“…By taking the advantage of such the noncovalent nature of the RNP complex, RNP sensors with desired affinity, selectivity and optical sensing properties could be selected in a high-throughput manner by combining a series of RNA subunits derived from each of the library. Actually, a variety of fluorescent biosensors for targeting ATP (Hagihara, M. et al 2006), GTP (Hagihara, M. et al 2006), histamine (Fukuda, M. et al 2009), phosphotyrosine (Hasegawa, T. et al 2005), and phosphotyrosinecontaining peptide fragment (Hasegawa, T. et al 2008) have been produced by the group, showing the generality of the approach. Recently, the group showed that ATP-binding RNP sensor was rationally converted to GTP-binding RNP sensor to have realized the detail of the recognition mechanism (Nakano, S. et al 2011).…”