Radiation hardening techniques can be extensively used in the design level to improve the robustness of VLSI circuits used in space applications. Accordingly, this work analyzes the efficiency of transistor folding layout in improving the Single-Event Transient robustness of digital circuits. Additionally, diffusion splitting is proposed to reduce the area overhead of multiple-finger designs. Besides increasing threshold Linear Energy Transfer, results show that both techniques can also reduce the overall cross-section and the in-orbit SET rate for protons and heavy ions in LEO and ISS orbits.