A model for the chemomechanical coupling of the mammalian cytoplasmic dynein molecular motor

Xie, Ping

doi:10.1007/s00249-019-01386-z

Cited by 3 publications

(1 citation statement)

References 40 publications

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“…As shown by previous modeling studies, the cytoplasmic dynein dimer could have a similar chemomechanical coupling pathway to the kinesin dimer. [37] Thus, it is expected that α = 1.8 obtained here for a kinesin motor should be consistent with that obtained by fitting the experimental data of Cleary et al [36] to the theoretical equations for a dynein motor.…”

Section: Comparison Of the Relationship Between Velocity And Attachme...supporting

confidence: 88%

Origin of tradeoff between movement velocity and attachment duration of kinesin motor on a microtubule

Liu 刘,

Zhang 张

2024

Chinese Phys. B

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Kinesin-1 motor protein is a homodimer containing two identical motor domains connected together by a common long coiled-coil stalk via two flexible neck linkers. The motor can step on microtubule with a velocity of about 1 μm/s and an attachment duration of about 1 s under the physiological condition. The available experimental data indicated the tradeoff between the velocity and attachment duration under the variation of different experimental conditions, such as the variation of the solution temperature, the variation of the strain between the two motor domains, and so on. However, the underlying mechanism of the tradeoff is unknown. Here, the mechanism is explained by studying theoretically the dynamics of the motor under the variation of different experimental conditions, reproducing quantitatively the available experimental data and providing additional predictions. The origin of the variation of different experimental conditions leading to different decreasing rates of the attachment duration versus velocity is also explained.

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Section: Comparison Of the Relationship Between Velocity And Attachme...supporting

confidence: 88%

Origin of tradeoff between movement velocity and attachment duration of kinesin motor on a microtubule

Liu 刘,

Zhang 张

2024

Chinese Phys. B

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Non-tight and tight chemomechanical couplings of biomolecular motors under hindering loads

Xie

2020

Journal of Theoretical Biology

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Role of Dynein and Dynactin (DCTN-1) in Neurodegenerative Diseases

Dutta¹,

Sarkar²

2019

NPR

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The pathophysiology and concept of degeneration in central nervous system is very complex and overwhelming at times. There is a complex mechanism which exists among different molecules in the cytoplasm of cell bodies of neurons, antegrade and retrograde axonal transport of cargoes and accumulation of certain substances and proteins which can influence the excitatory neurotransmitter like glutamate initiating the process of neurodegeneration. Neurons have extensive processes and communication between those processes and the cell body is crucial to neuronal function, viability and survival over time with progression of age. Researchers believe neurons are uniquely dependent on microtubule-based cargo transport. There is enough evidence to support that deficits in retrograde axonal transport contribute to pathogenesis in multiple neurodegenerative diseases. Cytoplasmic dynein and its regulation by Dynactin (DCTN1) is the major molecular motor cargo involved in autophagy, mitosis and neuronal cell survival. Mutation in dynactin gene located in 2p13.1,is indeed studied very extensively and is considered to be involved directly or indirectly to various conditions like Perry syndrome, familial and sporadic Amyotrophic lateral sclerosis, Hereditary spastic paraplegia, Spinocerebellar Ataxia (SCA-5), Huntingtons disease, Alzheimers disease, Charcot marie tooth disease, Hereditary motor neuropathy 7B, prion disease, parkinsons disease, malformation of cortical development, polymicrogyria to name a few with exception of Multiple Sclerosis (MS).

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A model for the chemomechanical coupling of the mammalian cytoplasmic dynein molecular motor

Cited by 3 publications

References 40 publications

Origin of tradeoff between movement velocity and attachment duration of kinesin motor on a microtubule

Origin of tradeoff between movement velocity and attachment duration of kinesin motor on a microtubule

Non-tight and tight chemomechanical couplings of biomolecular motors under hindering loads

Role of Dynein and Dynactin (DCTN-1) in Neurodegenerative Diseases

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