A Missing Link: Sarcoid-Lymphoma Syndrome

Kumthekar, Anand; Raess, Philipp W.; Ghetie, Daniela

doi:10.1016/j.amjmed.2018.07.034

Cited by 7 publications

(5 citation statements)

References 16 publications

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“…So, the question is: was the spleen biopsy misleading or did the patient have sarcoid-lymphoma syndrome? [4,11] . A multicentre Italian study reported experience with percutaneous ultrasound-guided fine needle aspiration biopsy of the spleen in 398 patients [12] .…”

Section: Discussionmentioning

confidence: 99%

Sarcoidosis Versus Lymphoma?

Lago

Sarrand

Woff

et al. 2021

European Journal of Case Reports in Internal Medicine

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An association between lymphoma and sarcoidosis was first suggested in 1960. We report a case of sarcoidosis-lymphoma syndrome, which is a diagnostically challenging condition. We conclude that an associated lymphoma should be considered in all patients with suspected sarcoidosis, especially those who do not respond to treatment or who present with persistent haematological abnormalities. Splenomegaly should prompt splenectomy to rule out lymphoma if a less invasive approach has failed to confirm the diagnosis.

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Section: Discussionmentioning

confidence: 99%

Sarcoidosis Versus Lymphoma?

Lago

Sarrand

Woff

et al. 2021

European Journal of Case Reports in Internal Medicine

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“…However, of interest is the simultaneous or consecutive presentation of sarcoidosis and lymphoma in the same patient (Brincker, 1986;Brincker, 1989;Kumthekar et al, 2019;Oskuei et al, 2017;Papanikolaou & Sharma, 2010). Various groups of investigators support the thesis that there is a link between sarcoidosis and lymphoma (Karakantza et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

“…There are a number of publications that examine the possibility of an association between sarcoidosis and lymphoproliferative diseases (LPD) (heterogeneous types of lymphoma) within the so-called sarcoid-lymphoma syndrome (Kumthekar, Raess, & Ghetie, 2019;Oskuei, Hicks, Ghaffar, & Hoffstein, 2017). In the presence of hilar/ mediastinal lymphadenopathy, both diseases should be considered in a differential diagnosis, but also the possibility of coexistence within the same patient should not be excluded (Oskuei et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…There are a number of publications that examine the possibility of an association between sarcoidosis and lymphoproliferative diseases (LPD) (heterogeneous types of lymphoma) within the so-called sarcoid-lymphoma syndrome (Kumthekar, Raess, & Ghetie, 2019;Oskuei, Hicks, Ghaffar, & Hoffstein, 2017). The possibility that disturbance of tissue homeostasis by incorporation of certain adjuvants within injections (for example) in the past might have been an inducer of cutaneous T cell lymphoma and sarcoidosis/ sarcoid like lesions seems reasonable but also speculative.…”

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confidence: 99%

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Granulomatous slack skin mycosis fungoides developing simultaneously with sarcoid‐like lesions in a patient with repeated anabolic injections in the past?

Tchernev¹,

Patterson

Wollina³

et al. 2020

Dermatologic Therapy

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We present a 32-year-old man with successful treatment and remission of mycosis fungoides of both axillae in 2016 after PUVA therapy and systemic and local administration of corticosteroids. Subsequently, in 2017, the patient also achieved remission of a T-cell CD 30 positive, ALK-1 negative large-cell lymphoma of a retroperitoneal and inguinal lymph node after chemotherapy and radiotherapy. One year later, in 2018, the patient presented to our clinic with progression of skin lesions in both axillary areas and the appearance of а tumor in the right gluteal region.Dermatological

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“…Longstanding inflammation and immune dysregulation may be risk factors for developing malignancy [21]. Release of some inflammatory cytokines, activation of Th1/Th17 cells, decreased regulatory T-cells and impaired CD4 T-cells, may promote the proliferation of cells and blood vessels, tissue remodeling, and stromal growth leading to a tumor [22].…”

Section: Pathology Of Sarcoidosis Association With Other Disorders/malignancymentioning

confidence: 99%

Sarcoidosis: Various Presentations, Coexisting Diseases and Malignancies

Gaddam¹,

Ojinnaka²,

Ahmed³

et al. 2021

Cureus

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Sarcoidosis is a rare, chronic inflammatory disease with a characteristic non-caseating granuloma formation. It affects women more than men. The lung is the most commonly affected organ, however, extrapulmonary involvement is also seen. Sarcoidosis can affect any organ or tissue and can also involve multiple organs simultaneously. As a disease, it shares clinical symptoms with a variety of autoimmune, non-autoimmune disorders and malignancies. Not only it mimics clinically, but it also coexists with these diseases, posing a significant diagnostic challenge. During this literature review, we obtained data from the previously published PubMed articles within the last five years and reviewed the possible etiological association and clinical coexistence between sarcoidosis and other diseases/malignancies. We aimed to determine the common clinical manifestations, various complex presentations of sarcoidosis and pathophysiological considerations for the association, and to emphasize the link with other diseases, particularly thyroid disorders/malignancies. Physicians should be aware of these associated diseases and should always make a clinical suspicion when confronting a sarcoidosis patient. Thus, a comprehensive diagnostic evaluation for these associated conditions ought to be done in sarcoidosis patients to avoid any delay in the curative treatment for these coexisting diseases and to prevent substandard outcomes.

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A Missing Link: Sarcoid-Lymphoma Syndrome

Cited by 7 publications

References 16 publications

Sarcoidosis Versus Lymphoma?

Sarcoidosis Versus Lymphoma?

Granulomatous slack skin mycosis fungoides developing simultaneously with sarcoid‐like lesions in a patient with repeated anabolic injections in the past?

Sarcoidosis: Various Presentations, Coexisting Diseases and Malignancies

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