An investigation on tribological behavior of methacrylated κ-carrageenan and gellan gum hydrogels as a candidate for chondral repair

Abstract

Natural polysaccharides have recently attracted attention as structural biomaterials to replace focal chondral defects. In the present study, in-vitro tribological performance of methacrylated κ-carrageenan and gellan gum hydrogels (KA-MA and GG-MA) was evaluated under physiological conditions. Coefficient of friction (COF) was continuously recorded over testing whilst worn area was measured post-testing. The findings help improve our understanding of KA-MA-H and GG-MA-H tribological performance under various physiological conditions. The friction and wear performance of the hydrogels improved in bovine calf serum lubricant at lower applied loads. Adhesion was the dominant wear mechanism detected by SEM. Among the proposed hydrogels GG-MA-H found robust mechanical properties, increased wear resistance and considerably low COF, which may suggest its potential usage as a cartilage substitute.

Chemically modified seaweed polysaccharides: Improved functional and biological properties and prospective in food applications

“…Benzoylation of κ-CG with benzoyl chloride was successfully performed in pyridine at 60 • C, and the DS reached up to 0.27 (Shrgawi et al, 2023). Typical preparation of methacrylated κ-CG was performed by the reaction with methacrylic anhydride in aqueous medium (pH 8) at 50 • C for 4 h (Kanca & Ozkahraman, 2023).…”

Visible Light-Mediated Cross-Linking of Injectable Gellan Gum Hydrogels Embedding Human Chondrocytes

“…Recently, GGMA was adjuvated with Manuka honey to make it printable and chondrogenic (Scalzone et al, 2022) or with κ-carrageenan to serve as a cartilage substitute (Kanca & Özkahraman, 2023). Another recent study exploited a blend with hyaluronic acid for image-guided interventions (Vieira et al, 2020).…”