Biologically Inspired Bio-Cyber Interface Architecture and Model for Internet of Bio-NanoThings Applications

Chude-Okonkwo, Uche A. K.; Malekian, Reza; Maharaj, B. T.

doi:10.1109/tcomm.2016.2582870

Cited by 39 publications

(57 citation statements)

References 61 publications

(72 reference statements)

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“…Inspired by the derivation of channel capacity in the diffusion-based MolCom system, 10 we can obtain a closed form of mutual information in the IoBNT paradigm that represents each block in biocyber interface. Subsequently, the channel capacity or mutual information can be provided through the uplink biocyber interface wherein it is important to recall that, the main aim of MolCom system is to report the doctor or the medical personnel about the patient status throughout monitoring the concentration of drugs as well as the detection of the biochemical reaction at the targeted diseased cell.…”

Section: Channel Capacity Of Iobnt Paradigmmentioning

confidence: 99%

“…In the MolCom system, the nanoscale information transfers between nanotransmitter and nanoreceiver in the form of molecules instead of electromagnetic (EM) wave. [5][6][7][8][9] On the other hand, the Internet [10]. The main application of the MolCom system is in the field of nanomedical and drug delivery system.…”

Section: Introductionmentioning

confidence: 99%

“…1 Additionally, the Forster resonance energy transfer (FRET) phenomenon has been exploited to transfer nanoscale information in the form of exciton [31]. Uche et al 10 have presented an exemplified model responsive to thermal and optical stimulation; however, the design was isolated from the targeted nanonetwork, and it was focusing on studying the effect of the proposed compartment model parameters, while the physical characteristics of targeted nanonetwork such as density and size of nanomachines that aimed to carry the drugs information are not considered. [2][3][4] Moreover, the nanotechnology has enabled us to fabricate a nanomachine that simulates the biological cell namely biological nanomachine.…”

Section: Introductionmentioning

confidence: 99%

“…The main application of the MolCom system is in the field of nanomedical and drug delivery system. On the other hand, the compartmental model 10 was based on traditional technology by implementing logic gate circuit inside the intrabody nanonetwork, and thus the feasibility of side effects is not addressed. The MolCom system is a fundamentally suited model for interconnecting these biological nanomachines over nanoscale-range short distances to perform simple-single tasks, and by using the communication network theories such as coding/decoding, processing, and relay basis, they can perform complex tasks.…”

Section: Introductionmentioning

confidence: 99%

“…The MolCom system is a fundamentally suited model for interconnecting these biological nanomachines over nanoscale-range short distances to perform simple-single tasks, and by using the communication network theories such as coding/decoding, processing, and relay basis, they can perform complex tasks. [5][6][7][8][9] On the other hand, the Internet of Biological NanoThing (IoBNT) is a novel paradigm, interconnects a macroscale network (ie, Internet cyber domain) with nanoscale network (ie, biological intrahuman body) [10]. The IoBNT and MolCom system can be jointed in order to use in new applications such as health monitoring, health care and smart/targeted drug delivery (TDD) system.…”

Section: Introductionmentioning

confidence: 99%

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MolCom system with downlink/uplink biocyber interface for Internet of Bio‐NanoThings

El-atty

Bidar

El-Rabaie

2019

Int J Communication

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Inspired by wireless communication systems, we propose a feasible downlink/uplink biocyber interface for the expected targeted drug delivery system based on Internet of Biological NanoThing (IoBNT) paradigm. The downlink/uplink biocyber interface of IoBNT comprises Fluorescence Resonance Energy Transfer (FRET) and Molecular Communication (MolCom) technology. On the downlink (from Internet to targeted nanonetwork), the biocyber interface transduces electromagnetic (EM) signal to biochemical signals, and thus with the help of mobile MolCom system based on FRET nanocommunication, the drug information delivers to the diseased cell within the targeted intrabody nanonetwork. On the uplink, the MolCom system consists of embedded sensor/actuator nanonetwork to detect the biochemical changes in the targeted cell, and hence biocyber interface transduces the biochemical signal to EM signal. As a result, the paradigm of IoBNT responses by proper functions to these changes according to the decision of medical health care. The performance analysis of the proposed IoBNT system is numerically investigated through MolCom system-based FRET, while the performance evaluation is evaluated by employing spreading epidemic scheme in terms of success-ful probability of drug delivery, channel capacity, average drug-delivery time, and throughput. The simulation results show that the proposed IoBNT is a promising paradigm for smart drug delivery system, and its performance is mainly based on the nanostructure and the characteristic of molecular nanomachines in the targeted nanonetwork.

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Section: Channel Capacity Of Iobnt Paradigmmentioning

confidence: 99%