrochemical sensors. They are composed by sp2 carbon units oriented as multiple concentric tubes of rolled-up graphene, and present remarkable active surface area, chemical inertness, high strength, and low charge-transfer resistance in both aqueous and non-aqueous solutions. MWCNT are very versatile and have been boosting the development of a new generation of electrochemical sensors with application in medicine, pharmacology, food industry, forensic chemistry, and environmental fields. This work highlights the most important synthesis methods and relevant electrochemical properties of MWCNT for the construction of electrochemical sensors, and the numerous configurations and successful applications of these devices. Thousands of studies have been attesting to the exceptional electroanalytical performance of these devices, but there are still questions in MWCNT electrochemistry that deserve more investigation, aiming to provide new outlooks and advances in this field. Additionally, MWCNT-based sensors should be further explored for real industrial applications including for on-line quality control.

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“…23,24 Concerning the last approach, a cross-linking method through chitosan and glutaraldehyde on gold-free carbon electrode substrates has been recently investigated. 17,25 CS is a linear polysaccharide composed of randomly distributed b-(1,4)-linked D-glucosamine and N-acetyl-D-glucosamine; its peculiar feature is the presence of a primary amino group at C-2 position of the glucose-amine residues, which can be suited to bind the receptor. Specically, CS is chemisorbed on carbon substrates, whereas GA is used as cross-linker for covalent binding of bio-receptors.…”

Section: Immobilization Of P24 Antigen On Gold-free Swcnt-spcesmentioning

confidence: 99%

Innovative gold-free carbon nanotube/chitosan-based competitive immunosensor for determination of HIV-related p24 capsid protein in serum

et al. 2017

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A multi-walled carbon nanotubes based molecularly imprinted polymers electrochemical sensor for the sensitive determination of HIV-p24

Cited by 104 publications

References 37 publications

Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases

Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases

New Generation of Electrochemical Sensors Based on Multi-Walled Carbon Nanotubes

Innovative gold-free carbon nanotube/chitosan-based competitive immunosensor for determination of HIV-related p24 capsid protein in serum

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