A micelle-like structure of poloxamer–methotrexate conjugates as nanocarrier for methotrexate delivery

Ren, Jin; Fang, Zhengjie; Li, Yao; Dahmani, Fatima Zohra; Yin, Lifang; Zhou, Jianping; Yao, Jing

doi:10.1016/j.ijpharm.2015.04.014

Cited by 43 publications

(27 citation statements)

References 36 publications

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“…43 Many chemotherapeutic agents for cancer, including methotrexate, cisplatin, paclitaxel, docetaxel and doxorubicin, have successfully been formulated in PMs. A few representative studies describing PMs for drug delivery applications of cancer include poloxamer-based micelles, 47 PEG-PLA micelles, 48 PEGylated polyglutamic acid micelles 49 and PEG-PAA micelles. 45 …”

mentioning

confidence: 99%

Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors

Din

Aman

Ullah³

et al. 2017

IJN

1,050

481

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Nanotechnology has recently gained increased attention for its capability to effectively diagnose and treat various tumors. Nanocarriers have been used to circumvent the problems associated with conventional antitumor drug delivery systems, including their nonspecificity, severe side effects, burst release and damaging the normal cells. Nanocarriers improve the bioavailability and therapeutic efficiency of antitumor drugs, while providing preferential accumulation at the target site. A number of nanocarriers have been developed; however, only a few of them are clinically approved for the delivery of antitumor drugs for their intended actions at the targeted sites. The present review is divided into three main parts: first part presents introduction of various nanocarriers and their relevance in the delivery of anticancer drugs, second part encompasses targeting mechanisms and surface functionalization on nanocarriers and third part covers the description of selected tumors, including breast, lungs, colorectal and pancreatic tumors, and applications of relative nanocarriers in these tumors. This review increases the understanding of tumor treatment with the promising use of nanotechnology.

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mentioning

confidence: 99%

Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors

Din

Aman

Ullah³

et al. 2017

IJN

1,050

481

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“…133 Generally, polymeric micelles are penetrating the tumors via active or passive targeting mechanisms in which the latter enhanced permeability and retention effects produced after intravenous administration of particles, while active targeting depends on the basic receptormediated interaction between the ligand-modified on the surface of micelles and the molecular markers specifically over-expressed in the cancer cells, such as folate receptors, integrins, and epidermal growth factor receptors. 134,135 More examples of herbal loaded NE are presented in Table 1. [136][137][138][139][140] Nanosphere (NS) Nanosphere is a colloidal aqueous solution with amorphous or crystalline nature having a size range between 10 and 200 nm (Figure 8) that composed of a polymeric core encapsulating active ingredients and/or adsorbing them onto the nanoparticles.…”

Section: Micellementioning

confidence: 99%

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

Rahman

Othman

Hammadi

et al. 2020

IJN

128

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Many types of research have distinctly addressed the efficacy of natural plant metabolites used for human consumption both in cell culture and preclinical animal model systems. However, these in vitro and in vivo effects have not been able to be translated for clinical use because of several factors such as inefficient systemic delivery and bioavailability of promising agents that significantly contribute to this disconnection. Over the past decades, extraordinary advances have been made successfully on the development of novel drug delivery systems for encapsulation of plant active metabolites including organic, inorganic and hybrid nanoparticles. The advanced formulas are confirmed to have extraordinary benefits over conventional and previously used systems in the manner of solubility, bioavailability, toxicity, pharmacological activity, stability, distribution, sustained delivery, and both physical and chemical degradation. The current review highlights the development of novel nanocarrier for plant active compounds, their method of preparation, type of active ingredients, and their biomedical applications.

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“…[9][10][11][12][13][14][15] Methotrexate (MTX) is a folate receptor antagonist that was originally developed as a chemotherapeutic agent to treat various kinds of malignancies, including leukemia, breast cancer, lung cancer, head and neck cancer, osteosarcoma, and non-Hodgkin's lymphoma. 16,17 It has also been reported that low doses of MTX are effective to treat some inflammatory and autoimmune conditions such as rheumatoid arthritis and psoriasis. 18 Oral and parenteral administration of MTX is associated with serious side effects, including gastrointestinal and hepatic toxicity.…”

Section: Introductionmentioning

confidence: 99%

Improved skin permeation of methotrexate via nanosized ultradeformable liposomes

Zeb¹,

Qureshi²,

Kim³

et al. 2016

IJN

120

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The aim of this study is to investigate methotrexate-entrapped ultradeformable liposomes (MTX-UDLs) for potential transdermal application. MTX-UDLs were prepared by extrusion method with phosphatidylcholine as a bilayer matrix and sodium cholate or Tween 80 as an edge activator. The physicochemical properties of MTX-UDLs were determined in terms of particle size, polydispersity index, zeta potential, and entrapment efficiency. The deformability of MTX-UDLs was compared with that of methotrexate-entrapped conventional liposomes (MTX-CLs) using a steel pressure filter device. The skin permeation of MTX-UDLs was investigated using Franz diffusion cell, and the skin penetration depth of rhodamine 6G-entrapped UDLs was determined by confocal laser scanning microscopy. MTX-UDLs showed a narrow size distribution, with the particle size of ~100 nm. The deformability of MTX-UDLs was two to five times greater than that of MTX-CLs. The skin permeation of MTX-UDLs was significantly improved compared with MTX-CLs and free MTX solution. The optimized UDLs (phosphatidylcholine: Tween 80 =7:3, w/w) showed a higher fluorescence intensity than conventional liposomes at every increment of skin depth. Thus, the optimized UDLs could be promising nanocarriers for systemic delivery of MTX across skin.

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A micelle-like structure of poloxamer–methotrexate conjugates as nanocarrier for methotrexate delivery

Cited by 43 publications

References 36 publications

Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors

Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

Improved skin permeation of methotrexate via nanosized ultradeformable liposomes

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