A modern literature review of carbon monoxide poisoning theories, therapies, and potential targets for therapy advancement.

Roderique, Joseph D.; Josef, Christopher S.; Feldman, Michael J.; Spiess, Bruce D.

doi:10.1016/j.tox.2015.05.004

Cited by 126 publications

(78 citation statements)

References 138 publications

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“…Dennoch versagten zwei CochraneAnalysen beim Versuch, einen positiven Effekt der hyperbaren Oxygenierung bei Kohlenmonoxidvergiftung zu bestätigen [416,418]. Die Rolle von Kohlenmonoxid in der Stickoxidfreisetzung, in der reaktiven Sauerstoffformation und der direkten Wirkung auf die Ionenkanäle scheint signifikanter zu sein als die höhere Affinität zu Hämoglobin, das mit Sauerstoff therapiert wird [419]. Da der Vorteil des Transports eines kritisch kranken Patienten nach erfolgreicher Reanimation zu einem Hyperbaren Therapiezentrum nicht erwiesen ist, muss hier jeweils von Fall zu Fall entschieden werden [413,416,418,419] …”

Section: Kohlenmonoxidunclassified

Kreislaufstillstand in besonderen Situationen

Truhlář

Deakin

Soar

et al. 2015

Notfall Rettungsmed

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Section: Kohlenmonoxidunclassified

Kreislaufstillstand in besonderen Situationen

Truhlář

Deakin

Soar

et al. 2015

Notfall Rettungsmed

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“…92,102,106,133 Briefly, the toxic effects of CO extend beyond simple hypoxia and include the binding of CO to other heme proteins impairing mitochondrial function, as well as proinflammatory effects leading to neutrophil degranulation, platelet-neutrophil aggregation, and production of reactive oxygen species. 102,106,133 If the animal survives a period of time, lesions produced are a result of hypoxia and direct toxicity affecting primarily the brain 69,92,137 and heart. 87,89 Carboxyhemoglobin is stable in tissues, and the cherry red color of soft tissues is usually maintained in the body; however, this should 83 Carboxyhemoglobin is also remarkably stable in stored blood samples for weeks or even months.…”

Section: 3153mentioning

confidence: 99%

“…137 Demyelination of the deep white matter occurs in people and cats. 88,106 The distribution of brain lesions in CO toxicity is thought to be related to the blood supply, hypotension, hypoxia, and direct cytotoxicity. [87][88][89] Coagulation necrosis of cardiac myofibers with CO toxicity is also reported in cats 89 and people.…”

Section: Lesions Of Suffocationmentioning

confidence: 99%

Nondrowning Asphyxia in Veterinary Forensic Pathology

McEwen

2016

Vet Pathol

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Asphyxia in a forensic context refers to death by rapid cerebral anoxia or hypoxia due to accidental or nonaccidental injury. Death due to nondrowning asphyxia can occur with strangulation, suffocation, and mechanical asphyxia, each of which is categorized based on the mechanism of injury. Individuals dying due to various types of asphyxia may or may not have lesions, and even those lesions that are present may be due to other causes. The interpretation or opinion that death was due to asphyxia requires definitive and compelling evidence from the postmortem examination, death scene, and/or history. Beyond the postmortem examination, pathologists may be faced with questions of forensic importance that revolve around the behavioral and physiological responses in animals subjected to strangulation, suffocation, or mechanical asphyxia to determine if the animal suffered. While there is no prescriptive answer to these questions, it is apparent that, because of physiological and anatomical differences between humans and animals, for some mechanisms of asphyxia, consciousness is maintained for longer periods and the onset of death is later in animals than that described for people. Veterinary pathologists must be cognizant that direct extrapolation from the medical forensic literature to animals may be incorrect. This article reviews the terminology, classification, mechanisms, and lesions associated with asphyxial deaths in companion animals and highlights significant comparative differences of the response to various types of asphyxia in animals and people.

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“…We read with great interest the review article entitled 'A modern literature review of carbon monoxide (CO) poisoning therories, therapies, and potential targets for therapy advancement' by Roderique et al (2015). The authors pointed out a couple of important topics; identifying the flaws in the current carboxyhemoglobin theory of CO poisoning, continuing to expand on the gasotransmitter model of CO, reconsidering the appropriateness of the currently propagated pathophsysiology, and offering targets for new therapeutic interventions.…”

Section: Dear Editormentioning

confidence: 99%