BRUNTON and ISRAELS [1930] noted that a rise of alveolar CO2 after mixed meals, first described by Dodds [1921], occurs more regularly than any such rise of alveolar CO2 after stimulation of gastric secretion by such agents as histamine or caffeine. They described experiments with these bases in which the (minimum) volumes of gastric secretion and the associated changes in the secretion of acid by the kidney were measured but in which no rise of alveolar C02 occurred. Dodds's subjects had usually taken mixed meals [Dodds, 1921;Dodds and Bennett, 1921;Bennett and Dodds, 1921;Dodds, 1923]. Moreover, in the various contributions to the solution of the question whether there is an " alkaline tide" after meals, too little attention has been paid to the composition of the meals, and it seemed possible that the conflicting results reported might be due to differences in the nature of the food taken by the subjects of the experiments. In any case it was desirable that information should be obtained as to the effects which specified articles of diet might have. Experiments are reported here as to the effect of various articles of diet upon the acidity of the urine and as controls for comparison other experiments in which nothing was taken, or merely water.Various methods have been used for studying the effect of meals on the acidity of the urine. The method adopted here involves a principle recognized by Do d ds, namely that the amount of urine passed in unit time should be combined with the titration equivalent of unit volume of the urine, and that the amount of titratable acid in the urine excreted in unit time so obtained is more significant than the amount in unit volume of urine. In the experiments to be described this principle is adhered to and the results are presented as curves showing the amount of titratable acid in the urine passed per minute. This may, for convenience, be referred to as "acid per minute," and the more usually estimated PH. LXXVIII. 5