A Molecular Communication System in Blood Vessels for Tumor Detection

Felicetti, Luca; Femminella, Mauro; Reali, Gianluca; Lió, Píetro

doi:10.1145/2619955.2619978

Cited by 38 publications

(39 citation statements)

References 33 publications

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“…where d optimal = j means that the detector selects hypothesis H j , j = 0, 1. In (30), LLR( ì a M ) is given by 20 In the following, we derive LLR( ì a M ) for the problem at hand. Since the movements of different MNSs are independent, the activation levels of different MNSs are statistically independent, which results in…”

Section: Mns Activation Level Statisticmentioning

confidence: 99%

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Early Cancer Detection in Blood Vessels Using Mobile Nanosensors

Mosayebi

Ahmadzadeh

Wicke

et al. 2019

IEEE Trans.on Nanobioscience

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In this paper, we propose using mobile nanosensors (MNSs) for early stage anomaly detection. For concreteness, we focus on the detection of cancer cells located in a particular region of a blood vessel.These cancer cells produce and emit special molecules, so-called biomarkers, which are symptomatic for the presence of anomaly, into the cardiovascular system. Detection of cancer biomarkers with conventional blood tests is difficult in the early stages of a cancer due to the very low concentration of the biomarkers in the samples taken. However, close to the cancer cells, the concentration of the cancer biomarkers is high. Hence, detection is possible if a sensor with the ability to detect these biomarkers is placed in the vicinity of the cancer cells. Therefore, in this paper, we study the use of MNSs that are injected at a suitable injection site and can move through the blood vessels of the cardiovascular system, which potentially contain cancer cells. These MNSs can be activated by the biomarkers close to the cancer cells, where the biomarker concentration is sufficiently high. Eventually, the MNSs are collected by a fusion center (FC) where their activation levels are read and exploited to declare the presence of anomaly. We analytically derive the biomarker concentration in cancerous blood vessels as well as the probability mass function of the MNSs' activation levels and validate the obtained results via particle-based simulations. Then, we derive the optimal decision rule for the FC regarding the presence of anomaly assuming that the entire network is known at the FC. Finally, for the FC, we propose a simple sum detector that does not require knowledge of the network topology. Our simulations reveal that while the LRT detector achieves a higher performance than the sum detector, both proposed detectors significantly outperform a benchmark scheme that uses fixed nanosensors at the FC.

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Section: Mns Activation Level Statisticmentioning

confidence: 99%

“…However, both [18] and [19] assume that the nanosensors are fixed, i.e., they do not move inside the CS. In [20], an MC system for tumor detection in blood vessels is proposed. In this work, the authors assume that specific nanorobots are injected into the CS which are attracted by the tumor cells.…”

Section: Introductionmentioning

confidence: 99%

Early Cancer Detection in Blood Vessels Using Mobile Nanosensors

Mosayebi

Ahmadzadeh

Wicke

et al. 2019

IEEE Trans.on Nanobioscience

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“…A promising application area for the nanoscale communications is that of the diagnosis of diseases. For instance, the identification of tumors is particularly well suited to be achieved through molecular communications [20] [21]. The basic idea consists of monitoring the concentration of specific biomarkers in the cardiocirculatory system.…”

Section: Disease Detectionmentioning

confidence: 99%

Applications of molecular communications to medicine: A survey

Felicetti

Femminella

Reali

et al. 2016

Nano Communication Networks

145

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In recent years, progresses in nanotechnology have established the foundations for implementing nanomachines capable of carrying out simple but significant tasks. Under this stimulus, researchers have been proposing various solutions for realizing nanoscale communications, considering both electromagnetic and biological communications. Their aim is to extend the capabilities of nanodevices, so as to enable the execution of more complex tasks by means of mutual coordination, achievable through communications.However, although most of these proposals show how devices can communicate at the nanoscales, they leave in the background specific applications of these new technologies. Thus, this paper shows an overview of the actual and potential applications that can rely on a specific class of such communications techniques, commonly referred to as molecular communications. In particular, we focus on health-related applications. This decision is due to the rapidly increasing interests of research communities and companies to minimally invasive, biocompatible, and targeted health-care solutions. Molecular communication techniques have actually the potentials of becoming the main technology for implementing advanced medical solution.Hence, in this paper we provide a taxonomy of potential applications, illustrate them in some details, alongwith the existing open challenges for them to be actually deployed, and draw future perspectives.

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“…The choice of an architecture for a bio-cyber interface will depend on the nature of the signal, the channel through which the signal in propagated and the task at hand. Some proposals to address the interface issue have been presented in [32][33][34].…”

Section: Bio-cyber Interface Architecture and Modelmentioning

confidence: 99%