Determination of Constituent Composition of Hemoglobin and Structural/Morphological Parameters of Skin Based on Approximating Functions for Radiation Fluxes Backscattered from Skin

Abstract

We have obtained an analytical expression approximating the dependence of the backscatter signals, detected outside the region where the skin is irradiated, on the optical and structural parameters of the skin. A method is proposed for fast determination of the optical and structural/morphological parameters of skin and also the constituent composition of hemoglobin (including oxyhemoglobin, deoxyhemoglobin, carboxyhemoglobin, methemoglobin, and sulfhemoglobin), based on measurements of the spatially resolved spectral backscatter signals and their analytical dependence on the unknown parameters. Based on numerical modeling results for the backscatter signal, we studied the effectiveness of the proposed method and have shown that it is possible to improve the diagnostic power as a result of simultaneous processing of the spectral and spatial characteristics of backscatter from skin.

Monte Carlo simulation of the effect of melanin concentration on light-tissue interactions in transmittance and reflectance finger photoplethysmography

“…1) implemented in MATLAB, providing a set of conditions to govern the movement of photons at 660 nm and 940 nm through the finger model as they undergo absorption, scattering, reflection, and transmission. Hence, all the optical properties of the layers and constituents of a human finger were acquired from the literature at these two wavelengths [31][32][33][34][35][36][37] (Table 2). The position of the photons were Figure 1.…”

“…Optical properties of all the tissue components of a human finger at 660 nm and 940 nm, as obtained from the literature [31][32][33][34][35][36][37] .…”