A mononuclear zinc(II) complex with piroxicam: Crystal structure, DNA- and BSA-binding studies; in vitro cell cytotoxicity and molecular modeling of oxicam complexes

Jannesari, Zahra; Hadadzadeh, Hassan; Amirghofran, Zahra; Simpson, Jim; Khayamian, Taghi; Maleki, Batool

doi:10.1016/j.saa.2014.09.136

Cited by 25 publications

(10 citation statements)

References 64 publications

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“…The target sequences of virus and fluorescent dyes labeled complementary probe DNA were summarized in Table 2 . MOF could bind with DNA in a variety of ways, mainly including covalent, electrostatic, insert, or groove bonding ( Jannesari et al, 2015 ; Liu et al, 2020b ; Yang et al, 2019b ) ( Fig. 3 C).…”

Section: Viral Nucleic Acid Detection Based On Mofmentioning

confidence: 99%

Metal-organic frameworks for virus detection

Wang

et al. 2020

Biosensors and Bioelectronics

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Virus severely endangers human life and health, and the detection of viruses is essential for the prevention and treatment of associated diseases. Metal-organic framework (MOF), a novel hybrid porous material which is bridged by the metal clusters and organic linkers, has become a promising biosensor platform for virus detection due to its outstanding properties including high surface area, adjustable pore size, easy modification, etc. However, the MOF-based sensing platforms for virus detection are rarely summarized. This review systematically divided the detection platforms into nucleic acid and immunological (antigen and antibody) detection, and the underlying sensing mechanisms were interpreted. The nucleic acid sensing was discussed based on the properties of MOF (such as metal ion, functional group, geometry structure, size, porosity, stability, etc.), revealing the relationship between the sensing performance and properties of MOF. Moreover, antibodies sensing based on the fluorescence detection and antigens sensing based on molecular imprinting or electrochemical immunoassay were highlighted. Furthermore, the remaining challenges and future development of MOF for virus detection were further discussed and proposed. This review will provide valuable references for the construction of sophisticated sensing platform for the detection of viruses, especially the 2019 coronavirus.

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Section: Viral Nucleic Acid Detection Based On Mofmentioning

confidence: 99%

Metal-organic frameworks for virus detection

Wang

et al. 2020

Biosensors and Bioelectronics

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“…For example meloxicam acted as monodentate nitrogen donor ligand to Pt II , and coordinated in a bidentate fashion to Ni II through the thiazole nitrogen and amidate oxygen atoms . Similarly, piroxicam coordinated monodentately to Ru II (arene), by its pyridyl nitrogen, and it can act also as an N,O ‐chelator through its amidate oxygen and pyridyl nitrogen to metal ions such as Co II , Ru II , Cu II , and Zn II . In case of hard Sn IV , piroxicam coordinated as an O,O ‐chelator via its enolate and amidate oxygen atoms, whereas the analogous benzothiazine lornoxicam coordinated as a tridentate N , N,O ‐chelator by employing an enolate oxygen and pyridyl and amide nitrogen donors.…”

Section: Introductionmentioning

confidence: 99%

“…In case of hard Sn IV , piroxicam coordinated as an O,O ‐chelator via its enolate and amidate oxygen atoms, whereas the analogous benzothiazine lornoxicam coordinated as a tridentate N , N,O ‐chelator by employing an enolate oxygen and pyridyl and amide nitrogen donors. Many of the metal complexes of oxicam‐based ligands have demonstrated biological applications, such as in DNA cleavage, or as antitumor agents …”

Section: Introductionmentioning

confidence: 99%

Anti‐Inflammatory Oxicams as Multi‐donor Ligand Systems: pH‐ and Solvent‐Dependent Coordination Modes of Meloxicam and Piroxicam to Ru and Os

Aman

Hanif

Kubanik

et al. 2017

Chemistry A European J

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The nitrogen- and sulfur-containing 1,2-benzothiazines meloxicam and piroxicam are widely used as nonsteroidal anti-inflammatory drugs. Intrigued by the presence of multiple donor atoms and therefore potentially rich coordination chemistry, we prepared a series of organometallic Ru and Os compounds with meloxicam and piroxicam featuring either as mono- or bidentate ligand systems. The choice of the solvent and the pH value was identified as the critical parameter to achieve selectively mono- or bidentate coordination. The coordination modes were confirmed experimentally by NMR spectroscopy and single crystal X-ray diffraction analysis. Using DFT calculations, it was established that complexes in which meloxicam acts as a bidentate N,O donor are energetically more favorable than coordination as O,O and S,O donor systems. Since meloxicam and piroxicam derivatives have shown anticancer activity in the past, we aimed to compare the complexes with mono- and bidentate ligands on their in vitro anticancer activity. However, stability studies revealed that only the latter complexes were stable in [D ]DMSO/D O (5:95) and therefore no direct comparisons could be made. The meloxicam complexes 1 and 2 showed moderate cytotoxicity, whereas the piroxicam derivatives 5 and 6 were hardly active against the utilized cell lines.

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“…Synthesis of Bi-complex was carried out according to previously reported procedure with minor modifications [2]. Na-piroxicam was made by adding 0.001 g of NaOH in ethanolic solution of piroxicam (0.09 g, 0.3 mmol).…”

Section: Synthesismentioning

confidence: 99%

“…Piroxicam [4-hydroxy-2-methyl-N-2-(pyridyl)-2H-1,2benzothiazine-3-carboxamide 1,1-dioxide] is a very effective antiinflammatory drug and biologically active as an analgesic, antipyretic, hypoglycemic and antihypertensive [1]. Chemo preventive and chemo suppressive effects in different cancers i.e colon, lung and breast cancers have also been studied [2]. This important member of oxicam class is a strong chelator for d-block divalent metal ions of the periodic table, via nitrogen atoms from the pyridyl the amide oxygen atom or thiazolyl rings [3].…”

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confidence: 99%

Synthesis and Structural Studies of Bismuth-piroxicam Complex

Kanwal¹,

Imran²,

Iqbal³

et al. 2018

Rev. Chim.

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Piroxicam [4-hydroxy-2-methyl-N-2-(pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide] is an effective antiinflammatory analgesic drug. In the present work, piroxicam has been chemically modified into its bismuth complex by reacting it with bismuth nitrate at ambient conditions and optimized stoichiometric ratio. The synthesis of the complex has been monitored by TLC and characterized well by Fourier Transform Infrared (FTIR), UV-Vis, ICP, TGA, XRD and SEM. The luminescent behavior of this complex has also been studied which determined its photoluminescent property.

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A mononuclear zinc(II) complex with piroxicam: Crystal structure, DNA- and BSA-binding studies; in vitro cell cytotoxicity and molecular modeling of oxicam complexes

Cited by 25 publications

References 64 publications

Metal-organic frameworks for virus detection

Metal-organic frameworks for virus detection

Anti‐Inflammatory Oxicams as Multi‐donor Ligand Systems: pH‐ and Solvent‐Dependent Coordination Modes of Meloxicam and Piroxicam to Ru and Os

Synthesis and Structural Studies of Bismuth-piroxicam Complex

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