Clinical analysis of 29 cases of nasal mucosal malignant melanoma

Abstract

Abstract. The present study aimed to investigate the clinical features of nasal mucosa malignant melanoma, including the histopathological features and factors affecting prognosis. A retrospective analysis of the clinical data obtained from the Department of Otolaryngology Head and Neck Surgery, Tianjin Huanhu Hospital (Tianjin, China) between October 1999 and June 2013 was performed using the Kaplan-Meier method. In total, 29 cases of nasal mucosal malignant melanoma were analyzed. The overall 3-and 5-year survival rates were 48.3 and 27.6%, respectively. The study group consisted of 18 males and 11 females, with a median age of 61.5 years. Overall, 19 patients underwent surgery, 28 received radiotherapy and 17 received chemotherapy. The American Joint Committee on Cancer staging system (AJCC) was used to retrospectively stage the tumors. In total, 8 were tumor stage (T)1, 10 were T2, 6 were T3 and 5 were T4. The results revealed that the T stage, surgical treatment, location of the tumor and the presence of black pigmentation affected the 5-year survival rate of the patients. By contrast, radiotherapy and chemotherapy had no effect on the overall survival rate. Overall, endoscopic or endoscopic-assisted surgery were the preferred methods of treatment, and histological features, including the presence of tumor melanin pigmentation, affected the prognosis of the patients. This study indicated that the AJCC staging system is able to effectively predict the prognosis of patients with nasal mucosa malignant melanoma.

Sinonasal mucosal melanoma: treatment strategies and survival rates for a rare disease entity

“…The vast majority of patients throughout the literature had either nasal obstruction or epistaxis or both as principle symptoms [ 5 , 9 , 14 , 18 , 19 , 33 – 36 , 40 , 41 ], which is in accordance with our patient series.…”

“…Information about radiation dose, fractionation and techniques is inconsistent and different radiation regimens have been presented. Moreno et al found improvement of locoregional control when a total dose of more than 54 Gy was used in a standard fractionation schedule [14], which was confirmed by Yu et al and Wada et al [41,49]. Meng et al and Caspers et al found improvement of local control giving mean total dosages of 63.4 Gy and 64 Gy, respectively [34,50].…”

“…2015 [ 9 ] 1994–2013 155 63 M: 81 F: 74 NC: 99 NS:54 MS:34 ES:28 FS: 6 SS: 6 SB: 6 Orbit: 9 NPX: 5 NLC: 3 Skin: 6 CA7: III: 67 IVA: 65 IVB: 9 IVC: 14 S: 48 S + RT: 54 S + Sys: 28 S + CRT: 11 UK: 14 OR: 63 incl ER:70 n/a 40.1 Yu et al. 2015 [ 41 ] 1999–2013 29 62 M:18 F:11 LNW: 12 NS: 7 MS:5 ES: 5 A6: T1: (34) T2: (34) T3: (21) T4: (17) S: 22 RT: 28 CT: 17 EA: 7 ER: 15 n/a 27.6 Huang et al. 2007 [ 5 ] 1994–2005 15 69 M: 8 F:7 n/a B: I: 14 II: 1 S + RT: 10 S + CRT: 3 CRT: 1 UK: 1 OR: 5 ER: 8 n/a 33 Ajmani et al.…”

Updates on Immunohistochemical and Molecular Markers in Selected Head and Neck Diagnostic Problems

“…26 There is a wide age range, between the second and ninth decade of life, with a mean age of 59.2 years. 27 Several studies 27,28 have shown there is a slight male predominance.…”

Data Set for the Reporting of Mucosal Melanomas of the Head and Neck: Explanations and Recommendations of the Guidelines From the International Collaboration on Cancer Reporting

“…The AJCC/UICC 8th edition staging systems, unchanged from the 7th edition, are based on the pathologic extent of disease (TNM), supported by several studies. 16,37,38 However, site-specific staging of sinonasal melanomas also stratified patients into prognostic groups. 39 This data set is applied to all upper aerodigestive tract sites, even though sinonasal tract disease forms the basis for the staging, 2,6 and previous staging proposals have been rendered obsolete.…”