A microwave-assisted facile synthesis of novel coumarin derivatives containing cyanopyridine and furan as antimicrobial agents

Desai, N. C.; Satodiya, H. M.; Rajpara, K. M.; Joshi, V. V.; Vaghani, H. V.

doi:10.1016/j.jscs.2013.12.005

Cited by 20 publications

(8 citation statements)

References 15 publications

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“…By microwave-irradiation, synthesis of coumarin derivatives 85a-e containing cyanopyridine nucleus as antimicrobial agents was carried out. High antibacterial activity observed against E. Coli and P. aeruginosa was reported by these compounds comparable to Ampicillin at 50 mg/ml [61] (Scheme 74).…”

Section: Nicotinonitriles As Anti-microbial Agentsmentioning

confidence: 87%

A Review on The Chemistry of Nicotinonitriles and Their applications

Shamroukh

Kotb²,

Anwar³

et al. 2021

Egypt. J. Chem.

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Several studies on nicotinonitrile and their derivatives because of their wide range of therapeutic activities have been reported. Many drugs containing nicotinonitrile derivatives are available in market such as Bosutinib, Milrinone, Neratinib, and Olprinone. This review article highlights the recently synthesized nicotinonitrile possessing important biological, therapeutic, and medicinal properties.

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Section: Nicotinonitriles As Anti-microbial Agentsmentioning

confidence: 87%

A Review on The Chemistry of Nicotinonitriles and Their applications

Shamroukh

Kotb²,

Anwar³

et al. 2021

Egypt. J. Chem.

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“…One of the main aims of green chemistry is the reduction of the use of organic solvents because of the economical and environmental concerns associated with them, and therefore the development of solvent-free synthetic methods is of the utmost importance. Microwave irradiation (MW) has occurred as a powerful technique offering clean, fast, efficient and economical method for the synthesis of organic compounds with high yields when compare to conventional heating methods [1][2][3][4]. The application of MW in organic synthesis has been the focus of considerable attention in recent years and is becoming a popular technology [5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

A Facile and Microwave Assisted Solvent Free Synthesis of Novel Indole Pyrimidine Imide Derivatives

2019

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A series of novel indole derivatives bearing pyrimidine and cyclic imide scaffolds such as phthalic and maleic anhydrides has been designed and synthesized using both conventional and microwave irradiation (MW) methods under solvent free conditions. The title compounds have been developed by the reaction of 2-aminoo-4-hydroxy-6-(5,1-substituted-indol-3-yl) pyrimidine-5-carbonitrile with phthalic and maleic anhydrides individually using MW method. In addition, these target compounds were also synthesised under conventional heating method. A considerable increase in the reaction rate has been observed with better yields (90-92%) within 2-6 min using microwave irradiation in comparison to conventional thermal treatment.

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“…In the recent years, microwave irradiation have proved to be well established and rapidly growing area in synthetic organic chemistry. Many organic reactions proceed much faster and with higher yields under microwave irradiation when compared to conventional heating [1][2][3]. In this sense, the microwave-assisted synthesis has demonstrated to be an extremely powerful tool because several synthetic transformations and bond-forming steps can be carried out in a single pot [4,5].…”

Section: Introductionmentioning

confidence: 99%

Cu-catalyzed Rapid Synthesis of Novel Fluorinated Indole Derivatives Under Microwave Irradiation

Shaikh¹,

Bagwan²,

Hunagund³

et al. 2018

Chemistry Africa

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Fluorinated indoles have received considerable attention because incorporation of fluorine into target molecule can influence reactivity, selectivity and biological activity. Herein, a simple microwave-assisted synthesis of novel fluorinated indole derivatives have been developed by the reaction of 5-fluoroindoline-2,3-dione with various anilines. The reaction could be conducted using readily available substrates within short periods of 9-15 min under microwave irradiation with good to excellent yields of the product (64-92%). This approach exploits the synthetic potential of microwave irradiation and copper dipyridine dichloride (CuPy 2 Cl 2) combination and offers many advantages such as full reaction control, excellent product yields, shorter reaction time, eco-friendly procedure and rapid feedback.

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A microwave-assisted facile synthesis of novel coumarin derivatives containing cyanopyridine and furan as antimicrobial agents

Cited by 20 publications

References 15 publications

A Review on The Chemistry of Nicotinonitriles and Their applications

A Review on The Chemistry of Nicotinonitriles and Their applications

A Facile and Microwave Assisted Solvent Free Synthesis of Novel Indole Pyrimidine Imide Derivatives

Cu-catalyzed Rapid Synthesis of Novel Fluorinated Indole Derivatives Under Microwave Irradiation

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