A method for the assessment of the coefficient of friction of articular cartilage and a replacement biomaterial

Mahmood, Humaira; Eckold, David G.; Stead, Iestyn; Shepherd, Duncan E.T.; Espino, Daniel M.; Dearn, Karl D.

doi:10.1016/j.jmbbm.2019.103580

Cited by 14 publications

(12 citation statements)

References 48 publications

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“…According to the Figure 2(d,e), the breaking tensile strength decreased after immersed in PBS for 5 days and then leveled off after 5 days. For cartilage repair/regeneration, the friction coefficient is also important 40–42 . Figure 2(f) showed the curve of friction coefficient of the γ‐PGA and La 3+ ‐γ‐PGA hydrogels.…”

Section: Resultsmentioning

confidence: 99%

La³⁺ modified poly(γ‐glutamic acid) hydrogels with high strength and anti‐swelling property for cartilage regeneration

Zhang

Chen

et al. 2021

J of Applied Polymer Sci

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The applications of synthetic hydrogels in cartilage regeneration are usually limited by their weak mechanical properties, uncontrolled swelling/degradation, and insufficient osteogenic activity. Developing tough hydrogels have been attracting great attention in biomedical engineering. In this study, a high strength and tough poly(γ‐glutamic acid) (γ‐PGA) hydrogels with excellent anti‐swelling property were developed by immersing as‐prepared γ‐PGA hydrogels in LaCl3 aqueous solution. Results revealed that the concentration of LaCl3 aqueous solution has great influence on the mechanical properties of γ‐PGA hydrogels. The tensile strength of γ‐PGA hydrogels improved from 0.12 ± 0.02 MPa to 14.65 ± 0.48 MPa when LaCl3 concentration was 0.15 M. Moreover, the swelling ratio decreased from 1035.75 ± 33.16% to 18.21 ± 3.08%. The morphology and microstructure of La3+ reinforced γ‐PGA hydrogels were characterized by SEM/EDS, FT‐IR and XPS. Furthermore, in vitro cytocompatibility of La3+ reinforced γ‐PGA hydrogels was evaluated via MC3T3‐E1 cells. Finally, this study provides a facile and effective strategy for modifying the mechanical and swelling properties of γ‐PGA‐based hydrogels, which offers great potential applications in cartilage repair and regeneration.

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Section: Resultsmentioning

confidence: 99%

La³⁺ modified poly(γ‐glutamic acid) hydrogels with high strength and anti‐swelling property for cartilage regeneration

Zhang

Chen

et al. 2021

J of Applied Polymer Sci

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“…6,48 Tests were conducted at 1 Hz with a stroke length of 10 mm, giving an average sliding speed of 20 mm/s which covers that used in the tribology experiments of hydrogels synthesized for cartilage repair. 55–57 The friction experiments were carried out for 1 h at loads of 2.5, 5 and 10 N, which resulted in average contact pressures of 0.01–0.07 MPa 58 according to Hertzian contact calculation. The range of normal load was selected such that to avoid possible ploughing effect which may be caused by the shear stress exerted on the hydrogels.…”

Section: Methodsmentioning

confidence: 99%

An investigation on tribological behavior of methacrylated κ-carrageenan and gellan gum hydrogels as a candidate for chondral repair

Kanca

Özkahraman

2022

J Biomater Appl

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Natural polysaccharides have recently attracted attention as structural biomaterials to replace focal chondral defects. In the present study, in-vitro tribological performance of methacrylated κ-carrageenan and gellan gum hydrogels (KA-MA and GG-MA) was evaluated under physiological conditions. Coefficient of friction (COF) was continuously recorded over testing whilst worn area was measured post-testing. The findings help improve our understanding of KA-MA-H and GG-MA-H tribological performance under various physiological conditions. The friction and wear performance of the hydrogels improved in bovine calf serum lubricant at lower applied loads. Adhesion was the dominant wear mechanism detected by SEM. Among the proposed hydrogels GG-MA-H found robust mechanical properties, increased wear resistance and considerably low COF, which may suggest its potential usage as a cartilage substitute.

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“…Different friction pairs and lubricants also influence the test results. [29] Given the change of experiment conditions, the COF of pure PVA hydro-gel is measured within the range of 0.0276 to 0.147. [26,30] Previous studies finds the addition of BC enhances the mechanical strength rather than lubrication property, [31,32] while the addition of glycerol plays an opposite role.…”

Section: Tribological Propertymentioning

confidence: 99%

Cationic Modified PVA Hydrogels Provide Low Friction and Excellent Mechanical Properties for Potential Cartilage and Orthopedic Applications

Chen

Song

Wang

et al. 2022

Macromolecular Bioscience

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Poly(vinyl alcohol) (PVA) hydrogel is a promising candidate for articular cartilage repair yet restrained by its mechanical strength and tribological property. Current work reports a newly designed PVA‐based hydrogel modified by glycerol (g), bacterial cellulose (BC), and a cationic polymer poly (diallyl dimethylammonium chloride) (PDMDAAC), which is a novel cationic strengthening choice. The resultant PVA‐g‐BC‐PDMDAAC hydrogel proves the effectiveness of this modification scheme, with a confined compressive modulus of 19.56 MPa and a friction coefficient of 0.057 at a joint‐equivalent load and low sliding speed. The water content, swelling property, and creep behavior of this hydrogel are also within a cartilage‐mimetic range. The properties of PVA‐based hydrogels before PDMDAAC addition are likewise studied as a cross‐reference. Besides, PDMDAAC‐modified PVA hydrogel realizes ideal mechanical and lubrication properties with a relatively low PVA concentration (10 wt.%) and facile fabrication process, which lays a foundation for mass production and marketization in the future.

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A method for the assessment of the coefficient of friction of articular cartilage and a replacement biomaterial

Cited by 14 publications

References 48 publications

La³⁺ modified poly(γ‐glutamic acid) hydrogels with high strength and anti‐swelling property for cartilage regeneration

La³⁺ modified poly(γ‐glutamic acid) hydrogels with high strength and anti‐swelling property for cartilage regeneration

An investigation on tribological behavior of methacrylated κ-carrageenan and gellan gum hydrogels as a candidate for chondral repair

Cationic Modified PVA Hydrogels Provide Low Friction and Excellent Mechanical Properties for Potential Cartilage and Orthopedic Applications

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A method for the assessment of the coefficient of friction of articular cartilage and a replacement biomaterial

Cited by 14 publications

References 48 publications

La3+ modified poly(γ‐glutamic acid) hydrogels with high strength and anti‐swelling property for cartilage regeneration

La3+ modified poly(γ‐glutamic acid) hydrogels with high strength and anti‐swelling property for cartilage regeneration

An investigation on tribological behavior of methacrylated κ-carrageenan and gellan gum hydrogels as a candidate for chondral repair

Cationic Modified PVA Hydrogels Provide Low Friction and Excellent Mechanical Properties for Potential Cartilage and Orthopedic Applications

Contact Info

Product

Resources

About

La³⁺ modified poly(γ‐glutamic acid) hydrogels with high strength and anti‐swelling property for cartilage regeneration

La³⁺ modified poly(γ‐glutamic acid) hydrogels with high strength and anti‐swelling property for cartilage regeneration