A mild and efficient procedure for α-bromination of ketones using N-bromosuccinimide catalysed by ammonium acetate

Abstract

Cyclic ketones reacted with N-bromosuccinimide (NBS) catalysed by NH(4)OAc in Et(2)O at 25 degrees C to give the corresponding alpha-brominated ketones in good yields, while acyclic ketones were efficiently brominated in CCl(4) at 80 degrees C.

Synthesis of Some Novel 1-(Substituted Phenyl)-2-(4-(Trimethylsilyl)-1H-1,2,3-Triazol-1-YL) Ketones

“…19 Initially, the 2-bromo-1-(substituted phenyl)ketones 1a-k were reacted with sodium azide in an attempt to synthesize the corresponding 2-azido-1-(substituted phenyl)ketones. However, the isolation of the corresponding 2-azido-1-(substituted phenyl)ketones was in poor yields.…”

Synthesis and reactions of 3-acetyl-6-methyl-2-(methylthio)pyridine

“…7 We studied the bromination of ketone 4 under various conditions. Aromatic methyl ketones can be brominated with molecular bromine in organic solvents, 9,10 cupric bromide, 11 ammonium perbromides, 12 N bromosuccin imide, 13 and some other reagents. Bromination of ketone 4 with molecular bromine in acetic acid and CH 2 Cl 2 was ineffective.…”

Nerve agent simulant detection by using chromogenic triaryl methane cation probes

“…The synthesis involved the use of the previously reported 2-[4-bromo-2-(N,Ndimethylamino)phenyl]ethanol. 24,25 200 mg (0.82 mmol) of bromide was dissolved under argon atmosphere in 8 ml of dry THF. The solution was cooled down to -78 ºC, and then 1.23 ml (1.97 mmol) of a 1.6 M butyl lithium solution was added dropwise.…”