Water resources utilization, social economy development, and ecological environment protection are key factors in regional sustainable development. Scientific evaluation of regional coordinated development status and diagnosis of regional uncoordinated development constraints will improve the management level of decision-makers. At present, most developing countries have the problem of unbalanced regional development caused by the one-sided pursuit of a certain system. Taking 14 prefecture-level cities in Hunan Province as cases, this paper analyzed the spatial and temporal distribution characteristics of the carrying capacity level of the water resources system, the development level of the social economy system and the protection level of the ecological environment system in each evaluation unit based on entropy weight method and order parameter analysis. Based on the theory of coordinated development, a calculation model of a coordinated development degree was constructed, and the corresponding evaluation criteria were formulated. The spatial and temporal distribution characteristics of a coordinated development degree in each research unit were analyzed and evaluated. The results showed that the average coordinated development degree of Hunan Province from 2004 to 2016 evolved from “Light disorder recession” to “Nearly disorder recession”, then to “Reluctance coordinated development”. Restricted by different systems, the coordinated development degree in each research unit presented spatial and temporal differences. According to different development stages and the characteristics of different regions, corresponding development strategies can be formulated to provide the guidance for coordinated the development of regions.