Cu-catalyzed Rapid Synthesis of Novel Fluorinated Indole Derivatives Under Microwave Irradiation

Abstract

Fluorinated indoles have received considerable attention because incorporation of fluorine into target molecule can influence reactivity, selectivity and biological activity. Herein, a simple microwave-assisted synthesis of novel fluorinated indole derivatives have been developed by the reaction of 5-fluoroindoline-2,3-dione with various anilines. The reaction could be conducted using readily available substrates within short periods of 9-15 min under microwave irradiation with good to excellent yields of the product (64-92%). This approach exploits the synthetic potential of microwave irradiation and copper dipyridine dichloride (CuPy 2 Cl 2) combination and offers many advantages such as full reaction control, excellent product yields, shorter reaction time, eco-friendly procedure and rapid feedback.

A Facile and Microwave Assisted Solvent Free Synthesis of Novel Indole Pyrimidine Imide Derivatives

“…One of the main aims of green chemistry is the reduction of the use of organic solvents because of the economical and environmental concerns associated with them, and therefore the development of solvent-free synthetic methods is of the utmost importance. Microwave irradiation (MW) has occurred as a powerful technique offering clean, fast, efficient and economical method for the synthesis of organic compounds with high yields when compare to conventional heating methods [1][2][3][4]. The application of MW in organic synthesis has been the focus of considerable attention in recent years and is becoming a popular technology [5][6][7][8][9][10][11][12].…”