A method of online quantitative interpretation of diffuse reflection profiles of biological tissues

Lisenko, S. A.; Kugeiko, M. M.

doi:10.1134/s0030400x13020185

Opt. Spectrosc.

2013

DOI: 10.1134/s0030400x13020185

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A method of online quantitative interpretation of diffuse reflection profiles of biological tissues

S. A. Lisenko

M. M. Kugeiko

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Cited by 7 publications

(17 citation statements)

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“…The tissue concentration of bilirubin can be determined by noninvasive methods by measuring the spectral or the spectral and spatial characteristics of the diffuse refl ection by the tissue [14-16, 21, 22]. The measurements can be made based on both fi ber-optic technology [14][15][16] and contactless measurement systems [21,22]. Analytical solutions of the corresponding forward and inverse problems, proposed in [14,16,21,22], allow us to process the measurement data in real time and with high accuracy.…”

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confidence: 99%

“…Let us consider a model for skin with two homogeneous and planeparallel layers: the epidermis and the dermis [14][15][16]. Obviously in such a medium, the radiation fi eld is horizontally homogeneous, i.e., the radiation density E(z, λ) depends only on the one vertical coordinate z, measured from the surface of the medium.…”

mentioning

confidence: 99%

“…Let the change in the ZZ-bilirubin concentration in the skin tissues, due to its production in blood, during this time period be ΔC ZZ . The value of ΔC ZZ can be determined based on noninvasive measurements of the total bilirubin concentration in the skin of the patient before phototherapy begins [14][15][16]22]. Then the illumination of the skin of the patient during phototherapy should satisfy the obvious condition:…”

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confidence: 99%

“…For specifi ed parameters of the medium modeling skin tissue, the optical characteristics of the medium, taking into account the above comments, are calculated using the formulas [14][15][16]22]:…”

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Method for Estimating Bilirubin Isomerization Efficiency in Phototherapy to Treat Neonatal Jaundice

Lisenko

Kugeiko

2014

J Appl Spectrosc

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We propose a method for quantitative assessment of the effi cacy of phototherapy to treat neonatal jaundice using the diffuse refl ectance spectrum for the newborn's skin, based on the analytical dependence of the measured spectrum on the structural and morphological parameters of the skin, affecting the optical conditions in the medium, and an algorithm for rapid calculation of the bilirubin photoisomerization rate in the skin tissues as a function of the structural and morphological parameters of the skin and the wavelength of the exciting radiation. From the results of a numerical simulation of the process of radiation transport in the skin, we assess the stability of our method to variations in the scattering properties of the skin and the concentrations of its optically active chromophores (melanin, oxyhemoglobin, deoxyhemoglobin). We show that in order to achieve the maximum effi cacy of phototherapy, we should use light from the range 484-496 nm. In this case, the intensity of the exciting radiation should be selected individually for each newborn according to the bilirubin photoisomerization rate characteristic for it.Introduction. Hyperbilirubinemia (jaundice) develops in newborns as a result of accumulation of excess ZZbilirubin molecules, a toxic pigment formed from hemoglobin as a result of breakdown of erythrocytes, in the blood (and consequently in the skin tissues). The most widely used method for treating hyperbilirubinemia is phototherapy. When the skin of a newborn is exposed to optical radiation, isomerization of the ZZ-bilirubin molecules found in the skin occurs, with formation of low-toxicity photoisomers: ZE-bilirubin, EZ-bilirubin (confi gurational photoisomers), and lumirubin (LR, structural photoisomer) [1]. EZ-bilirubin, by absorbing a photon of radiation, then is also transformed to LR. LR molecules are considerably more hydrophilic than ZZ-bilirubin molecules and its confi gurational isomers, and so LR dissolves well in water and is easily excreted from the body. ZZ-bilirubin molecules from the blood replace the isomerized bilirubin in the subcutaneous tissue and also undergo isomerization. Treatment is accompanied by periodic blood draws from the patient, and is continued until the blood bilirubin level is reduced to a value safe for the patient.Currently in medical practice there is no standardized method for phototherapy to treat neonatal jaundice. Phototherapy systems are diverse, as are the radiation sources used in them (fl uorescent lamps, halogen lamps, light-emitting diodes, etc.). In a number of cases, modern phototherapy is characterized by low effi ciency (slow reduction of the blood bilirubin level), and is associated with harmful side effects of overdosing [2]. A large number of theoretical and experimental papers have been published that are devoted to selecting the light source that will provide the highest rate of decrease in the ZZbilirubin content in skin tissue and blood of newborns with the lowest possible exposure dose. The results of most of the studies show th...

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confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Method for Estimating Bilirubin Isomerization Efficiency in Phototherapy to Treat Neonatal Jaundice

Lisenko

Kugeiko

2014

J Appl Spectrosc

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“…Recently we proposed a regression approach to quantitative interpretation of backscatter signals from tissue [13][14][15] which has a number of important advantages. First of all, it does not have any limitations on spectral range, experimental geometry, or optical parameters of the tissue.…”

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confidence: 99%

Determination of Constituent Composition of Hemoglobin and Structural/Morphological Parameters of Skin Based on Approximating Functions for Radiation Fluxes Backscattered from Skin

Lisenko

Kugeiko

2014

J Appl Spectrosc

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We have obtained an analytical expression approximating the dependence of the backscatter signals, detected outside the region where the skin is irradiated, on the optical and structural parameters of the skin. A method is proposed for fast determination of the optical and structural/morphological parameters of skin and also the constituent composition of hemoglobin (including oxyhemoglobin, deoxyhemoglobin, carboxyhemoglobin, methemoglobin, and sulfhemoglobin), based on measurements of the spatially resolved spectral backscatter signals and their analytical dependence on the unknown parameters. Based on numerical modeling results for the backscatter signal, we studied the effectiveness of the proposed method and have shown that it is possible to improve the diagnostic power as a result of simultaneous processing of the spectral and spatial characteristics of backscatter from skin.

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Online determination of biophysical parameters of mucous membranes of a human body

Lisenko¹,

Kugeiko²

2013

Quantum Electron.

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A method of online quantitative interpretation of diffuse reflection profiles of biological tissues

Cited by 7 publications

References 23 publications

Method for Estimating Bilirubin Isomerization Efficiency in Phototherapy to Treat Neonatal Jaundice

Method for Estimating Bilirubin Isomerization Efficiency in Phototherapy to Treat Neonatal Jaundice

Determination of Constituent Composition of Hemoglobin and Structural/Morphological Parameters of Skin Based on Approximating Functions for Radiation Fluxes Backscattered from Skin

Online determination of biophysical parameters of mucous membranes of a human body

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