Association of Endothelial Nitric Oxide Synthase Glu298Asp Gene Polymorphism with the Risk of End-Stage Renal Disease

Abstract

The association between endothelial nitric oxide synthase (eNOS) Glu298Asp gene polymorphism and end-stage renal disease (ESRD) risk is still controversial. A meta-analysis was performed to evaluate the association between eNOS Glu298Asp gene polymorphism and ESRD susceptibility. A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic database. Six articles were identified for the analysis of association between eNOS Glu298Asp gene polymorphism and ESRD risk. T allele was associated with ESRD susceptibility in overall populations and in Asians (overall populations: p ¼ 0.01, Asian: p < 0.00001). Furthermore, GG genotype might play a protective role against ESRD onset for overall populations, Asians, and Africans. However, a link between eNOS Glu298Asp gene polymorphism and ESRD risk was not found in Caucasians and Brazil population. In conclusion, T allele might become a significant genetic molecular marker for the onset of ESRD in overall populations, and in Asians. However, more studies should be performed in the future.

Methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and diabetic nephropathy susceptibility in patients with type 2 diabetes mellitus

“…The pooled statistics were counted using the fixed effects model, but a random effects model was applied when the p value of the heterogeneity test was less than 0.1. 25,26 Results were expressed with odds ratios (OR) for dichotomous data, and additionally 95% confidence intervals (CI) were calculated. p50.05 was required for the overall OR to be deemed statistically significant.…”

Bcıı—RFLP profiles for serum amiloid A1 and mutatedMEFVgene prevalence in chronic renal failure patients requiring long-term hemodialysis

“…Strong association was reported between complement receptor 1 gene and end-stage renal disease (ESRD). 29 Zhou and Yin 30 have claimed that the eNOS Glu298Asp gene polymorphism is associated with the ESRD risk. Kai et al 31 have claimed that germ-line mutations based on thrombophilic disorders such as diabetic nephropathy, polycystic renal disease, hypertension, and thrombophilia with renal failure are possible mechanisms explaining the implication of the thrombophilic states in kidney allograft thrombosis and renal rejection.…”

Association ofT869, C509T, G915Cgene polymorphism of transforming growth factor-β1 with IgA nephropathy risk

“…There were some interesting studies performed to assess the association of the polymorphism of some genes with the onset of some diseases. Zhou and Yin 6 performed a meta-analysis to evaluate the association between endothelial nitric oxide synthase Glu298Asp gene polymorphism and end-stage renal disease (ESRD) susceptibility, and reported that T allele might become a significant genetic molecular marker for the onset of ESRD in overall populations, and in Asians. Bantis et al 7 evaluated the influence of C-344T polymorphism of aldosterone synthase gene, associated with serum aldosterone levels and the development of arterial hypertension, on IgAN, and indicated that aldosterone synthase gene C-344T polymorphism was a risk factor for accelerated progression in Caucasian patients with IgAN.…”