Systemic propolis stimulates new bone formation at the expanded suture

Abstract

Objective: To investigate the effects of systemically given propolis on the expanded premaxillary suture in a rat study model. Materials and Methods: The 24 rats were randomly divided into three groups-only expansion (OE), expansion plus propolis (PRO), and nonexpansion (control) groups. After the 5-day expansion period was completed, the OE and PRO groups underwent 12 days of mechanical retention. At the end of this period, the animals were euthanatized and their pre-maxillae were dissected and fixed. Histomorphometric examination was performed to determine the number of osteoclasts, osteoblasts, and capillaries as well as the intensity of inflammatory cells and amount of new bone formation. Results: Statistical analysis showed that the intensities of inflammatory cells, number of osteoblasts, and amount of new bone formation were greater in the PRO group than in the other groups. The PRO group also had more osteoclasts and new capillaries. Conclusion: Systemic use of propolis may hasten new bone formation at the expanded suture in rats. (Angle Orthod. 2013;83:286-291.)

Does Propolis Help to Maintain Oral Health?

“…During the treatment bone remodeling takes place within the palatine suture. The research carried out by Altan et al on rats confirms positive effect of propolis solution on bone forming process during the treatment with the device to expand the palatine suture [68]. The results of the research show an increased quantity of osteoblasts in preparations from rats which received propolis during the treatment.…”

Evaluation of the Effect of Propolis on Implant Stability by Resonance Frequency Analysis and Removal Torque Test

“…There are many studies investigating the effects of propolis on bone. In a study by Altan et al, effect of systemically applied propolis on the expanded premaxillary suture was studied and it was thought that bone formation in this region could be accelerated [18]. In a study by Guney et al, effects of propolis on fracture healing were examined and the time-dependent, beneficial effects of propolis were discussed.…”

A Comparison of the Effects of Grayanotoxin-Containing Honey (Mad Honey), Normal Honey, and Propolis on Fracture Healing

“…Several studies have demonstrated the antioxidant property of propolis in tissues. In a histomorphometric study, Altan et al [13] showed that propolis stimulated new bone formation in bone suture separation and increased inflammatory cell numbers and capillary numbers in tissues. Guney et al [8] observed a positive effect of propolis on fracture healing; they reported that while radiological scores in the 3rd and 6th weeks were better compared to the control group, histological scores were comparable to those of the control group at the 6th week.…”