Synthesis, Structural Characterization and Biological Studies of Metal Complexes with (E)-4-oxo-4-(thiazol-2-ylamino)but-2-enoic Acid

Abstract

<jats:p> Carboxylate functionalized ligand (LH) was synthesized as a result of reaction between maleic anhydride and 2�aminothiazole. This ligand was further reacted with Co(II), Ni(II), Cu(II), Zn(II) and Bi(III) ions to yield respective metal complexes. The structural aspects were studied using FTIR, UV�Visible and 1H-NMR spectroscopy. Non-electrolytic behavior was revealed by the conductivity measurements. Except Bi(III) being octahedral, all other complexes prepared are tetrahedral in geometry. Ligand (LH) and its metal complexes were also investigated for their in vitro antibacterial and antifungal activities. All the complexes exhibited significant antibacterial activity but non-significant antifungal activity. </jats:p>