2005
DOI: 10.1088/1741-2560/2/1/014
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A method and technical equipment for an acute human trial to evaluate retinal implant technology

Abstract: This paper reports on methods and technical equipment to investigate the epiretinal stimulation of the retina in blind human subjects in acute trials. Current is applied to the retina through a thin, flexible microcontact film (microelectrode array) with electrode diameters ranging from 50 to 360 microm. The film is mounted in a custom-designed surgical tool that is hand-held by the surgeon during stimulation. The eventual goal of the work is the development of a chronically implantable retinal prosthesis to r… Show more

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Cited by 70 publications
(38 citation statements)
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“…Perception of simple visual patterns or phosphenes have been reported from clinical trials of human blind patients (Veraart et al, 1998;Humayun et al, 1999;Humayun et al, 2003;Rizzo et al, 2003;Hornig et al, 2005). Based on an in-vitro model of retinal implant that consists of retinal patches mounted on a planar multielectrode array (MEA), several studies on the properties of electrically-evoked firing of retinal ganglion cells (RGCs) have increased the basic knowledge required to determine effective methods of visual stimulation (Stett et al, 2000;Jensen and Rizzo, 2007;Ryu et al, 2009b).…”
Section: Introductionmentioning
confidence: 99%
“…Perception of simple visual patterns or phosphenes have been reported from clinical trials of human blind patients (Veraart et al, 1998;Humayun et al, 1999;Humayun et al, 2003;Rizzo et al, 2003;Hornig et al, 2005). Based on an in-vitro model of retinal implant that consists of retinal patches mounted on a planar multielectrode array (MEA), several studies on the properties of electrically-evoked firing of retinal ganglion cells (RGCs) have increased the basic knowledge required to determine effective methods of visual stimulation (Stett et al, 2000;Jensen and Rizzo, 2007;Ryu et al, 2009b).…”
Section: Introductionmentioning
confidence: 99%
“…Based on this principle, a retinal prosthesis device stimulates retinal cells with a patterned electrical signal so that a blind patient may sense a patterned phosphene, or something like an image. According to the site at which the retinal stimulator is placed, the retinal prosthesis device is classified into three categories: epi-retinal stimulation [18][19][20][21], sub-retinal stimulation [22][23][24][25], and suprachoroidal transretinal stimulation (STS) [25,26], which has recently been developed. The stimulation site may be located not only in retinal cells, but also in the pathways to the brain, such as the optic nerves [27], which are the transmission lines of visual information, and, of course, in the visual cortex [28], which is the terminal of the visual information.…”
Section: Principle Of Retinal Prosthesis and Types Of Stimulation Sitesmentioning
confidence: 99%
“…As mentioned previously, this method is classified into three types according to the stimulator implantation site: epi-retinal stimulation [18][19][20][21], sub-retinal stimulation [22][23][24], and STS [25,26]. Figure 6 illustrates these three types of retinal implantation.…”
Section: Intraocular Retinal Prosthesismentioning
confidence: 99%
“…The implant system uses this layer as the basis for conducting nerve signals to the brain's visual areas. 1 The system consists of three main components: the retinal stimulator, which is implanted in the eye; the visual interface, worn as glasses; and the rechargeable pocket processor worn around the waist. Figure 2 shows the retinal stimulator.…”
Section: Retinal Implantmentioning
confidence: 99%