Sarcoidosis Versus Lymphoma?

Lago, Lissandra Dal; Sarrand, Julie; Woff, Erwin; Awada, Ahmad; Vouche, Michaël; Pepersack, Thierry

doi:10.12890/2021_002250

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…23,24 Corresponding clinical and imaging features and pathological outcomes suggest noncaseating granuloma, while other similar diseases are excluded. 25 Infection and Drug Resistance 2023:16…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium porcinum Infection of Hilar and Mediastinal Lymph Nodes: A Case Report and Literature Review

Wei,

Luo,

Chen

et al. 2023

IDR

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In the available reports on clinical medicine, the infection sites of Mycobacterium porcinum include wounds, bone marrow, respiratory tract, and catheters. A 61-year-old woman was admitted to our hospital; her hilar and mediastinal lymph nodes were found to be enlarged during health examination, but there was no specific discomfort. Initially, she had undergone a mediastinal lymph node biopsy and pathology, but the diagnosis was not confirmed. However, 16S rRNA gene sequencing revealed M. porcinum infection of hilar and mediastinal lymph nodes. Subsequently, she was treated with clarithromycin, amikacin, imipenem, and tigecycline. After 2 months, chest computed tomography showed a significant reduction in lymph nodes. M. porcinum infection was considered to be the cause of disease.

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Section: Discussionmentioning

confidence: 99%

Mycobacterium porcinum Infection of Hilar and Mediastinal Lymph Nodes: A Case Report and Literature Review

Wei,

Luo,

Chen

et al. 2023

IDR

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“…Cases of SLRs are extensively described in literature in non-Hodgkin lymphoma at diagnosis, after systemic treatment or stem cell transplantation, and in solid cancers after treatment with immune checkpoint inhibitors. 12 , 14 , 15 , 16 However, the exact pathophysiological mechanism is still unknown. The association of an interferon-γ–producing T helper 17 (Th17) T-cell subset with the occurrence of sarcoidosis after immune checkpoint inhibitors led to the hypothesis that (re)activation of CD4 Th1 cells could lead to macrophage activation, aggregation, and, thereby, induction of granuloma formation.…”

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confidence: 99%

Inflammatory reactions mimic residual or recurrent lymphoma on [18F]FDG-PET/CT after CD19-directed CAR T-cell therapy

de Boer,

Pennings,

Kleinjan

et al. 2023

Blood Advances

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Isolated ocular sarcoidosis

Safonova,

Zaitseva

2024

Medicinskij sovet

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A rare clinical case of a patient with isolated sarcoidosis of the eyes is presented. Sarcoidosis is a polyethological disease, the morphological feature of which is the formation of epithelioid cell granulomas in various organs and tissues, which is accompanied by a violation of their structure and function. Both congenital and adaptive immune systems are involved in the pathogenesis of sarcoidosis, with damage to lymph nodes, lungs, skin, organ of vision, etc. Risk factors for the development of sarcoidosis have not been definitively established. Environmental factors and genetic predisposition play a crucial role in the development of the disease. The above clinical observation demonstrates the polymorphism of the clinical picture of isolated ocular sarcoidosis. In addition to standard ophthalmic examination methods, the genetic method of reverse transcription and quantitative polymerase chain reaction (RT-PCR, English qRT-PCR) was also used to determine the expression profile of signature microRNAs as potential diagnostic markers of sarcoidosis of the organ of vision.An increase in the expression level of hsa-miR-455-3p, hsa-miR-4663, hsamiR68063p, hsa-miR-450b-5p, hsa-miR-6716-3p, hsa-miR-5000-5p, hsa-miR150-5p can be considered as potential diagnostic biomarkers of sarcoid lesion of eye structures. With sarcoidosis, the involvement of the lacrimal gland is possible. In the presented clinical observation, this was indicated by the results of a functional examination, sonographic signs: revealed multiple linear tubular hyperechoic structures and a decrease in blood flow velocity in the ocular and lacrimal arteries, as well as an increase in the expression activity of hsa-miR150-5p (p < 0.05). In order to prevent possible damage to the ocular surface due to the development of lacrimal gland dysfunction, it is advisable to prescribe local tear replacement therapy with hyaluronic acid preparations. Such effective drugs include tear substitutes of the Optinol® line: “Optinol® Express Moisture” and “Optinol® Deep Moisture”.

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Sarcoidosis Versus Lymphoma?

Cited by 3 publications

References 13 publications

Mycobacterium porcinum Infection of Hilar and Mediastinal Lymph Nodes: A Case Report and Literature Review

Mycobacterium porcinum Infection of Hilar and Mediastinal Lymph Nodes: A Case Report and Literature Review

Inflammatory reactions mimic residual or recurrent lymphoma on [18F]FDG-PET/CT after CD19-directed CAR T-cell therapy

Isolated ocular sarcoidosis

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