A mini-review on drug delivery through wafer technology: Formulation and manufacturing of buccal and oral lyophilizates

Costa, Juliana Souza Ribeiro; Cruvinel, Karen de Oliveira; Nascimento, Laura de Oliveira

doi:10.1016/j.jare.2019.04.010

Cited by 47 publications

(21 citation statements)

References 52 publications

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“…Exerting similar properties to that of films, wafers have been also investigated for local delivery to the oral cavity. The advantage of wafers of films is reported to be low residual moisture and increased drug loading [181]. Recently, our group has developed monolayer and bilayered mucoadhesive film and wafer formulations as local drug delivery platforms for treatment of oral infections, using chitosan and hydroxypropyl methylcellulose (HPMC) [182].…”

Section: Films and Wafersmentioning

confidence: 99%

Current status and future of delivery systems for prevention and treatment of infections in the oral cavity

Şenel

Özdoğan²,

Akca

2021

Drug Deliv. and Transl. Res.

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Oral health reflects the general health, and it is fundamental to well-being and quality of life. An infection in the oral cavity can be associated with serious complications in human health. Local therapy of these infections offers many advantages over systemic drug administration, targeting directly to the diseased area while minimizing systemic side effects. Specialized drug delivery systems into the oral cavity have to be designed in such a fashion that they resist to the aqueous environment that is constantly bathed in saliva and subject to mechanical forces. Additionally, a prolonged release of drug should also be provided, which would enhance the efficacy and also decrease the repeated dosing. This review is aimed to summarize the current most relevant findings related to local drug delivery of various drug groups for prevention and treatment of infections (viral, bacterial, fungal) and infection-related manifestations in the oral cavity. Current therapeutic challenges in regard to effective local drug delivery systems will be discussed, and the recent approaches to overcome these obstacles will be reviewed. Finally, future prospects will be overviewed to promote novel strategies that can be implemented in clinical management for prevention and treatment of oral infections.

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Section: Films and Wafersmentioning

confidence: 99%

Current status and future of delivery systems for prevention and treatment of infections in the oral cavity

Şenel

Özdoğan²,

Akca

2021

Drug Deliv. and Transl. Res.

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“…Synthetic polymers, such as thiolated Chitosan that is stated to be up to 10 times additionally bioadhesive than Chitosan but still biodegradable, can be formulated with wafers [35].…”

Section: Thiolated Chitosanmentioning

confidence: 99%

A Review of Diabetic Foot Ulcer Infections and Lyophilized Wafer Formulation

Jani

Puri

Ubana

2021

JPRI

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Diabetic foot difficulties are the most usually occurring problems globally, resulting in economic disasters for the patients, families, and society. In patients with diabetes, the risk of emerging foot ulcers is 25% high. It has also been in the record that one lower limb amputation occurs every 30 seconds in patients with diabetes worldwide. Novel methods of drug delivery and wound dressing have to develop to solve the lower limb amputation crisis. One such novel method is "Lyophilized wafer formulation." It is an upcoming medicated dressing material that can enhance wound healing and the potential to ingest vast quantities of exudates from Chronic wounds. That can have been formulating by lyophilizing hydrogel of absorbent polymers such as Calcium Alginate, Carrageenan, Thiolated Chitosan, and plasticizer to enhance flexibility withstand the day to day mechanical stress, covered with some adhesive and protective backing layer. Unless it passes evaluation tests such as Fourier-transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC), Scanning electron microscopy (SEM), Exudate handling property, Folding endurance, In-vitro, In-vivo drug release profile, and Gamma-irradiation sterilizes wafer formulation, and it should not administrate directly. Lyophilized wafer formulation will be the most acceptable medicated dressing material in the future that will be useful to treat the normal wound. The wound formation because of diabetic foot ulcer (DFU) infections as there will be site-specific delivery of the drug, packed with an advantage to self administer and easy termination of the drug that can achieve just by removing the wafer case of drug toxicity.

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“…Exerting similar properties to that of lms, wafers have been also investigated for local delivery to the oral cavity. The advantage of wafers of lms is reported to be low residual moisture and increased drug loading [177]. Recently our group has developed monolayer and bilayered mucoadhesive lm and wafer formulations as local drug delivery platforms for treatment of oral infections, using chitosan and hydroxypropyl methylcellulose (HPMC) [178].…”

Section: Films and Wafersmentioning

confidence: 99%

Current status and future of delivery systems for prevention and treatment of infections in the oral cavity

Şenel

Özdoğan

2021

Preprint

View full text Add to dashboard Cite

Oral health reflects the general health and it is fundamental to well-being and quality of life. An infection in the oral cavity can be associated with serious complications in human health. Local therapy of these infections offers many advantages over systemic drug administration, targeting directly to the diseased area while minimizing systemic side effects. Specialized drug delivery systems into the oral cavity have to be designed in such a fashion that they resist to the aqueous environment that is constantly bathed in saliva and subject to mechanical forces. Additionally, a prolonged release of drug should also be provided, which would enhance the efficacy and also decrease the repeated dosing. This review is aimed to summarize the current most relevant findings related to local drug delivery of various drug groups for prevention and treatment of infections (viral, bacterial, fungal) and infection related manifestations in the oral cavity. Current therapeutic challenges in regard to effective local drug delivery systems will be discussed and the recent approaches to overcome these obstacles will be reviewed. Finally, future prospects will be overviewed to promote novel strategies that can be implemented in clinical management for prevention and treatment of oral infections.

show abstract

A mini-review on drug delivery through wafer technology: Formulation and manufacturing of buccal and oral lyophilizates

Cited by 47 publications

References 52 publications

Current status and future of delivery systems for prevention and treatment of infections in the oral cavity

Current status and future of delivery systems for prevention and treatment of infections in the oral cavity

A Review of Diabetic Foot Ulcer Infections and Lyophilized Wafer Formulation

Current status and future of delivery systems for prevention and treatment of infections in the oral cavity

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