A multi-institutional retrospective analysis of external radiotherapy for mucosal melanoma of the head and neck in Northern Japan

Wada, Hitoshi; Nemoto, Kenji; Ogawa, Yoshihiro; Hareyama, Masato; Yoshida, Hiroshi; Takamura, Akira; Ohmori, Keiichi; Hamamoto, Yasushi; Sugita, Tadashi; Saitoh, Mari; Yamada, Satoshi

doi:10.1016/j.ijrobp.2003.11.013

Cited by 99 publications

(83 citation statements)

References 17 publications

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“…Furthermore, the optimal total dose of radiation and the distribution plan are yet to be determined (11). A previous study found that a high dose (>54 Gy) of irradiation improved the local control rate of tumors and led to a lower recurrence rate (12). However, Krengli et al (13) indicated that large doses of radiotherapy had no clear effect on tumor control or the 5-year survival rate of patients.…”

Section: Discussionmentioning

confidence: 99%

Clinical analysis of 29 cases of nasal mucosal malignant melanoma

Liu

2015

Oncology Letters

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Abstract. The present study aimed to investigate the clinical features of nasal mucosa malignant melanoma, including the histopathological features and factors affecting prognosis. A retrospective analysis of the clinical data obtained from the Department of Otolaryngology Head and Neck Surgery, Tianjin Huanhu Hospital (Tianjin, China) between October 1999 and June 2013 was performed using the Kaplan-Meier method. In total, 29 cases of nasal mucosal malignant melanoma were analyzed. The overall 3-and 5-year survival rates were 48.3 and 27.6%, respectively. The study group consisted of 18 males and 11 females, with a median age of 61.5 years. Overall, 19 patients underwent surgery, 28 received radiotherapy and 17 received chemotherapy. The American Joint Committee on Cancer staging system (AJCC) was used to retrospectively stage the tumors. In total, 8 were tumor stage (T)1, 10 were T2, 6 were T3 and 5 were T4. The results revealed that the T stage, surgical treatment, location of the tumor and the presence of black pigmentation affected the 5-year survival rate of the patients. By contrast, radiotherapy and chemotherapy had no effect on the overall survival rate. Overall, endoscopic or endoscopic-assisted surgery were the preferred methods of treatment, and histological features, including the presence of tumor melanin pigmentation, affected the prognosis of the patients. This study indicated that the AJCC staging system is able to effectively predict the prognosis of patients with nasal mucosa malignant melanoma.

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Section: Discussionmentioning

confidence: 99%

Clinical analysis of 29 cases of nasal mucosal malignant melanoma

Liu

2015

Oncology Letters

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“…Local control of 49% at 3 years was observed in these patients (31). A similar report on 31 patients from multiple institutions treated with definitive RT showed a local control of 58.1% (33). The authors also noted that there was an increase in the local control and survival in patients who received a hypofractionated regimen with a dose per fraction greater than 3 Gy (33).…”

Section: Rt In Mucosal Melanomasmentioning

confidence: 53%

“…A similar report on 31 patients from multiple institutions treated with definitive RT showed a local control of 58.1% (33). The authors also noted that there was an increase in the local control and survival in patients who received a hypofractionated regimen with a dose per fraction greater than 3 Gy (33). Based on these findings, patients with unresectable mucosal melanoma, primary RT should be attempted for patients with localized disease.…”

Section: Rt In Mucosal Melanomasmentioning

confidence: 70%

“…The local recurrence rates with adjuvant radiation ranges from 15 to 30% (27)(28)(29). Despite the local control benefit of adjuvant radiation, there is no impact on overall survival, likely due to the high risk of systemic relapse (28)(29)(30)(31)(32)(33). Many patients present with unresectable lesions due to location and proximity to critical structures, particularly in the head and neck.…”

Section: Rt In Mucosal Melanomasmentioning

confidence: 99%

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Radiation Therapy for Melanoma

Shi

2017

Cutaneous Melanoma: Etiology and Therapy

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Although melanoma is a relative radioresistant tumor, radiation therapy (RT) remains a valid and effective treatment option for the management of melanoma. RT as a primary treatment is often offered in well-defined situations, such as medical inoperability, lentiginous melanoma, mucosal melanoma, and ocular melanoma. Adjuvant RT following lymphadenectomy in node-positive melanoma patients prevents local and regional recurrence; however, the role of adjuvant RT remains controversial and underutilized due to lack of overall survival benefit. On the other hand, RT is highly effective in providing symptom palliation for metastatic melanoma and is widely used. Advanced RT technologies such as stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT) can achieve excellent local control with minimum toxicities. They are commonly used in the management of brain, lung, spine, and liver metastases. Most recently, it is under active investigation on combining RT with new systemic options, such as targeted therapy, or immunotherapy. The advancements in the treatment of patients with melanoma highlight the importance of multidisciplinary management in this disease. Radiation therapy will continue to be one of the key therapeutic options.

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“…La radiothérapie post chirurgie semble donner un meilleur contrôle local et améliore la survie (4). Pour Wada, la radiothérapie post opératoire nʼa pas donné dʼeffet sur les gros résidus tumoraux (12). Lʼutilisation de la chimiothérapie pour les mélanomes muqueux à base de Déticène, Dacarbazine ou le Cis-platinum (3, 7, 10, 11) nʼa prouvé son efficacité devant les mélanomes malins quelque soit sa localisation (3,4).…”

Section: Discussionunclassified

Localisation rare du melanome muqueux

Hammami¹,

Moalla²,

Achour³

et al. 2011

Journal Tunisien d'ORL Et De Chirurgie Cervico-Faciale

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SUMMARYPurpose: Mucosal melanoma of the upper respiratory tract is rare. Nasopharyngeal involvement is extremely rare. The diagnosis and management of this tumour still remain difficult. We present a new case of mucosal nasopharyngeal melanoma, to discuss diagnosis and therapeutic modalities. Observation: A 15-year-old girl was referred to the department of otolaryngology because of bilateral cervical mass with bilateral nasal obstruction, right otalgia and chronic headache. Nasopharyngeal tumour was observed endoscopically. The histologic examination showed mucosal melanoma. No distant metastatic localisations were identified. The patient underwent cervical lymph node dissection followed by 6 courses of chemotherapy, but she died 9 months later because of loco-regional failures. Conclusion:The primary malignant melanoma of nasopharyngeal is extremely rare disease particularly among child. Its histologic diagnosis is challenging. The treatment still remains controversial. The prognosis is poor because of anatomic localisation and high frequency of distant metastasis.

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A multi-institutional retrospective analysis of external radiotherapy for mucosal melanoma of the head and neck in Northern Japan

Cited by 99 publications

References 17 publications

Clinical analysis of 29 cases of nasal mucosal malignant melanoma

Clinical analysis of 29 cases of nasal mucosal malignant melanoma

Radiation Therapy for Melanoma

Localisation rare du melanome muqueux

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