A method for the determination of l-naphthol in urine

Shafik, M. T.; Sullivan, Hazel C.; Enos, Henry F.

doi:10.1007/bf01559071

Cited by 28 publications

(10 citation statements)

References 5 publications

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“…This decrease could possibly be a result of continued elimination from a previous exposure. After carbaryl application, the applicator's urinary 1-naphthol concentration rose sharply and peaked at 22,000 p'g/l (9,300 pg/g creatinine), a level comparable to other reported occupational carbaryl exposures (12,13). As the applicator's serum 1-naphthol levels dramatically decreased in the days following application, the urinary 1-naphthol level remained much higher than that of preexposure samples as 1-naphthol was being eliminated from the body.…”

Section: Resultssupporting

confidence: 66%

Correlation of Environmental Carbaryl Measurements with Serum and Urinary 1-Naphthol Measurements in a Farmer Applicator and His Family

Shealy¹,

Barr²,

Ashley³

et al. 1997

Environmental Health Perspectives

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In exposure or risk assessments, both environmental and biological measurements are often used. Environmental measurements are an excellent means for evaluating regulatory compliance, but the models used to esimae body b n from ee arec Unless .ll possible routes of exposure (i.e., inhalation, derma abso n, inetion) are evaluated, eosure to a toxicant can be underestimated. To crcumvent this problem, measurements of the internal dose of a toxicant in blood, serum, urine, or tissues can be used sinlaly or in combination with environmentl data for exposure assessment. In three separate laboratories, carbaryl or its primary metabolite, l-naphthol, was measured i personal air, dermal samples, blood serum, and urine from farmer applicators and their fimilies. The u ess of both environmenl ad biological data has been demonstrated. For the farmer applicator, he environmental levels of carbaryl would have been sufficient to determine that. an exposure had occurred. However, biological measurements were necessary to determine the absorbed dose of eacmember of the applicator's family. In addition, a correlation between serum and urinary 1--naphthol measurements has been shown; therefore, either matrix can be used to accurately evaluate occupational carbaryl exposure.

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Section: Resultssupporting

confidence: 66%

Correlation of Environmental Carbaryl Measurements with Serum and Urinary 1-Naphthol Measurements in a Farmer Applicator and His Family

Shealy¹,

Barr²,

Ashley³

et al. 1997

Environmental Health Perspectives

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show abstract

“…Because naphthalene can be absorbed through the skin, it is widely accepted that personal air monitoring alone cannot provide sufficient protection of employees from health risks that result from occupational naphthalene exposure. 1-Hydroxynaphthalene (1-naphthol) and 2-hydroxynaphthalene (2-naphthol) have often been used as urinary biomarkers of occupational exposure to naphthalene in the past (Bieniek 1994(Bieniek , 1997(Bieniek , 1998Hansen et al 1994a, b;Heikkila¨et al 1995Heikkila¨et al , 1997Kim et al 1999Kim et al , 2001Nan et al 2001;Preuss et al 2003c;Serdar et al 2003;Shafik et al 1971). The present knowledge, in terms of occurrence, production, use, environmental and occupational exposure of humans, metabolism and hypothesised mechanisms of carcinogenesis of naphthalene, were recently reviewed by Preuss et al (2003a).…”

Section: Introductionmentioning

confidence: 93%

Current external and internal exposure to naphthalene of workers occupationally exposed to polycyclic aromatic hydrocarbons in different industries

Preuss

Drexler

Böttcher

et al. 2005

Int Arch Occup Environ Health

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Actual conditions of occupational hygiene at the workplaces investigated in this comprehensive study are better than those that current limit values of 50,000 microg/m3 (TLV, TRK) seem to induce. It has become obvious that tobacco smoking is a crucial confounding factor in biological monitoring of naphthalene-exposed humans, making interpretation of occupationally increased naphthol excretions very difficult at low exposure levels.

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“…Numerous analytical methodologies for biological monitoring of urinary phenolic chemicals in occupationally exposed populations have been published [1][2][3][4][5]. The limits of detection (LODs) of these methods range from 1 g/L to 60 g/L.…”

Section: Introductionmentioning

confidence: 99%

Quantification of phenolic metabolites of environmental chemicals in human urine using gas chromatography–tandem mass spectrometry and isotope dilution quantification

Bravo

Caltabiano

Fernández

et al. 2005

Journal of Chromatography B

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A method for the determination of l-naphthol in urine

Cited by 28 publications

References 5 publications

Correlation of Environmental Carbaryl Measurements with Serum and Urinary 1-Naphthol Measurements in a Farmer Applicator and His Family

Correlation of Environmental Carbaryl Measurements with Serum and Urinary 1-Naphthol Measurements in a Farmer Applicator and His Family

Current external and internal exposure to naphthalene of workers occupationally exposed to polycyclic aromatic hydrocarbons in different industries

Quantification of phenolic metabolites of environmental chemicals in human urine using gas chromatography–tandem mass spectrometry and isotope dilution quantification

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