A Morphometric and Histopathologic Evaluation of the Effects of Propolis on Alveolar Bone Loss in Experimental Periodontitis in Rats

Toker, Hülya; Özan, Fatih; Özer, Hatice; Özdemir, Hakan; Eren, Kaya; Yeler, Hasan

doi:10.1902/jop.2008.070462

Cited by 80 publications

(78 citation statements)

References 32 publications

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“…In many extant studies, the effects of antioxidants such as coenzyme Q 10 , propolis and N-acetylcysteine, vitamin C, cocoa, proanthosianidine, and statins have been evaluated in experimental periodontitis (30,(43)(44)(45)(46). However, no work has been done thus far on the antioxidant activity of melatonin upon heart tissue in the presence of periodontitis.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats

Özdem

Kırzıoğlu

Yilmaz

et al. 2017

Journal of Oral Science

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The aim of this study was to evaluate the effects of melatonin on the oxidative stress in heart tissues after induction of experimental periodontitis in rats. Thirty Wistar Albino male rats were divided into four groups as follows: healthy + saline solution (Hs, n = 7), healthy + melatonin (Hm, n = 7), periodontitis + saline solution (Ps, n = 8), and periodontitis + melatonin (Pm, n = 8). Experimental periodontitis was induced using a ligature placed at the gingival margin of the maxillary second molars. Melatonin was applied intraperitoneally (10 mg/ kg) every day for 2 weeks. After sacrificing the rats, serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) levels, and melatonin levels were evaluated. The Pm group exhibited lower alveolar bone loss than the Ps group. Melatonin levels increased in the periodontitis groups, and the Pm group had lower MDA levels and higher GSH-Px levels than the Ps group. These findings suggest that melatonin administration reduces MDA and increases GSH-Px levels in heart tissue, and these effects may be due to its antioxidant properties.Further studies are needed to understand the effects of melatonin on the association between periodontitis and cardiovascular disease.

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Section: Discussionmentioning

confidence: 99%

Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats

Özdem

Kırzıoğlu

Yilmaz

et al. 2017

Journal of Oral Science

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“…However, adverse effects are common at dosages .15 g/d in human and animal studies. 31,32 The most common adverse effects are allergic reactions and skin or mucous membrane irritations. 32 In our study we used propolis at a dose of 100 mg/kg and found no adverse effects.…”

Section: Discussionmentioning

confidence: 99%

Systemic propolis stimulates new bone formation at the expanded suture

Altan

Kara

Nalçacı

et al. 2012

The Angle Orthodontist

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Objective: To investigate the effects of systemically given propolis on the expanded premaxillary suture in a rat study model. Materials and Methods: The 24 rats were randomly divided into three groups-only expansion (OE), expansion plus propolis (PRO), and nonexpansion (control) groups. After the 5-day expansion period was completed, the OE and PRO groups underwent 12 days of mechanical retention. At the end of this period, the animals were euthanatized and their pre-maxillae were dissected and fixed. Histomorphometric examination was performed to determine the number of osteoclasts, osteoblasts, and capillaries as well as the intensity of inflammatory cells and amount of new bone formation. Results: Statistical analysis showed that the intensities of inflammatory cells, number of osteoblasts, and amount of new bone formation were greater in the PRO group than in the other groups. The PRO group also had more osteoclasts and new capillaries. Conclusion: Systemic use of propolis may hasten new bone formation at the expanded suture in rats. (Angle Orthod. 2013;83:286-291.)

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“…The rationale for using this experimental period is based on previous investigations. 13,15,23 According to Lima et al, 23 placement of a ligature around the molar teeth of rats leads to the presence of inflammatory cells, including osteoclasts, beneath the ligature. These authors reported that the substantial alveolar bone loss originated on day 3 of periodontitis induction reached a maximum between days 7 and 11.…”

Section: Discussionmentioning

confidence: 99%

“…The ligatures were kept in position in order to allow biofilm accumulation for 11days. 15,16 The contralateral tooth was left unligated for use as a control.…”

Section: Experimental Periodontal Diseasementioning

confidence: 99%

Evaluation of the effect of an organic extract obtained from Ipomoea alba L. on experimental periodontitis in rats

et al. 2012

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Evaluation of the effect of an organic extract obtained from Ipomoea alba L. on experimental periodontitis in rats Abstract: The aim of this study was to evaluate the effect of an organic extract obtained from Ipomoea alba L. (Convolvulaceae or OE 1493), on experimental periodontal disease in rats. Periodontitis was induced in thirty six Wistar rats: a first mandibular molar was randomly assigned to receive a ligature, whereas the contralateral molar was left unligated. Animals were randomly assigned to two groups and treated topically, three times a day, for 11 days, as follows: Control Group -vehicle-treated (n = 18), and Test Group -OE 1493-treated (n = 18). The rats were sacrificed on the 12 th day. Morphometrical measurements from the cementoenamel junction to the bone crest were performed to determine alveolar bone loss, using standardized photographs. Single-and multi-dose acute toxicity assays were carried out after OE 1493 treatment. Morphometrical analysis demonstrated that topically-administered OE 1493 showed no effect on reducing bone loss when compared with the control group (p > 0.05). In addition, OE 1493 did not present toxicity. Within the limits of this investigation, it may be concluded that OE 1493 did not show any positive influence on the progression of ligature-induced periodontitis in rats, when administered according to the regimen used in the present study.

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A Morphometric and Histopathologic Evaluation of the Effects of Propolis on Alveolar Bone Loss in Experimental Periodontitis in Rats

Abstract: The findings of this study provide morphologic and histologic evidence that propolis, when administered systemically, prevents alveolar bone loss in the rat model.

Cited by 80 publications

References 32 publications

Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats

Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats

Systemic propolis stimulates new bone formation at the expanded suture

Evaluation of the effect of an organic extract obtained from Ipomoea alba L. on experimental periodontitis in rats

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