Synthesis and Structural Studies of Bismuth-piroxicam Complex

Kanwal, Ayesha; Imran, Muhammad; Iqbal, Zafar; Rehman, Summia; Danish, Zeeshan; Batool, Nayab; Mitu, Liviu

doi:10.37358/rc.18.7.6399

Cited by 4 publications

(4 citation statements)

References 13 publications

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“…From the electronic spectrum of the complex the geometry of the metallic ion cannot be precise but taking in consideration the ligand functions in a bidentate form as well as the tendency of the Zn(II) ion for the tetrahedral stereochemistry in the tetra-coordination complexes, we suggest a tetrahedral configuration [23]. The shifting of bands inBi(III) complex towards bathochromicregion when compared with LH indicate the involvement of ligand (LH) in the chelation with Bi(III) ion [24].…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Structural Characterization and Biological Studies of Metal Complexes with (E)-4-oxo-4-(thiazol-2-ylamino)but-2-enoic Acid

Rehman¹,

Imran²,

Kanwal³

et al. 2020

Rev. Chim.

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Carboxylate functionalized ligand (LH) was synthesized as a result of reaction between maleic anhydride and 2�aminothiazole. This ligand was further reacted with Co(II), Ni(II), Cu(II), Zn(II) and Bi(III) ions to yield respective metal complexes. The structural aspects were studied using FTIR, UV�Visible and 1H-NMR spectroscopy. Non-electrolytic behavior was revealed by the conductivity measurements. Except Bi(III) being octahedral, all other complexes prepared are tetrahedral in geometry. Ligand (LH) and its metal complexes were also investigated for their in vitro antibacterial and antifungal activities. All the complexes exhibited significant antibacterial activity but non-significant antifungal activity.

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Section: Resultsmentioning

confidence: 99%

Synthesis, Structural Characterization and Biological Studies of Metal Complexes with (E)-4-oxo-4-(thiazol-2-ylamino)but-2-enoic Acid

Rehman¹,

Imran²,

Kanwal³

et al. 2020

Rev. Chim.

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“…SEM analysis depicted significant changes in the shape and surface morphology of Ca(II) complex which occurred due to the complexation, and it might improve the properties of meloxicam. The cavities in the crystal system could be used for the electrostatic drug loading [ 22 ]. The EDS is used to calculate the percentage level of the elements present in the metal complexes like C, O, N, S and respective metal present in the complex [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

“…The precipitates were filtered, washed with hot ethanol and then dried at ambient temperature. The overnight stirring was done to obtain good yield of calcium metal complex which is difficult to achieve due to inert nature of calcium metal as compared to reactive metals we reported in our previous work [ 22 ].…”

Section: Methodsmentioning

confidence: 99%

Synthesis, Spectroscopic and Biological Investigation of a New Ca(II) Complex of Meloxicam as Potential COX-2 Inhibitor

et al. 2022

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Drug development on basis of coordination compounds provides versatile structural and functional properties as compared to other organic compounds. In the present study, a new Ca(II) complex of meloxicam was synthesized and characterized by elemental analysis, FT-IR, UV–Vis, 13 C NMR, SEM–EDX, powder XRD and thermal analysis (TGA). The Ca(II) complex was investigated for its in vitro, in vivo biological activities and in silico docking analysis against COX-1 and COX-2. The spectral analysis indicates that the meloxicam acts as a deprotonated bidentate ligand (coordinated to the metal atom through the amide oxygen and the nitrogen atom of the thiazolyl ring) in the complex. SEM–EDX and powder XRD analysis depicted crystalline morphology of Ca(II) complex with a crystalline size of 32.86 nm. The in vitro biological activities were evaluated by five different antioxidant methods and COX inhibition assay, while in vivo activities were evaluated by carrageenan-, histamine- and PGE 2 -induced paw edema methods and acetic acid-induced writhing test. The Ca(II) complex showed prominent antioxidant activities and was found to be more selective toward COX-2 (43.77) than COX-1 as compared to meloxicam. It exhibited lower toxicity (LD 50 1000 mg/Kg) and significantly inhibited carrageenan- and PGE 2 -induced inflammation at 10 mg/Kg ( P < 0.05), but no significant effect was observed on histamine-induced inflammation. Moreover, Ca(II) complex significantly reduced the number of writhes induced by acetic acid ( P < 0.05). The in silico molecular docking data revealed that Ca(II) complex obstructed COX-2 (dock score 6438) more effectively than COX-1 (dock score 5732) as compared to meloxicam alone.

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“…The MDCs of mefenamic acid with manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II) show anti-inflammatory, antioxidant as well as antiproliferative potentials [127,128]. The MDC of bismuth(III) with lapachol and piroxicam show anti-inflammatory potentials [129,130]. The gold(I) MDC known as auranofin shows antiinflammatory potential but its effectiveness is lesser than standard drugs [131].…”

Section: Nsaid-mdcsmentioning

confidence: 99%

Calcium Complexes of Oxicams: New Dimensions in Rheumatoid Arthritis Treatment

et al. 2022

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Various metals have been complexed with drugs to improve their cellular impact. Inflammatory diseases like rheumatoid arthritis (RA) are characterized by unbalanced production of proinflammatory cytokines (PICs) and prostaglandins with decreased levels of vitamin D and calcium. The inflammation can be suppressed through targeting the formation of PICs or related enzymes by various treatment strategies that involve the use of corticosteroids, disease-modifying antirheumatic drugs and NSAIDs. We present a detailed review on the impact of calcium complexes of oxicams as an advanced treatment strategy for RA. The calcium complexes demonstrate promising capabilities to cure the disease, improve the strength of bones and suppress PICs in RA.

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Synthesis and Structural Studies of Bismuth-piroxicam Complex

Cited by 4 publications

References 13 publications

Synthesis, Structural Characterization and Biological Studies of Metal Complexes with (E)-4-oxo-4-(thiazol-2-ylamino)but-2-enoic Acid

Synthesis, Structural Characterization and Biological Studies of Metal Complexes with (E)-4-oxo-4-(thiazol-2-ylamino)but-2-enoic Acid

Synthesis, Spectroscopic and Biological Investigation of a New Ca(II) Complex of Meloxicam as Potential COX-2 Inhibitor

Calcium Complexes of Oxicams: New Dimensions in Rheumatoid Arthritis Treatment

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