Alcohol can induce a leaky gut, with translocation of microbial molecules from the gut into the blood circulation. Although the contribution of inflammation to organ‐mediated damage in lupus has been previously demonstrated, the mechanistic roles of alcohol consumption in lupus activation are not known. Herein, we tested the effects of 10‐week lasting alcohol administration on organ damages and immune responses in 8‐week‐old lupus‐prone Fc gamma receptor IIb–deficient (FcγRIIb−/−) mice. Our study endpoints were evaluation of systemic inflammation and assessment of fecal dysbiosis along with endotoxemia. In comparison with alcohol‐administered wild‐type mice, FcγRIIb−/− mice demonstrated more prominent liver damage (enzyme, histological score, apoptosis, malondialdehyde oxidant) and serum interleukin(IL)‐6 levels, despite a similarity in leaky gut (fluorescein isothiocyanate–dextran assay, endotoxemia and gut occludin‐1 immunofluorescence), fecal dysbiosis (microbiome analysis) and endotoxemia. All alcohol‐administered FcγRIIb−/− mice developed lupus‐like characteristics (serum anti‐dsDNA, proteinuria, serum creatinine and kidney injury score) with spleen apoptosis, whereas control FcγRIIb−/− mice showed only a subtle anti‐dsDNA. Both alcohol and lipopolysaccharide (LPS) similarly impaired enterocyte integrity (transepithelial electrical resistance), and only LPS, but not alcohol, upregulated the IL‐8 gene in Caco‐2 cells. In macrophages, alcohol mildly activated supernatant cytokines (tumor necrosis factor‐α and IL‐6), but not M1 polarization–associated genes (IL‐1β and iNOS), whereas LPS prominently induced both parameters (more prominent in FcγRIIb−/− macrophages than wild type). There was no synergy in LPS plus alcohol compared with LPS alone in both enterocytes and macrophages. In conclusion, alcohol might exacerbate lupus‐like activity partly through a profound inflammation from the leaky gut in FcγRIIb−/− mice.