A meta-analysis of eNOS and ACE gene polymorphisms and risk of pre-eclampsia in women

Shaik, Abjal Pasha; Sultana, A; Bammidi, Vamsee K; Sampathirao, K; Jamil, Kurnia Fitri

doi:10.3109/01443615.2011.598971

Cited by 36 publications

(25 citation statements)

References 39 publications

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“…6,7 There are controversial reports from different populations related to the role of ACE I/D polymorphism in the pathogenesis of preeclampsia. 1,3,[8][9][10][11][12][13][14][15][16][17] Also, in a few studies the association of AT1R A1166C polymorphism with preeclampsia has been examined. [8][9][10]17 A positive relationship between the degree of oxidative stress and the clinical severity of preeclampsia has been reported, suggesting that the toxic effects of lipoperoxide lead to hypertension, endothelial damage and leukocyte activation.…”

Section: Introductionmentioning

confidence: 99%

Preeclampsia and angiotensin converting enzyme (ACE) I/D and angiotensin II type-1 receptor (AT1R) A1166C polymorphisms: association with ACE I/D polymorphism

Rahimi

Mozafari

et al. 2012

J Renin Angiotensin Aldosterone Syst

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Background: The aim of the present study was to investigate the association between angiotensin converting enzyme (ACE) insertion/deletion (I/D) and angiotensin II type-1 receptor (AT1R) A1166C polymorphisms with the risk of preeclampsia and lipid peroxidation in preeclamptic women from Western Iran. Methods: One hundred and ninety-eight preeclamptic women (128 women with mild and 70 with severe forms) and 100 age-and parity-matched controls were enrolled in this case-control study. Results:The presence of D allele of ACE was associated with a 1.8-fold increased risk of preeclampsia (p=0.002) in total preeclamptic patients. The frequency of AT1R AC+CC genotypes was higher in mild preeclamptic women (32%) compared to controls (27.2%) (p>0.05). In mild preeclamptic women with ID genotype, the level of total antioxidant capacity (TAC) was significantly decreased compared to those with II genotype. Also, there was a trend toward increasing malondialdehyde (MDA) and decreasing TAC levels in mild and severe preeclamptic women with AT1R AA through CC genotypes. Conclusions: Our study indicates that lipid peroxidation and oxidative stress are involved in the development of preeclampsia that might be influenced by polymorphism in the renin-angiotensin-aldosterone system genes.

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Section: Introductionmentioning

confidence: 99%

Preeclampsia and angiotensin converting enzyme (ACE) I/D and angiotensin II type-1 receptor (AT1R) A1166C polymorphisms: association with ACE I/D polymorphism

Rahimi

Mozafari

et al. 2012

J Renin Angiotensin Aldosterone Syst

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“…[12,14] Besides, the studies conducted in the populations of India, China, and Colombia, revealed no significant effect of I/D ACE on the development of preeclampsia. [11,16,19] The observed inconsistency in the above results can be explained by interpopulation and interethnic differences in the distribution of the I/D polymorphism: allele D is predominant in Caucasians from Europe, Australia, and the USA, whereas allele I is more prevalent among Chinese and Indians. [24][25][26][27] …”

Section: Discussionmentioning

confidence: 82%

“…[8][9][10] The available data on the relationship between the polymorphism of ACE gene and the risk of preeclampsia development are contradictory. [11][12][13][14][15][16][17][18][19][20] In this regard, further research is needed to study the role of I/D ACE locus in the development of this complication of pregnancy.…”

Section: Original Articlementioning

confidence: 99%

Untitled

Reshetnikov

2017

AJP

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Objectives: The associations of the insertion-deletion angiotensin-converting enzyme (I/D ACE) genetic polymorphism with the risk of preeclampsia development were studied. Materials and Methods: The study group included 350 women: 100 women with a physiological pregnancy and 250 pregnant women with preeclampsia. All women underwent the typing of I/D polymorphism of the ACE gene. Results: The pregnant women with the preeclampsia of the 2 nd degree of severity showed the lowest concentration of genotype II ACE (11.00%) as compared with pregnant women without preeclampsia (25.00%; odds ratio [OR] = 0.37; P = 0.017; P cor = 0.051). With the preeclampsia of the 3 rd degree of severity, the minimum frequency of the genotype II ACE (7.27%) and the maximum frequency of the allele D ACE (62.73%) are recorded among pregnant women as compared with the pregnant women without preeclampsia (25.00%; OR = 0.24; P = 0.01; P cor = 0.03 and 49.50%, OR = 1.72, P = 0.03, respectively). Conclusions: Thus, the D ACE allele is associated with the risk of preeclampsia development of the 3 rd degree of severity, and the ACE genotype II is a protective factor of preeclampsia development of the 2 nd and the 3 rd degree of severity.

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“…Su et al 25 performed a metaanalysis to investigate the association of eNOS Glu298Asp gene polymorphism with recurrent pregnancy loss (RPL), and reported that eNOS Glu298Asp gene polymorphism was significantly associated with RPL. Shaik et al 26 reported that eNOS Glu298Asp gene polymorphism was not associated with the risk of pre-eclampsia in women by meta-analysis method. In our meta-analysis, we explore the relationship between eNOS Glu298Asp gene polymorphism and ESRD risk.…”

Section: Discussionmentioning

confidence: 99%

Association of Endothelial Nitric Oxide Synthase Glu298Asp Gene Polymorphism with the Risk of End-Stage Renal Disease

Zhou

Yin

2013

Renal Failure

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The association between endothelial nitric oxide synthase (eNOS) Glu298Asp gene polymorphism and end-stage renal disease (ESRD) risk is still controversial. A meta-analysis was performed to evaluate the association between eNOS Glu298Asp gene polymorphism and ESRD susceptibility. A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic database. Six articles were identified for the analysis of association between eNOS Glu298Asp gene polymorphism and ESRD risk. T allele was associated with ESRD susceptibility in overall populations and in Asians (overall populations: p ¼ 0.01, Asian: p < 0.00001). Furthermore, GG genotype might play a protective role against ESRD onset for overall populations, Asians, and Africans. However, a link between eNOS Glu298Asp gene polymorphism and ESRD risk was not found in Caucasians and Brazil population. In conclusion, T allele might become a significant genetic molecular marker for the onset of ESRD in overall populations, and in Asians. However, more studies should be performed in the future.

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A meta-analysis of eNOS and ACE gene polymorphisms and risk of pre-eclampsia in women

Cited by 36 publications

References 39 publications

Preeclampsia and angiotensin converting enzyme (ACE) I/D and angiotensin II type-1 receptor (AT1R) A1166C polymorphisms: association with ACE I/D polymorphism

Preeclampsia and angiotensin converting enzyme (ACE) I/D and angiotensin II type-1 receptor (AT1R) A1166C polymorphisms: association with ACE I/D polymorphism

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Association of Endothelial Nitric Oxide Synthase Glu298Asp Gene Polymorphism with the Risk of End-Stage Renal Disease

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